Volume 13(3); 2023

Addiction

Allostatic load in opioid use disorder: a scoping review protocol

Jaimie Qiuyun Fan, Hillary Miller, Amanda Adams, Rebecca Bryan, Matthew Salzman

BMJ Open. 2023; 13(3): e060522. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2021-060522

PMCID:: PMC10030489

Social norms and goal-setting interventions to promote responsible gambling in low-to-moderate online gamblers: protocol for a four-arm randomised controlled feasibility study

Emily Arden-Close, Sarah Thomas, Reece Bush-Evans, Ruijie Wang, Elvira Bolat, Sarah Hodge, Keith Phalp, John McAlaney

BMJ Open. 2023; 13(3): e065400. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-065400

PMCID:: PMC10016264

Abstract Article PDF–703K

Social ecological factors and medication treatment for opioid use disorder among justice-involved rural and urban persons: the Geographic variation in Addiction Treatment Experiences (GATE) longitudinal cohort study protocol

Carrie B Oser, Evan Batty, Marisa Booty, Kate Eddens, Hannah K Knudsen, Brea Perry, Maria Rockett, Michele Staton

BMJ Open. 2023; 13(3): e066068. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-066068

PMCID:: PMC10030549

Abstract Article PDF–506K

Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR): a protocol for a randomised controlled trial

Daniel Thaysen-Petersen, Sigurd Krogh Hammerum, Anne-Cathrine Vissing, Benjamin Thorup Arnfred, Rolf Nordahl, Ali Adjorlu, Merete Nordentoft, Irene Henriette Oestrich, Signe Wegmann Düring, Anders Fink-Jensen

BMJ Open. 2023; 13(3): e068658. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068658

PMCID:: PMC10069573

Abstract Article PDF–805K

Patients’ perceptions of self-administered dosing to opioid agonist treatment and other changes during the COVID-19 pandemic: a qualitative study

Gemma Scott, Sophie Turner, Natalie Lowry, Annette Hodge, Waniya Ashraf, Katie McClean, Mike Kelleher, Luke Mitcheson, John Marsden

BMJ Open. 2023; 13(3): e069857. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-069857

PMCID:: PMC10032386

Abstract Article PDF–347K

Anaesthesia

Quality contract ‘prevention of postoperative delirium in the care of elderly patients’ study protocol: a non-randomised, pre–post, monocentric, prospective trial

Fatima Yürek, Julian-Dominic Zimmermann, Elisa Weidner, Armin Hauß, Enrico Dähnert, Daniel Hadzidiakos, Jochen Kruppa, Joern Kiselev, Natia Sichinava, Oscar Andrés Retana Romero, Laerson Hoff, Rudolf Mörgeli, Lennart Junge, Kathrin Scholtz, Sophie K Piper, Luzie Grüner, Antonia Eva Maria Harborth, Lisa Eymold, Tuba Gülmez, Elke Falk, Felix Balzer, Sascha Treskatsch, Moritz Höft, Dieter Schmidt, Franziska Landgraf, Ursula Marschall, Andreas Hölscher, Mani Rafii, Claudia Spies

BMJ Open. 2023; 13(3): e066709. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-066709

PMCID:: PMC9990682

Abstract Article PDF–2.5M

Sensitivity of a preanaesthesia screening and triage tool in identifying high-risk patients attending the preanaesthesia assessment clinic in a tertiary referral hospital in Sub-Saharan Africa: a diagnostic accuracy study

Brian Misoi, Vitalis Mung'ayi, Rajpreet Bal, Shamshudin Mohammedali

BMJ Open. 2023; 13(3): e067603. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-067603

PMCID:: PMC10008346

Abstract Article PDF–255K

Temporal validation of a multivariable surgical mortality prediction model (NZRisk): a New Zealand national cohort study

Luke Boyle, Marta Seretny, Thomas Lumley, Doug Campbell

BMJ Open. 2023; 13(3): e069911. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-069911

PMCID:: PMC10069599

Abstract Article PDF–757K

Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis

Jonathan Barnes, Emma Sewart, Richard A Armstrong, Maria Pufulete, Robert Hinchliffe, Ben Gibbison, Ronelle Mouton

BMJ Open. 2023; 13(3): e069950. Published online 2023 Mar 29. doi: 10.1136/bmjopen-2022-069950

PMCID:: PMC10069576

Abstract Article PDF–451K

Intraoperative pharmacologic opioid minimisation strategies and patient-centred outcomes after surgery: a scoping review protocol

Michael Verret, Nhat Hung Lam, Dean A Fergusson, Stuart G Nicholls, Alexis F Turgeon, Daniel I McIsaac, Ian Gilron, Myriam Hamtiaux, Sriyathavan Srichandramohan, Abdulaziz Al-Mazidi, Nicholas A Fergusson, Brian Hutton, Fiona Zivkovic, Megan Graham, Allison Geist, Maxime Lê, Melanie Berube, Patricia Poulin, Risa Shorr, Helena Daudt, Guillaume Martel, Jason McVicar, Husein Moloo, Manoj M Lalu, the Perioperative Anesthesia Clinical Trials (PACT) group

BMJ Open. 2023; 13(3): e070748. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-070748

PMCID:: PMC9980324

Abstract Article PDF–640K

Cardiovascular Medicine

Development and internal validation of a clinical risk score for in-hospital mortality after stroke: a single-centre retrospective cohort study in Northwest Ethiopia

Tiruayehu Getinet Abebe, Sefineh Fenta Feleke, Anteneh Mengist Dessie, Rahel Mulatie Anteneh, Zelalem Alamrew Anteneh

BMJ Open. 2023; 13(3): e063170. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-063170

