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Volume 20(11);  2000 Jun

Gene Expression

Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway
Georg Stoecklin, Xiu-Fen Ming, Renate Looser, Christoph Moroni
Mol Cell Biol. 2000 Jun; 20(11): 3753–3763. doi: 10.1128/mcb.20.11.3753-3763.2000
PMCID:
PMC85689
Abstract Article PDF–1.7M
CD8 Coreceptor Extinction in Signaled CD4+CD8+ Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes
Ricardo Cibotti, Avinash Bhandoola, Terry I. Guinter, Susan O. Sharrow, Alfred Singer
Mol Cell Biol. 2000 Jun; 20(11): 3852–3859. doi: 10.1128/mcb.20.11.3852-3859.2000
PMCID:
PMC85715
Abstract Article PDF–753K
Mutational Analysis of Mammalian Translation Initiation Factor 5 (eIF5): Role of Interaction between the β Subunit of eIF2 and eIF5 in eIF5 Function In Vitro and In Vivo
Supratik Das, Umadas Maitra
Mol Cell Biol. 2000 Jun; 20(11): 3942–3950. doi: 10.1128/mcb.20.11.3942-3950.2000
PMCID:
PMC85746
Abstract Article PDF–1.2M
Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation
Edith Gomez, Graham D. Pavitt
Mol Cell Biol. 2000 Jun; 20(11): 3965–3976. doi: 10.1128/mcb.20.11.3965-3976.2000
PMCID:
PMC85753
Abstract Article PDF–2.5M
A 5′ Splice Site-Proximal Enhancer Binds SF1 and Activates Exon Bridging of a Microexon
Troy Carlo, Rebecca Sierra, Susan M. Berget
Mol Cell Biol. 2000 Jun; 20(11): 3988–3995. doi: 10.1128/mcb.20.11.3988-3995.2000
PMCID:
PMC85762
Abstract Article PDF–1.5M
Saccharomyces cerevisiae RAI1 (YGL246c) Is Homologous to Human DOM3Z and Encodes a Protein That Binds the Nuclear Exoribonuclease Rat1p
Yang Xue, Xinxue Bai, Insuk Lee, George Kallstrom, Jennifer Ho, Justin Brown, Audrey Stevens, Arlen W. Johnson
Mol Cell Biol. 2000 Jun; 20(11): 4006–4015. doi: 10.1128/mcb.20.11.4006-4015.2000
PMCID:
PMC85771
Abstract Article PDF–2.4M
Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17
Zhihong Jiang, Jocelyn Cote, Jennifer M. Kwon, Alison M. Goate, Jane Y. Wu
Mol Cell Biol. 2000 Jun; 20(11): 4036–4048. doi: 10.1128/mcb.20.11.4036-4048.2000
Correction in:
Mol Cell Biol. 2000 Jul; 20(14): 5360.
PMCID:
PMC85774
Abstract Article PDF–2.5M
hnRNP C Is Required for Postimplantation Mouse Development but Is Dispensable for Cell Viability
Douglas J. Williamson, Sarbani Banik-Maiti, James DeGregori, H. Earl Ruley
Mol Cell Biol. 2000 Jun; 20(11): 4094–4105. doi: 10.1128/mcb.20.11.4094-4105.2000
PMCID:
PMC85779
Abstract Article PDF–13M

