Volume 1(2); 2018 Nov 9

Review

Rules of Engagement: GPCRs and G Proteins

Alisa Glukhova, Christopher J. Draper-Joyce, Roger K. Sunahara, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 73–83. Published online 2018 Sep 7. doi: 10.1021/acsptsci.8b00026

PMCID:: PMC7089011

Articles

Aglycone Polyether Nanchangmycin and Its Homologues Exhibit Apoptotic and Antiproliferative Activities against Cancer Stem Cells

Minjian Huang, Bo Liu, Ran Liu, Jian Li, Jilei Chen, Fenglei Jiang, Hong Ding, Zixin Deng, Tiangang Liu

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 84–95. Published online 2018 Oct 12. doi: 10.1021/acsptsci.8b00007

PMCID:: PMC7088892

Abstract Article PDF–5.0M

Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

Karen J. Gregory, Irina Kufareva, Andrew N. Keller, Elham Khajehali, Hee-Chang Mun, Mahvash A. Goolam, Rebecca S. Mason, Ben Capuano, Arthur D. Conigrave, Arthur Christopoulos, Katie Leach

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 96–109. Published online 2018 Sep 12. doi: 10.1021/acsptsci.8b00021

PMCID:: PMC7089027

Abstract Article PDF–3.9M

High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing

Netzahualcóyotl Arroyo-Currás, Gabriel Ortega, David A. Copp, Kyle L. Ploense, Zoe A. Plaxco, Tod E. Kippin, João P. Hespanha, Kevin W. Plaxco

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 110–118. Published online 2018 Oct 5. doi: 10.1021/acsptsci.8b00033

PMCID:: PMC7088981

Abstract Article PDF–1.7M

Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling

Amanda J. Kennedy, Flavio Ballante, Johan R. Johansson, Graeme Milligan, Linda Sundström, Anneli Nordqvist, Jens Carlsson

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 119–133. Published online 2018 Oct 16. doi: 10.1021/acsptsci.8b00019

PMCID:: PMC7088944

Abstract Article PDF–7.2M

Viewpoints

Advances in Orphan Nuclear Receptor Pharmacology: A New Era in Drug Discovery

Ian Mitchelle S. de Vera

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 134–137. Published online 2018 Sep 14. doi: 10.1021/acsptsci.8b00029

PMCID:: PMC7088939

Abstract Article PDF–493K

Novel Genetic Variant of a Class B G Protein-Coupled Receptor Reveals a Role for Adrenomedullin in Human Fertility

Debbie L. Hay

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 138–139. Published online 2018 Sep 21. doi: 10.1021/acsptsci.8b00038

PMCID:: PMC7088882

Article PDF–666K

All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators

Rachel A. Coleman, Darci J. Trader

ACS Pharmacol Transl Sci. 2018 Nov 9; 1(2): 140–142. Published online 2018 Oct 18. doi: 10.1021/acsptsci.8b00042

PMCID:: PMC7088911

Abstract Article PDF–787K

Articles from ACS Pharmacology & Translational Science are provided here courtesy of American Chemical Society