PMCID:: PMC10069517

Abstract Article PDF–501K

Primary care Adherence To Heart Failure guidelines IN Diagnosis, Evaluation and Routine management (PATHFINDER): a randomised controlled trial protocol

Liying Dai, Tashi Dorje, Jan Gootjes, Amit Shah, Lawrence Dembo, Jamie Rankin, Graham Hillis, Suzanne Robinson, John J Atherton, Angela Jacques, Christopher M Reid, Andrew Maiorana

BMJ Open. 2023; 13(3): e063656. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-063656

PMCID:: PMC10069547

Abstract Article PDF–565K

Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review

María Elena Mansilla-Rodríguez, Manuel J Romero-Jimenez, Alina Rigabert Sánchez-Junco, Eva Nadiedja Gutierrez-Cortizo, José Luis Sánchez-Ramos, Pedro Mata, Jing Pang, Gerald F Watts

BMJ Open. 2023; 13(3): e065551. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-065551

PMCID:: PMC10069512

Abstract Article PDF–309K

Protocol for a prospective cohort study exploring the gut microbiota of infants with congenital heart disease undergoing cardiopulmonary bypass (the GuMiBear study)

Claire Magner, Dominic Jenkins, Fatma Koc, Mong Hoi Tan, Molly O’Toole, Jordan Boyle, Niamh Maguire, Sophie Duignan, Kiera Murphy, Paul Ross, Catherine Stanton, Colin J McMahon

BMJ Open. 2023; 13(3): e067016. Published online 2023 Mar 31. doi: 10.1136/bmjopen-2022-067016

PMCID:: PMC10069492

Abstract Article PDF–268K

Multivariable prediction models for atrial fibrillation after cardiac surgery: a systematic review protocol

Kara G Fields, Jie Ma, Tatjana Petrinic, Hassan Alhassan, Anthony Eze, Ankith Reddy, Mona Hedayat, Rui Providencia, Gregory Y H Lip, Jonathan P Bedford, David A Clifton, Oliver C Redfern, Benjamin O’Brien, Peter J Watkinson, Gary S Collins, Jochen D Muehlschlegel

BMJ Open. 2023; 13(3): e067260. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-067260

PMCID:: PMC10016290

Abstract Article PDF–704K

Arterial hypertension and its covariates among nomadic Raute hunter-gatherers of Western Nepal: a mixed-method study

Tapendra Koirala, Udaya Bahadur B C, Carmina Shrestha, Ujjawal Paudel, Rolina Dhital, Sunil Pokharel, Madhusudan Subedi

BMJ Open. 2023; 13(3): e067312. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-067312

PMCID:: PMC10069499

Abstract Article PDF–1.1M

Prevalence of myocardial fibrosis among patients living with HIV and factors associated with a higher prevalence rate: protocol for a systematic review and meta-analysis

Saeed Shoar, Calvin D Dao, Noel M Higgason, Nasrin Shoar

BMJ Open. 2023; 13(3): e067350. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067350

PMCID:: PMC10016240

Abstract Article PDF–406K

Diagnostic accuracy of heart auscultation for detecting valve disease: a systematic review

Anne Herefoss Davidsen, Stian Andersen, Peder Andreas Halvorsen, Henrik Schirmer, Eirik Reierth, Hasse Melbye

BMJ Open. 2023; 13(3): e068121. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068121

PMCID:: PMC10040065

Abstract Article PDF–1.0M

Unravelling the link between periodontitis and abdominal aortic calcification in the US adult population: a cross-sectional study based on the NHANES 2013–2014

Kaisaierjiang Kadier, Anniwaer Abulizi, Aikeliyaer Ainiwaer, Rena Rehemuding, Xiang Ma, Yi-Tong Ma

BMJ Open. 2023; 13(3): e068931. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068931

PMCID:: PMC10030668

Abstract Article PDF–512K

Development and validation of dynamic models to predict postdischarge mortality risk in patients with acute myocardial infarction: results from China Acute Myocardial Infarction Registry

Junxing Lv, Chuangshi Wang, Xiaojin Gao, Jingang Yang, Xuan Zhang, Yunqing Ye, Qiuting Dong, Rui Fu, Hui Sun, Xinxin Yan, Yanyan Zhao, Yang Wang, Haiyan Xu, Yuejin Yang

BMJ Open. 2023; 13(3): e069505. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069505

PMCID:: PMC10069604

Abstract Article PDF–600K

Randomised controlled trial to evaluate the effect of contrast material dilution on renal function in patients after endovascular aortic repair: rationale and design for the CULTURE trial

Yuhang Zhou, Jiarong Wang, Jichun Zhao, Bin Huang, Ding Yuan, Tiehao Wang

BMJ Open. 2023; 13(3): e069804. Published online 2023 Mar 22. doi: 10.1136/bmjopen-2022-069804

PMCID:: PMC10040023

Abstract Article PDF–1.0M

Methods for assessing guideline adherence for invasive procedures in the care of chronic coronary artery disease: a scoping review

Hannah Kentenich, Dirk Müller, Bastian Wein, Stephanie Stock, Yana Seleznova

BMJ Open. 2023; 13(3): e069832. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-069832

PMCID:: PMC10030787

Abstract Article PDF–706K

Prospective observational study on the accuracy of predictors of high-grade atrioventricular conduction block after transcatheter aortic valve implantation (CONDUCT-TAVI): study protocol, background and significance

Karan Rao, Kunwardeep Bhatia, Bernard Chan, Mitchell Cowan, Natasha Saad, Alexandra Baer, Hari Sritharan, Ingrid Bromhead, David Whalley, Usaid K Allahwala, Peter Hansen, Ravinay Bhindi

BMJ Open. 2023; 13(3): e070219. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-070219