Transcriptional Regulation

Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells
Silvia Misiti, Simona Nanni, Giulia Fontemaggi, Yu-Sheng Cong, Jianping Wen, Hal W. Hirte, Giulia Piaggio, Ada Sacchi, Alfredo Pontecorvi, Silvia Bacchetti, Antonella Farsetti
Mol Cell Biol. 2000 Jun; 20(11): 3764–3771. doi: 10.1128/mcb.20.11.3764-3771.2000
PMCID:
PMC85692
Abstract Article PDF–2.6M
Repression of Ribosome and tRNA Synthesis in Secretion-Defective Cells Is Signaled by a Novel Branch of the Cell Integrity Pathway
Yun Li, Robyn D. Moir, Indra K. Sethy-Coraci, Jonathan R. Warner, Ian M. Willis
Mol Cell Biol. 2000 Jun; 20(11): 3843–3851. doi: 10.1128/mcb.20.11.3843-3851.2000
PMCID:
PMC85713
Abstract Article PDF–1.1M
Molecular Determinants of Differential Ligand Sensitivities of Insect Ecdysteroid Receptors
Sheng-Fu Wang, Stephen Ayer, William A. Segraves, Daryl R. Williams, Alexander S. Raikhel
Mol Cell Biol. 2000 Jun; 20(11): 3870–3879. doi: 10.1128/mcb.20.11.3870-3879.2000
PMCID:
PMC85723
Abstract Article PDF–916K
Multiple Signals Regulate GAL Transcription in Yeast
John R. Rohde, Jennifer Trinh, Ivan Sadowski
Mol Cell Biol. 2000 Jun; 20(11): 3880–3886. doi: 10.1128/mcb.20.11.3880-3886.2000
PMCID:
PMC85726
Abstract Article PDF–1.9M
Phosphorylation of SOX9 by Cyclic AMP-Dependent Protein Kinase A Enhances SOX9's Ability To Transactivate a Col2a1 Chondrocyte-Specific Enhancer
Wendong Huang, Xin Zhou, Véronique Lefebvre, Benoit de Crombrugghe
Mol Cell Biol. 2000 Jun; 20(11): 4149–4158. doi: 10.1128/mcb.20.11.4149-4158.2000
Correction in:
Mol Cell Biol. 2000 Oct; 20(20): 7838.
PMCID:
PMC85784
Abstract Article PDF–1.3M
S-Phase Progression Mediates Activation of a Silenced Gene in Synthetic Nuclei
Alison J. Crowe, Julie L. Piechan, Ling Sang, Michelle C. Barton
Mol Cell Biol. 2000 Jun; 20(11): 4169–4180. doi: 10.1128/mcb.20.11.4169-4180.2000
PMCID:
PMC85786
Abstract Article PDF–5.1M

