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Volume 61;  2022 Jul

Original Articles

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens
Mol Metab. 2022 Jul; 61: 101479. Published online 2022 Mar 24. doi: 10.1016/j.molmet.2022.101479
PMCID:
PMC9046887
Abstract Article PDF–2.7M
Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
Alison D. McNeilly, Adonis Yianakas, Jennifer G. Gallagher, Jamie Tarlton, Michael LJ. Ashford, Rory J. McCrimmon
Mol Metab. 2022 Jul; 61: 101488. Published online 2022 Apr 22. doi: 10.1016/j.molmet.2022.101488
PMCID:
PMC9065900
Abstract Article PDF–2.4M
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
Shaza Asif, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, Alix Denoncourt, Angela C. Cheung, Michael Downey, Erin E. Mulvihill, Kyoung-Han Kim
Mol Metab. 2022 Jul; 61: 101494. Published online 2022 Apr 12. doi: 10.1016/j.molmet.2022.101494
PMCID:
PMC9039870
Abstract Article PDF–5.9M
Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms
Bilal Singh, Firas Khattab, Patrick Gilon
Mol Metab. 2022 Jul; 61: 101495. Published online 2022 Apr 11. doi: 10.1016/j.molmet.2022.101495
PMCID:
PMC9065434
Abstract Article PDF–5.2M

Brief Communication

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome
Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, Joanne A. Hammill, Ksenia Bezverbnaya, Dongdong Wang, Jaya Gautam, Evangelia E. Tsakiridis, Fiorella Di Pastena, Jamie McNicol, Jianhan Wu, Saad Syed, James S.V. Lally, Amogelang R. Raphenya, Marie-Jose Blouin, Michael Pollak, Andrea Sacconi, Giovanni Blandino, Andrew G. McArthur, Jonathan D. Schertzer, Michael G. Surette, Stephen M. Collins, Jonathan L. Bramson, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Mol Metab. 2022 Jul; 61: 101498. Published online 2022 Apr 20. doi: 10.1016/j.molmet.2022.101498
PMCID:
PMC9096669
Abstract Article PDF–2.1M

Original Articles

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Mol Metab. 2022 Jul; 61: 101499. Published online 2022 Apr 22. doi: 10.1016/j.molmet.2022.101499
PMCID:
PMC9097615
Abstract Article PDF–3.0M
SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway
Bai-Yu Li, Ying-Ying Guo, Gang Xiao, Liang Guo, Qi-Qun Tang
Mol Metab. 2022 Jul; 61: 101500. Published online 2022 Apr 15. doi: 10.1016/j.molmet.2022.101500
PMCID:
PMC9062745
Abstract Article PDF–4.6M

Brief Communication

Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element
Kenneth T. Lewis, Lily R. Oles, Ormond A. MacDougald
Mol Metab. 2022 Jul; 61: 101501. Published online 2022 Apr 19. doi: 10.1016/j.molmet.2022.101501
PMCID:
PMC9170755
Abstract Article PDF–3.9M

Review

Role and mechanism of ferroptosis in neurological diseases
Mengmeng Ou, Ying Jiang, Yingying Ji, Qin Zhou, Zhiqiang Du, Haohao Zhu, Zhenhe Zhou
Mol Metab. 2022 Jul; 61: 101502. Published online 2022 Apr 18. doi: 10.1016/j.molmet.2022.101502
PMCID:
PMC9170779
Abstract Article PDF–1.7M

Original Articles

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Mol Metab. 2022 Jul; 61: 101503. Published online 2022 Apr 19. doi: 10.1016/j.molmet.2022.101503
PMCID:
PMC9170783
Abstract Article PDF–3.7M
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pål O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Mol Metab. 2022 Jul; 61: 101504. Published online 2022 Apr 22. doi: 10.1016/j.molmet.2022.101504
PMCID:
PMC9079800
Abstract Article PDF–4.0M
Neuronal miR-29a protects from obesity in adult mice
Yuan Ma, Nicola Murgia, Yu Liu, Zixuan Li, Chaweewan Sirakawin, Ruslan Konovalov, Nikolai Kovzel, Yang Xu, Xuejia Kang, Anshul Tiwari, Patrick Malonza Mwangi, Donglei Sun, Holger Erfle, Witold Konopka, Qingxuan Lai, Syeda Sadia Najam, Ilya A. Vinnikov
Mol Metab. 2022 Jul; 61: 101507. Published online 2022 Apr 29. doi: 10.1016/j.molmet.2022.101507
PMCID:
PMC9114687
Abstract Article PDF–4.8M

Brief Communication

PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes
Jiefu Wang, Yasuhiro Onogi, Martin Krueger, Josef Oeckl, Ruth Karlina, Inderjeet Singh, Stefanie M. Hauck, Regina Feederle, Yongguo Li, Siegfried Ussar
Mol Metab. 2022 Jul; 61: 101508. Published online 2022 May 2. doi: 10.1016/j.molmet.2022.101508
PMCID:
PMC9114668
Abstract Article PDF–2.5M

Original Articles

Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations
Arthur Gilly, Lucija Klaric, Young-Chan Park, Grace Png, Andrei Barysenka, Joseph A. Marsh, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, James F. Wilson, Eleftheria Zeggini
Mol Metab. 2022 Jul; 61: 101509. Published online 2022 Apr 30. doi: 10.1016/j.molmet.2022.101509
PMCID:
PMC9118462
Abstract Article PDF–1.3M
Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
Ivan Bradić, Katharina B. Kuentzel, Sophie Honeder, Gernot F. Grabner, Nemanja Vujić, Robert Zimmermann, Ruth Birner-Gruenberger, Dagmar Kratky
Mol Metab. 2022 Jul; 61: 101510. Published online 2022 Apr 30. doi: 10.1016/j.molmet.2022.101510
PMCID:
PMC9118473
Abstract Article PDF–2.5M
De novo labeling and trafficking of individual lipid species in live cells
Jun Zhang, Jia Nie, Haoran Sun, Jie Li, John-Paul Andersen, Yuguang Shi
Mol Metab. 2022 Jul; 61: 101511. Published online 2022 May 2. doi: 10.1016/j.molmet.2022.101511
PMCID:
PMC9114690
Abstract Article PDF–7.0M

Brief Communications

Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms
Simon Lecoutre, Fatiha Merabtene, Elie-Julien El Hachem, Camille Gamblin, Christine Rouault, Nataliya Sokolovska, Hedi Soula, Wi S. Lai, Perry J. Blackshear, Karine Clément, Isabelle Dugail
Mol Metab. 2022 Jul; 61: 101512. Published online 2022 May 9. doi: 10.1016/j.molmet.2022.101512
PMCID:
PMC9123279
Abstract Article PDF–2.2M
Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis
Man K.S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Mol Metab. 2022 Jul; 61: 101514. Published online 2022 May 10. doi: 10.1016/j.molmet.2022.101514
PMCID:
PMC9124714
Abstract Article PDF–2.9M
Articles from Molecular Metabolism are provided here courtesy of Elsevier
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