PMCID:: PMC10008405

Abstract Article PDF–597K

Communications

Protocol for the Pathways Study: a realist evaluation of staff social ties and communication in the delivery of neonatal care in Kenya

Conrad Wanyama, Claire Blacklock, Juliet Jepkosgei, Mike English, Lisa Hinton, Jacob McKnight, Sassy Molyneux, Mwanamvua Boga, Peris Muoga Musitia, Geoff Wong

BMJ Open. 2023; 13(3): e066150. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-066150

PMCID:: PMC10016238

Abstract Article PDF–883K

Evidence-guided approach to portfolio-guided teaching and assessing communications, ethics and professionalism for medical students and physicians: a systematic scoping review

Jacquelin Jia Qi Ting, Gillian Li Gek Phua, Daniel Zhihao Hong, Bertrand Kai Yang Lam, Annabelle Jia Sing Lim, Eleanor Jia Xin Chong, Anushka Pisupati, Rei Tan, Jocelyn Yi Huang Yeo, Yi Zhe Koh, Chrystie Wan Ning Quek, Jia Yin Lim, Kuang Teck Tay, Yun Ting Ong, Min Chiam, Jamie Xuelian Zhou, Stephen Mason, Limin Wijaya, Lalit Kumar Radha Krishna

BMJ Open. 2023; 13(3): e067048. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-067048

PMCID:: PMC10069516

Abstract Article PDF–776K

Complementary Medicine

Cross-sectional survey and Bayesian network model analysis of traditional Chinese medicine in Austria: investigating public awareness, usage determinants and perception of scientific support

Michael Eigenschink, Luise Bellach, Sebastian Leonard, Tom Eric Dablander, Julian Maier, Fabian Dablander, Harald H Sitte

BMJ Open. 2023; 13(3): e060644. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2021-060644

PMCID:: PMC9990654

Abstract Article PDF–1.5M

Acupuncture in chemotherapy-induced dysgeusia (AcuDysg): study protocol of a randomised controlled trial

Christine Huber, Linxin Zhang, Marc Schlaeppi, Twyla Müller, Stephanie Roll, Petra Voiss, Jürgen Barth, Christoph Driessen, Claudia M Witt

BMJ Open. 2023; 13(3): e066137. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066137

PMCID:: PMC10008328

Abstract Article PDF–547K

Efficacy of mecobalamin (vitamin B₁₂) in the treatment of long-term pain in women diagnosed with fibromyalgia: protocol for a randomised, placebo-controlled trial

Karin Sall Hansson, Gunilla Lindqvist, Kent Stening, Jan Fohlman, Anna Wojanowski, Moa Ponten, Karin Jensen, Björn Gerdle, Carina Elmqvist

BMJ Open. 2023; 13(3): e066987. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-066987

PMCID:: PMC10069488

Abstract Article PDF–410K

Efficacy and safety of acupuncture for postpartum hypogalactia: protocol for a systematic review and meta-analysis

Qiong-Nan Bao, Yuan-Fang Zhou, Zi-Han Yin, Qiu Bi, Hong-Bin Zhao, Zhen-Yong Zhang, Fan-Rong Liang

BMJ Open. 2023; 13(3): e068224. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-068224

PMCID:: PMC10008430

Abstract Article PDF–505K

Dentistry and Oral Medicine

Interaction of Systemic Morbidity and Oral Health in Ambulatory Patients in Need of Home Care (InSEMaP): an observational study at the sector boundary between dental and general practice care in Germany

Thomas Zimmermann, Alena Koenig, Sarah Porzelt, Petra Schmage, Claudia Konnopka, Stefanie Schellhammer, Anja Behrens-Potratz, Edelqueen Ijeoma Okoro, Espen Henken, Peter Stratmeyer, Thomas Beikler, Hans-Helmut König, Martin Scherer, Alexander Konnopka

BMJ Open. 2023; 13(3): e063685. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-063685

PMCID:: PMC10016254

Abstract Article PDF–1.0M

Association between periodontitis and hypertension: cross-sectional survey from the Fourth National Oral Health Survey of China (2015–2016)

Yalin Zhan, Jian Jiao, Wudi Jing, Xiping Feng, Baojun Tai, Deyu Hu, Huan-cai Lin, Bo Wang, Chunxiao Wang, Shuguo Zheng, Xuenan Liu, Wensheng Rong, Weijian Wang, Xing Wang, Yan Si, Huanxin Meng

BMJ Open. 2023; 13(3): e068724. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-068724

PMCID:: PMC10069577

Abstract Article PDF–406K

Dermatology

Clinical trial on the efficacy and safety of NPC-15 for patients with xeroderma pigmentosum exaggerated sunburn reaction type: XP-1 study protocol for a multicentre, double-blinded, placebo-controlled, two-group crossover study followed by a long-term open study in Japan

Mariko Tsujimoto, Yasumasa Kakei, Nozomi Yamano, Takeshi Fujita, Takehiro Ueda, Ryusuke Ono, Sae Murakami, Shinichi Moriwaki, Chikako Nishigori

BMJ Open. 2023; 13(3): e068112. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068112

PMCID:: PMC10040004

Abstract Article PDF–405K

Rates of malignancies among patients with moderate to severe atopic dermatitis: a retrospective cohort study

Monique M Hedderson, Maryam M Asgari, Fei Xu, Charles P Quesenberry, Sneha Sridhar, Jamie Geier, Adina R Lemeshow

BMJ Open. 2023; 13(3): e071172. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-071172

PMCID:: PMC10008325

Abstract Article PDF–762K

Diabetes and Endocrinology

Ramadan fasting and type 1 diabetes: a scoping review protocol

Ali Tootee, Fatemeh Bandarian, Nazli Namazi, Rasha Atlasi, Bagher Larijani

BMJ Open. 2023; 13(3): e058847. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2021-058847