Cell Growth and Development

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53
Dae-Sik Lim, Hannes Vogel, Dennis M. Willerford, Arthur T. Sands, Kenneth A. Platt, Paul Hasty
Mol Cell Biol. 2000 Jun; 20(11): 3772–3780. doi: 10.1128/mcb.20.11.3772-3780.2000
PMCID:
PMC85695
Abstract Article PDF–1.8M
Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid
Michele Barry, Jeffrey A. Heibein, Michael J. Pinkoski, Siow-Fong Lee, Richard W. Moyer, Douglas R. Green, R. Chris Bleackley
Mol Cell Biol. 2000 Jun; 20(11): 3781–3794. doi: 10.1128/mcb.20.11.3781-3794.2000
PMCID:
PMC85698
Abstract Article PDF–1.0M
Hierarchy of S-Phase-Promoting Factors: Yeast Dbf4-Cdc7 Kinase Requires Prior S-Phase Cyclin-Dependent Kinase Activation
Romain Nougarède, Flavio Della Seta, Patrick Zarzov, Etienne Schwob
Mol Cell Biol. 2000 Jun; 20(11): 3795–3806. doi: 10.1128/mcb.20.11.3795-3806.2000
PMCID:
PMC85702
Abstract Article PDF–2.0M
Three Yeast Proteins Related to the Human Candidate Tumor Suppressor p33ING1 Are Associated with Histone Acetyltransferase Activities
Robbie Loewith, Maria Meijer, Susan P. Lees-Miller, Karl Riabowol, Dallan Young
Mol Cell Biol. 2000 Jun; 20(11): 3807–3816. doi: 10.1128/mcb.20.11.3807-3816.2000
PMCID:
PMC85704
Abstract Article PDF–6.2M
Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors
Alexandre Arcaro, Marketa J. Zvelebil, Christian Wallasch, Axel Ullrich, Michael D. Waterfield, Jan Domin
Mol Cell Biol. 2000 Jun; 20(11): 3817–3830. doi: 10.1128/mcb.20.11.3817-3830.2000
PMCID:
PMC85707
Abstract Article PDF–4.2M
Two Distinct Notch1 Mutant Alleles Are Involved in the Induction of T-Cell Leukemia in c-myc Transgenic Mice
C. D. Hoemann, N. Beaulieu, L. Girard, N. Rebai, P. Jolicoeur
Mol Cell Biol. 2000 Jun; 20(11): 3831–3842. doi: 10.1128/mcb.20.11.3831-3842.2000
PMCID:
PMC85710
Abstract Article PDF–1.5M
Rck2 Kinase Is a Substrate for the Osmotic Stress-Activated Mitogen-Activated Protein Kinase Hog1
Elizabeth Bilsland-Marchesan, Joaquín Ariño, Haruo Saito, Per Sunnerhagen, Francesc Posas
Mol Cell Biol. 2000 Jun; 20(11): 3887–3895. doi: 10.1128/mcb.20.11.3887-3895.2000
PMCID:
PMC85729
Abstract Article PDF–2.5M
The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor
Payal Soni, Montaha Lakkis, Matthew N. Poy, Mats A. Fernström, Sonia M. Najjar
Mol Cell Biol. 2000 Jun; 20(11): 3896–3905. doi: 10.1128/mcb.20.11.3896-3905.2000
PMCID:
PMC85733
Abstract Article PDF–1.6M
Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation
Zhou-shen Zhao, Edward Manser, Louis Lim
Mol Cell Biol. 2000 Jun; 20(11): 3906–3917. doi: 10.1128/mcb.20.11.3906-3917.2000
PMCID:
PMC85736
Abstract Article PDF–1.6M
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
Zhenguo Wu, Pamela J. Woodring, Kunjan S. Bhakta, Kumiko Tamura, Fang Wen, James R. Feramisco, Michael Karin, Jean Y. J. Wang, Pier Lorenzo Puri
Mol Cell Biol. 2000 Jun; 20(11): 3951–3964. doi: 10.1128/mcb.20.11.3951-3964.2000
PMCID:
PMC85749
Abstract Article PDF–1.4M
Cpc2, a Fission Yeast Homologue of Mammalian RACK1 Protein, Interacts with Ran1 (Pat1) Kinase To Regulate Cell Cycle Progression and Meiotic Development
Maureen McLeod, Boris Shor, Anthony Caporaso, Wei Wang, Hua Chen, Lin Hu
Mol Cell Biol. 2000 Jun; 20(11): 4016–4027. doi: 10.1128/mcb.20.11.4016-4027.2000
PMCID:
PMC85772
Abstract Article PDF–3.7M
Septin-Dependent Assembly of a Cell Cycle-Regulatory Module in Saccharomyces cerevisiae
Mark S. Longtine, Chandra L. Theesfeld, John N. McMillan, Elizabeth Weaver, John R. Pringle, Daniel J. Lew
Mol Cell Biol. 2000 Jun; 20(11): 4049–4061. doi: 10.1128/mcb.20.11.4049-4061.2000
PMCID:
PMC85775
Abstract Article PDF–7.8M
The p53 Response to DNA Damage In Vivo Is Independent of DNA-Dependent Protein Kinase
Chamelli Jhappan, Timur M. Yusufzai, Stacie Anderson, Miriam R. Anver, Glenn Merlino
Mol Cell Biol. 2000 Jun; 20(11): 4075–4083. doi: 10.1128/mcb.20.11.4075-4083.2000
PMCID:
PMC85777
Abstract Article PDF–3.9M