PMCID:: PMC10016270

Abstract Article PDF–250K

Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis

Hong Ma, Yu-Hao Lin, Li-Zhen Dai, Chen-Shi Lin, Yanling Huang, Shu-Yuan Liu

BMJ Open. 2023; 13(3): e061807. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-061807

PMCID:: PMC10008474

Abstract Article PDF–3.4M

Seasonal variation in gestational diabetes mellitus among women in Norway: a national population-based study

Astrid Melteig Stalheim, Marjolein Memelink Iversen, Anne Karen Jenum, Line Sletner, Signe N Stafne, Elisabeth Qvigstad, Linda Sagedal, Roy Miodini Nilsen, Vigdis Aasheim, Ragnhild B Strandberg

BMJ Open. 2023; 13(3): e063725. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-063725

PMCID:: PMC10016255

Abstract Article PDF–514K

Characterising the burden of chronic kidney disease among people with type 2 diabetes in England: a cohort study using the Clinical Practice Research Datalink

Sarah Cook, Niklas Schmedt, Julie Broughton, Philip A Kalra, Laurie A Tomlinson, Jennifer K Quint

BMJ Open. 2023; 13(3): e065927. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-065927

PMCID:: PMC10008473

Abstract Article PDF–355K

Sodium glucose co-transporter 2 inhibition with empagliflozin on metabolic, cardiac and renal outcomes in recent cardiac transplant recipients (EMPA-HTx): protocol for a randomised controlled trial

Lisa Mary Raven, Christopher A Muir, Cassia Kessler Iglesias, Nicole K Bart, Kavitha Muthiah, Eugene Kotlyar, Peter Macdonald, Christopher S Hayward, Andrew Jabbour, Jerry R Greenfield

BMJ Open. 2023; 13(3): e069641. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069641

PMCID:: PMC10069602

Abstract Article PDF–269K

Diagnostics

Using pooled urogenital, anorectal and oropharyngeal specimens to detect Chlamydia trachomatis and Neisseria gonorrhoeae among men who have sex with men in China: a multisite diagnostic accuracy study

Ting-Ting Jiang, Ning-Xiao Cao, Mei-Qin Shi, Tian-Jian Jia, Qian Zhou, Jing-Wei Liu, Jin Zhang, Yan Zhang, Yue-Ping Yin, Xiang-Sheng Chen

BMJ Open. 2023; 13(3): e069876. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-069876

PMCID:: PMC9990619

Abstract Article PDF–730K

Ear, Nose and Throat/Otolaryngology

Vestibular syndromes, diagnosis and diagnostic errors in patients with dizziness presenting to the emergency department: a cross-sectional study

Lukas Comolli, Athanasia Korda, Ewa Zamaro, Franca Wagner, Thomas C Sauter, Marco D Caversaccio, Florence Nikles, Simon Jung, Georgios Mantokoudis

BMJ Open. 2023; 13(3): e064057. Published online 2023 Mar 24. doi: 10.1136/bmjopen-2022-064057

PMCID:: PMC10040076

Abstract Article PDF–292K

Impact of hearing impairment and cochlear implantation on productivity and social well-being in a professionally active but severely hearing-impaired group: protocol of the ‘Hear again, work again’ longitudinal prospective cohort study

Cato Philips, Laure Jacquemin, Marc JW Lammers, Kristien Wouters, Julie Moyaert, Olivier Vanderveken, Vincent Van Rompaey

BMJ Open. 2023; 13(3): e064514. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-064514

PMCID:: PMC10008330

Abstract Article PDF–323K

Comparison of hearing aid fitting effectiveness with audiograms from either user-operated or traditional audiometry in a clinical setting: a study protocol for a blinded non-inferiority randomised controlled trial

Carl Christian Pedersen, Ellen Raben Pedersen, Søren Laugesen, Raul Sanchez-Lopez, Jacob Nielsen, Chris Bang Sørensen, Christos Sidiras, René Gyldenlund Pedersen, Jesper Hvass Schmidt

BMJ Open. 2023; 13(3): e065777. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-065777

PMCID:: PMC9990669

Abstract Article PDF–422K

Associations between autistic traits and early ear and upper respiratory signs: a prospective observational study of the Avon Longitudinal Study of Parents and Children (ALSPAC) geographically defined childhood population

Amanda Hall, Richard Maw, Yasmin Iles-Caven, Steven Gregory, Dheeraj Rai, Jean Golding

BMJ Open. 2023; 13(3): e067682. Published online 2023 Feb 21. doi: 10.1136/bmjopen-2022-067682

PMCID:: PMC10186415

Abstract Article PDF–345K

Emergency Medicine

Effect of ED-based transitional care interventions by healthcare professionals providing transitional care in the emergency department on clinical, process and service use outcomes: a systematic review

Steef van den Broek, Gert P Westert, Gijs Hesselink, Yvonne Schoon

BMJ Open. 2023; 13(3): e066030. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066030

PMCID:: PMC10016244

Abstract Article PDF–680K

Subanaesthetic single-dose ketamine as an adjunct to opioid analgesics for acute pain management in the emergency department: a systematic review and meta-analysis

Stine Fjendbo Galili, Lone Nikolajsen, Nicholas Papadomanolakis-Pakis

BMJ Open. 2023; 13(3): e066444. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-066444

PMCID:: PMC10069507

Abstract Article PDF–2.1M

Engaging emergency medical services to improve postacute management of behavioural health emergency calls: a protocol of a scoping literature review

Marissa L Ding, Danielle J Gerberi, Rozalina G McCoy

BMJ Open. 2023; 13(3): e067272. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-067272

PMCID:: PMC10016281

Abstract Article PDF–305K

Pharmacological emergency management of agitation in children and young people: protocol for a randomised controlled trial of oral medication (PEAChY-O)

Elyssia M Bourke, Meredith L Borland, Amit Kochar, Shane George, Deborah Shellshear, Shefali Jani, Kent Perkins, Doris Tham, Michael Solomon Gordon, Kate Klein, Chidambaram Prakash, Katherine Lee, Andrew Davidson, Jonathan C Knott, Simon Craig, Franz E Babl

BMJ Open. 2023; 13(3): e067433. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-067433

PMCID:: PMC10069548

Abstract Article PDF–891K

Pharmacological Emergency management of Agitation in Children and Young people: protocol for a randomised controlled trial of intraMuscular medication (PEAChY-M)

BMJ Open. 2023; 13(3): e067436. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-067436

PMCID:: PMC10069493

Abstract Article PDF–897K

Towards exploring current challenges and future opportunities relating to the prehospital triage of patients with traumatic brain injury: a mixed-methods study protocol

Naif Alqurashi, Ahmed Alotaibi, Steve Bell, Fiona Lecky, Richard Body

BMJ Open. 2023; 13(3): e068555. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-068555

PMCID:: PMC10008429

Abstract Article PDF–489K

Volunteer responder provision of support to relatives of out-of-hospital cardiac arrest patients: a qualitative study

Astrid Rolin Kragh, Anne Juul Grabmayr, Tine Tjørnhøj-Thomsen, Line Zinckernagel, Mads Christian Tofte Gregers, Linn Charlotte Andelius, Anders Korsgaard Christensen, Jesper Kjærgaard, Fredrik Folke, Carolina Malta Hansen

BMJ Open. 2023; 13(3): e071220. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-071220

PMCID:: PMC10032384

Abstract Article PDF–319K

Effects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial

Thimo Marcin, Stefanie C Hautz, Hardeep Singh, Laura Zwaan, David Schwappach, Gert Krummrey, Stefan K Schauber, Mathieu Nendaz, Aristomenis Konstantinos Exadaktylos, Martin Müller, Cornelia Lambrigger, Thomas C Sauter, Gregor Lindner, Simon Bosbach, Ines Griesshammer, Wolf E Hautz

BMJ Open. 2023; 13(3): e072649. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2023-072649

PMCID:: PMC10069571

Abstract Article PDF–637K

Epidemiology

Examining non-linearity in the association between age and reported opioid use in different socioeconomic strata: cohort study using Health Survey for England waves from 1997 to 2014

Magdalena Nowakowska, Salwa S Zghebi, Li-Chia Chen, Darren M Ashcroft, Evangelos Kontopantelis

BMJ Open. 2023; 13(3): e057428. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2021-057428

PMCID:: PMC9980331

Abstract Article PDF–1.9M

Trends in healthcare utilisation of patients with migraine in South Korea: a retrospective observational study using Health Insurance Review and Assessment Service National Patient Sample data from 2010 to 2018

Sookyung Lee, Jiyoon Yeo, Sook-Hyun Lee, Yoon Jae Lee, Sangkwan Lee, In-Hyuk Ha

BMJ Open. 2023; 13(3): e059926. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2021-059926

PMCID:: PMC10032417

Abstract Article PDF–1.7M

Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study

Sandra Florian, Mathieu Ichou, Lidia Panico, Stéphanie Pinel-Jacquemin, Tanja G M Vrijkotte, Margreet W Harskamp-van Ginkel, Rae-Chi Huang, Jennie Carson, Loreto Santa Marina Rodriguez, Mikel Subiza-Pérez, Martine Vrijheid, Sílvia Fernández-Barrés, Tiffany C Yang, John Wright, Eva Corpeleijn, Marloes Cardol, Elena Isaevska, Chiara Moccia, Marjolein N Kooijman, Ellis Voerman, Vincent Jaddoe, Marieke Welten, Elena Spada, Marisa Rebagliato, Andrea Beneito, Luca Ronfani, Marie-Aline Charles

BMJ Open. 2023; 13(3): e060932. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-060932

PMCID:: PMC10040079

Abstract Article PDF–819K

Day-to-day variability of knee pain and the relationship with physical activity in people with knee osteoarthritis: an observational, feasibility study using consumer smartwatches

Arani Vivekanantham, David Selby, Mark Lunt, Jamie C Sergeant, Matthew J Parkes, Terence W O'Neill, Will Dixon

BMJ Open. 2023; 13(3): e062801. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-062801

PMCID:: PMC10016308

Abstract Article PDF–1002K

Loss to 5-year follow-up in the population-based Telemark Study: risk factors and potential for bias

Nikola Zivadinovic, Regine Abrahamsen, Maiju Pesonen, Anthony Wagstaff, Kjell Torén, Paul K Henneberger, Johny Kongerud, Anne Kristin Moeller Fell

BMJ Open. 2023; 13(3): e064311. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-064311

PMCID:: PMC10069543

Abstract Article PDF–542K

Prevalence and associated factors for prehypertension and hypertension among Indonesian adolescents: a cross-sectional community survey

Sudikno Sudikno, Rofingatul Mubasyiroh, Rika Rachmalina, Prisca Petty Arfines, Tities Puspita

BMJ Open. 2023; 13(3): e065056. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-065056

PMCID:: PMC10040007

Abstract Article PDF–318K

Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019

Rui Wang, Zhaoqi Li, Shaojun Liu, Decai Zhang

BMJ Open. 2023; 13(3): e065186. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-065186

PMCID:: PMC10069527

Abstract Article PDF–4.2M

Common mental health and emotional and behavioural disorders among adolescents and young adults in Harare and Mashonaland East, Zimbabwe: a population-based prevalence study