DNA Dynamics and Chromosome Structure

DDP1, a Heterochromatin-Associated Multi-KH-Domain Protein of Drosophila melanogaster, Interacts Specifically with Centromeric Satellite DNA Sequences
Alfred Cortés, Fernando Azorín
Mol Cell Biol. 2000 Jun; 20(11): 3860–3869. doi: 10.1128/mcb.20.11.3860-3869.2000
PMCID:
PMC85718
Abstract Article PDF–2.7M
Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff
Dirk Strumberg, André A. Pilon, Melanie Smith, Robert Hickey, Linda Malkas, Yves Pommier
Mol Cell Biol. 2000 Jun; 20(11): 3977–3987. doi: 10.1128/mcb.20.11.3977-3987.2000
PMCID:
PMC85758
Abstract Article PDF–3.6M
Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and Orientation
Dan Gebow, Nathan Miselis, Howard L. Liber
Mol Cell Biol. 2000 Jun; 20(11): 4028–4035. doi: 10.1128/mcb.20.11.4028-4035.2000
PMCID:
PMC85773
Abstract Article PDF–208K
Interference of the Simian Virus 40 Origin of Replication by the Cytomegalovirus Immediate Early Gene Enhancer: Evidence for Competition of Active Regulatory Chromatin Conformation in a Single Domain
Peng-Hui Chen, Wen-Bin Tseng, Yi Chu, Ming-Ta Hsu
Mol Cell Biol. 2000 Jun; 20(11): 4062–4074. doi: 10.1128/mcb.20.11.4062-4074.2000
PMCID:
PMC85776
Abstract Article PDF–913K
Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA
Hiroyuki Niida, Yoichi Shinkai, M. Prakash Hande, Takehisa Matsumoto, Shoko Takehara, Makoto Tachibana, Mitsuo Oshimura, Peter M. Lansdorp, Yasuhiro Furuichi
Mol Cell Biol. 2000 Jun; 20(11): 4115–4127. doi: 10.1128/mcb.20.11.4115-4127.2000
PMCID:
PMC85781
Abstract Article PDF–3.2M
A Novel Chromodomain Protein, Pdd3p, Associates with Internal Eliminated Sequences during Macronuclear Development in Tetrahymena thermophila
Mikhail A. Nikiforov, Martin A. Gorovsky, C. David Allis
Mol Cell Biol. 2000 Jun; 20(11): 4128–4134. doi: 10.1128/mcb.20.11.4128-4134.2000
PMCID:
PMC85782
Abstract Article PDF–1.2M

Cell and Organelle Structure and Assembly

Role of Saccharomyces cerevisiae ISA1 and ISA2 in Iron Homeostasis
Laran T. Jensen, Valeria Cizewski Culotta
Mol Cell Biol. 2000 Jun; 20(11): 3918–3927. doi: 10.1128/mcb.20.11.3918-3927.2000
PMCID:
PMC85738
Abstract Article PDF–5.3M
Prolyl 4-Hydroxylase Is an Essential Procollagen-Modifying Enzyme Required for Exoskeleton Formation and the Maintenance of Body Shape in the Nematode Caenorhabditis elegans
Alan D. Winter, Antony P. Page
Mol Cell Biol. 2000 Jun; 20(11): 4084–4093. doi: 10.1128/mcb.20.11.4084-4093.2000
PMCID:
PMC85778
Abstract Article PDF–1.6M

Nucleocytoplasmic Communication

Neoplastic Transformation by Notch Requires Nuclear Localization
Shawn Jeffries, Anthony J. Capobianco
Mol Cell Biol. 2000 Jun; 20(11): 3928–3941. doi: 10.1128/mcb.20.11.3928-3941.2000
PMCID:
PMC85741
Abstract Article PDF–2.7M
Nuclear Export of Heat Shock and Non-Heat-Shock mRNA Occurs via Similar Pathways
Irina E. Vainberg, Ken Dower, Michael Rosbash
Mol Cell Biol. 2000 Jun; 20(11): 3996–4005. doi: 10.1128/mcb.20.11.3996-4005.2000
PMCID:
PMC85767
Abstract Article PDF–3.6M
Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1
K. Prasanna Kumar, Kevin M. McBride, Brian K. Weaver, Colin Dingwall, Nancy C. Reich
Mol Cell Biol. 2000 Jun; 20(11): 4159–4168. doi: 10.1128/mcb.20.11.4159-4168.2000
PMCID:
PMC85785
Abstract Article PDF–4.3M

Mammalian Genetic Models with Minimal or Complex Phenotypes

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
Steffen Jung, Julio Aliberti, Petra Graemmel, Mary Jean Sunshine, Georg W. Kreutzberg, Alan Sher, Dan R. Littman
Mol Cell Biol. 2000 Jun; 20(11): 4106–4114. doi: 10.1128/mcb.20.11.4106-4114.2000
PMCID:
PMC85780
Abstract Article PDF–9.5M
Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway
Yong Tae Kwon, Seth A. Balogh, Ilia V. Davydov, Anna S. Kashina, Jeong Kyo Yoon, Youming Xie, Arti Gaur, Lynn Hyde, Victor H. Denenberg, Alexander Varshavsky
Mol Cell Biol. 2000 Jun; 20(11): 4135–4148. doi: 10.1128/mcb.20.11.4135-4148.2000
PMCID:
PMC85783
Abstract Article PDF–3.5M
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