Aoife Margaret Doyle, T Bandason, E Dauya, Grace McHugh, Chris Grundy, Victoria Simms, D Chibanda, Rashida Ferrand

BMJ Open. 2023; 13(3): e065276. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-065276

PMCID:: PMC10016291

Abstract Article PDF–435K

Association between exposure to secondhand aerosol from heated tobacco products and respiratory symptoms among current non-smokers in Japan: a cross-sectional study

Takashi Yoshioka, Tomohiro Shinozaki, Ai Hori, Sumiyo Okawa, Kei Nakashima, Takahiro Tabuchi

BMJ Open. 2023; 13(3): e065322. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-065322

PMCID:: PMC10008163

Abstract Article PDF–647K

Recording type 2 diabetes mellitus in a standardised central Saudi database: a retrospective validation study

Turki Abdulaziz Althunian, Meshael M Alrasheed, Fatemah A Alnofal, Rawan T Tafish, Mahmood A Mira, Raseel A Alroba, Mohammed W Kirdas, Thamir M Alshammari

BMJ Open. 2023; 13(3): e065468. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-065468

PMCID:: PMC10032409

Abstract Article PDF–280K

Cohort profile – the Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study in the Netherlands

Jake S F Maurits, J P Michiel Sedelaar, Katja K H Aben, Ellen Kampman, The ReLife study group, Lambertus A L M Kiemeney, Alina Vrieling

BMJ Open. 2023; 13(3): e066909. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-066909

PMCID:: PMC10069500

Abstract Article PDF–672K

International modified Delphi study on malaria preventive behaviour: new themes, contexts and framework for future research on Plasmodium knowlesi malaria

Nurul Athirah Naserrudin, Rozita Hod, Mohammad Saffree Jeffree, Kamruddin Ahmed, Mohd Rohaizat Hassan

BMJ Open. 2023; 13(3): e067451. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-067451

PMCID:: PMC10008207

Abstract Article PDF–1.2M

Identifying the prevalence and correlates of multimorbidity in middle-aged men and women: a cross-sectional population-based study in four African countries

Lisa K Micklesfield, Richard Munthali, Godfred Agongo, Gershim Asiki, Palwende Boua, Solomon SR Choma, Nigel J Crowther, June Fabian, Francesc Xavier Gómez-Olivé, Chodziwadziwa Kabudula, Eric Maimela, Shukri F Mohamed, Engelbert A Nonterah, Frederick J Raal, Hermann Sorgho, Furahini D Tluway, Alisha N Wade, Shane A Norris, Michele Ramsay

BMJ Open. 2023; 13(3): e067788. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067788

PMCID:: PMC10016250

Abstract Article PDF–2.0M

Associations between older adults’ physical fitness level and their engagement in different types of physical activity: cross-sectional results from the OUTDOOR ACTIVE study

Birte Marie Albrecht, Imke Stalling, Carina Recke, Friederike Doerwald, Karin Bammann

BMJ Open. 2023; 13(3): e068105. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068105

PMCID:: PMC10069498

Abstract Article PDF–326K

Association of red cell distribution width (RDW) and the RDW to platelet count ratio with cardiovascular disease among US adults: a cross-sectional study based on the National Health and Nutrition Examination Survey 1999–2020

Aikeliyaer Ainiwaer, Kaisaierjiang Kadier, Anniwaer Abulizi, Wen Qing Hou, Rena Rehemuding, Halimulati Maimaiti, Mubalake Yakufu, Xiang Ma, Yi-Tong Ma

BMJ Open. 2023; 13(3): e068148. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-068148

PMCID:: PMC10016283

Abstract Article PDF–819K

Investigation of SARS-CoV-2 seroprevalence in relation to natural infection and vaccination between October 2020 and September 2021 in the Czech Republic: a prospective national cohort study

Vojtěch Thon, Pavel Piler, Tomáš Pavlík, Lenka Andrýsková, Kamil Doležel, David Kostka, Hynek Pikhart, Martin Bobák, Jana Klánová

BMJ Open. 2023; 13(3): e068258. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-068258

PMCID:: PMC10008433

Abstract Article PDF–321K

Linking population-based cohorts with cancer registries in LMIC: a case study and lessons learnt in India

Aastha Aggarwal, Ranganathan Rama, Preet K Dhillon, Mohan Deepa, Dimple Kondal, Naveen Kaushik, Dipika Bumb, Ravi Mehrotra, Betsy A Kohler, Viswanathan Mohan, Theresa W Gillespie, Alpa V Patel, Swaminathan Rajaraman, Dorairaj Prabhakaran, Kevin C Ward, Michael Goodman

BMJ Open. 2023; 13(3): e068644. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-068644

PMCID:: PMC9990691

Abstract Article PDF–1.0M

Association between seropositivity for toxocariasis and cognitive functioning in older adults: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES), 2011–2014

Ge Song, Chao Yang, Zhe Qu, Xuechun Lin, Minhui Liu, Yanhong Wang

BMJ Open. 2023; 13(3): e068974. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-068974

PMCID:: PMC9980365

Abstract Article PDF–374K

Comparison of social gradient in cardiometabolic health in Czechia and Venezuela: a cross-sectional study

Anna Bartoskova Polcrova, Ramfis Nieto-Martinez, Jeffrey I Mechanick, Geraldo A Maranhao Neto, Maria M Infante-Garcia, Hynek Pikhart, Martin Bobak, Jose Medina-Inojosa, Juan P Gonzalez-Rivas

BMJ Open. 2023; 13(3): e069077. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-069077

PMCID:: PMC10030916

Abstract Article PDF–765K

Association between maternal multimorbidity and preterm birth, low birth weight and small for gestational age: a prospective birth cohort study from the Japan Environment and Children’s Study

Kentaro Nakanishi, Yasuaki Saijo, Eiji Yoshioka, Yukihiro Sato, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi

BMJ Open. 2023; 13(3): e069281. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-069281

PMCID:: PMC10030623

Abstract Article PDF–489K

Prevalence and associated factors of diabetes mellitus among patients with tuberculosis in South Korea from 2011 to 2018: a nationwide cohort study

Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang

BMJ Open. 2023; 13(3): e069642. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-069642

PMCID:: PMC10008237

Abstract Article PDF–660K

Prescription drugs with potential for misuse: protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020

Gráinne Cousins, Louise Durand, Aoife O’Kane, Julie Tierney, Richard Maguire, Siobhán Stokes, Deirdre O’Reilly, Ella Arensman, Kathleen E Bennett, María Otero Vázquez, Paul Corcoran, Suzi Lyons, Yvonne Kavanagh, Eamon Keenan

BMJ Open. 2023; 13(3): e069665. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-069665

PMCID:: PMC9990618

Abstract Article PDF–404K

Household structure, composition and child mortality in the unfolding antiretroviral therapy era in rural South Africa: comparative evidence from population surveillance, 2000–2015

Brian Houle, Chodziwadziwa Kabudula, Dickman Gareta, Kobus Herbst, Samuel J Clark

BMJ Open. 2023; 13(3): e070388. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-070388

PMCID:: PMC10030929

Abstract Article PDF–1.1M

Ethics

Evaluating a clinical ethics committee (CEC) implementation process in an oncological research hospital: protocol for a process evaluation study using normalisation process theory (EvaCEC)

Marta Perin, Morten Magelssen, Luca Ghirotto, Ludovica De Panfilis

BMJ Open. 2023; 13(3): e067335. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-067335

PMCID:: PMC10008162

Abstract Article PDF–306K

Public reporting of clinical trial findings as an ethical responsibility to participants: a qualitative study

Richard L Morrow, Barbara Mintzes, Garry Gray, Michael R Law, Scott Garrison, Colin R Dormuth

BMJ Open. 2023; 13(3): e068221. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068221

PMCID:: PMC10032397

Abstract Article PDF–343K

Evidence Based Practice

Can we streamline the concepts of knowledge translation, dissemination and implementation for lay stakeholders? A perspective

Lubna Daraz, Khondoker Golam Morshed

BMJ Open. 2023; 13(3): e068946. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068946

PMCID:: PMC10040022

Abstract Article PDF–408K

Developing a best practice framework for musculoskeletal outpatient physiotherapy delegation: the MOPeD mixed-methods research study protocol

Panos Sarigiovannis, Nadine E Foster, Sue Jowett, Benjamin Saunders

BMJ Open. 2023; 13(3): e072989. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2023-072989

PMCID:: PMC10030620

Abstract Article PDF–487K

Gastroenterology and Hepatology

Impact of Helicobacter pylori on the gastric microbiome in patients with chronic gastritis: a systematic review and meta-analysis protocol

Xinyuan Cao, Yingyun Yang, Yizhen Zhang, Ruoyu Ji, Xinyu Zhao, Weiyang Zheng, Aiming Yang

BMJ Open. 2023; 13(3): e050476. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2021-050476

PMCID:: PMC10030478

Abstract Article PDF–277K

Intravenous ferric carboxymaltose versus oral ferrous sulfate replacement in elderly patients after acute non-variceal gastrointestinal bleeding (FIERCE): protocol of a multicentre, open-label, randomised controlled trial

Brigitta Teutsch, Szilárd Váncsa, Nelli Farkas, Zsolt Szakács, Nóra Vörhendi, Eszter Boros, Imre Szabó, Roland Hágendorn, Hussain Alizadeh, Péter Hegyi, Bálint Erőss

BMJ Open. 2023; 13(3): e063554. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-063554

PMCID:: PMC10016295

Abstract Article PDF–483K

Effects of ileocolonic delivered vitamin B₂, B₃ and C (ColoVit) or the Groningen anti-inflammatory diet on disease course and microbiome of patients with Crohn’s disease (VITA-GrAID study): a protocol for a randomised and partially blinded trial

Antonius Timotheus Otten, V Peters, I Barth, C L Stevens, A R Bourgonje, H W Frijlink, H J M Harmsen, A Rehman, M J E Campmans-Kuijpers, G Dijkstra

BMJ Open. 2023; 13(3): e069654. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-069654

PMCID:: PMC10016306

Abstract Article PDF–444K

Neostigmine for the treatment of acute pancreatitis: a protocol for a systematic review and meta-analysis

Kun He, Xiaxiao Yan, Zihan Yang, Yuelun Zhang, Huijun Shu, Dong Wu

BMJ Open. 2023; 13(3): e070289. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-070289

PMCID:: PMC10040008

Abstract Article PDF–324K

Acupuncture for Crohn’s disease: a protocol for systematic review and meta-analysis

Qiang Han, Daming Liu, Peng Zhang

BMJ Open. 2023; 13(3): e070578. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-070578

PMCID:: PMC10030788

Abstract Article PDF–510K

Assessment of a primary care e-support package of automated case finding, simplified treatment algorithm and decision support to increase hepatitis B treatment uptake in primary care clinics in Australia (SIMPLY-B Study): protocol for a pilot evaluation

Dina Moussa, Jack Wallace, Jo-Anne Manski-Nankervis, Joseph S Doyle, Long Nguyen, Douglas Boyle, Mark A Stoové, Jason Asselin, Zina Valaydon, Marvad Ahad, Susanne Glasgow, Kate New, Jane S Hocking, Lena Sanci, Alexander Thompson, Margaret Hellard, Jess Howell

BMJ Open. 2023; 13(3): e070663. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-070663

PMCID:: PMC10030932

Abstract Article PDF–355K

General practice / Family practice

Consequences of early thyroid ultrasound on subsequent tests, morbidity and costs: an explorative analysis of routine health data from German ambulatory care

Susann Hueber, Valeria Biermann, Johanna Tomandl, Lisette Warkentin, Angela Schedlbauer, Harald Tauchmann, David Klemperer, Maria Lehmann, Ewan Donnachie, Thomas Kühlein

BMJ Open. 2023; 13(3): e059016. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2021-059016

PMCID:: PMC10008444

Abstract Article PDF–1.0M

Factors associated with undertriage and overtriage in telephone triage in Danish out-of-hours primary care: a natural quasi-experimental cross-sectional study of randomly selected and high-risk calls

Dennis Schou Graversen, Anette Fischer Pedersen, Morten Bondo Christensen, Fredrik Folke, L Huibers

BMJ Open. 2023; 13(3): e064999. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-064999

PMCID:: PMC10030474

Abstract Article PDF–678K

Things I need you to know: a qualitative analysis of advice-giving statements in early-onset colorectal cancer patients’ personal accounts published online

Klay Lamprell, Diana Fajardo-Pulido, Gaston Arnolda, Syeda Somyyah Owais, Bróna Nic Giolla Easpaig, Yvonne Tran, Winston Liauw, Jeffrey Braithwaite

BMJ Open. 2023; 13(3): e068073. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068073

PMCID:: PMC10040059

Abstract Article PDF–608K

Association between patient complexity and healthcare costs in primary care on a Japanese island: a cross-sectional study

Yoshifumi Sugiyama, Rieko Mutai, Masato Matsushima

BMJ Open. 2023; 13(3): e068497. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068497

PMCID:: PMC10040045

Abstract Article PDF–1.0M

Understanding the healthcare providers’ perspective for bringing the assessment of burden of chronic conditions tool to practice: a protocol for an implementation study

Danny Claessens, Marcia Vervloet, Esther Adriana Boudewijns, Lotte C E M Keijsers, Annerika H M Gidding-Slok, Onno C P van Schayck, Liset van Dijk

BMJ Open. 2023; 13(3): e068603. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-068603

PMCID:: PMC9990614

Abstract Article PDF–843K

General practitioners’ perspectives on the management of refugee health: a qualitative study

Rachel Davison, Megan Hobbs, Frances Quirk, Michelle Guppy

BMJ Open. 2023; 13(3): e068986. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068986

PMCID:: PMC10039989

Abstract Article PDF–316K

Geriatric Medicine

Education mediating the associations between early life factors and frailty: a cross-sectional study of the UK Biobank

Asri Maharani, Altug Didikoglu, Terence W O'Neill, Neil Pendleton, Maria Mercè Canal, Antony Payton

BMJ Open. 2023; 13(3): e057511. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2021-057511

PMCID:: PMC9990643

Abstract Article PDF–336K

Effect of multimodal comprehensive communication skills training with video analysis by artificial intelligence for physicians on acute geriatric care: a mixed-methods study

Masaki Kobayashi, Mitsuya Katayama, Tomofumi Hayashi, Takuhiro Hashiyama, Toshinori Iyanagi, Saki Une, Miwako Honda

BMJ Open. 2023; 13(3): e065477. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-065477

PMCID:: PMC9990644

Abstract Article PDF–626K

Validation of quality indicators for evaluating geriatric pharmacotherapy services in primary care: a mixed methods study

Noriko Sato, Kenji Fujita, Hiroshi Okada, Kazuki Kushida, Timothy F Chen

BMJ Open. 2023; 13(3): e066665. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-066665

PMCID:: PMC10040050

Abstract Article PDF–4.2M

Course of fear of falling after hip fracture: findings from a 12-month inception cohort

Maaike N Scheffers-Barnhoorn, Miriam L Haaksma, Wilco P Achterberg, Arthur HP Niggebrugge, Max PL van der Sijp, Jolanda CM van Haastregt, Monica van Eijk

BMJ Open. 2023; 13(3): e068625. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068625

PMCID:: PMC10016251

Abstract Article PDF–1.1M

Frail2Fit study protocol: a feasibility and acceptability study of a virtual multimodal intervention delivered by volunteers to improve functional outcomes in older adults with frailty after discharge from hospital

Samantha Jane Meredith, Helen Roberts, Michael P W Grocott, Sandy Jack, Jane Murphy, Judit Varkonyi-Sepp, Andrew Bates, Stephen Eu Ruen Lim

BMJ Open. 2023; 13(3): e069533. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-069533

PMCID:: PMC10030662

Abstract Article PDF–426K

Global Health

Development of the Demographic Dividend Effort Index, a novel tool to measure existing efforts to create a favourable environment to harness a demographic dividend: results from an experts’ survey from six sub-Saharan African countries

Jean Christophe Rusatira, Carolina Cardona, Michelle Martinez-Baack, Jose G Rimon, Saifuddin Ahmed

BMJ Open. 2023; 13(3): e059937. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2021-059937

PMCID:: PMC10040031

Abstract Article PDF–412K

Evaluation of frameworks demonstrating the role of private sector in non-communicable disease management and control: a systematic review and thematic synthesis

Nadia Amin Somani, Keiko Marshall, Hammad Durrani, Kun Tang, Roman Mogilevskii, Zulfiqar Bhutta

BMJ Open. 2023; 13(3): e061370. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-061370

PMCID:: PMC9990678

Abstract Article PDF–1008K

Scoping review protocol to map evidence on South-South learning exchange in family planning

Komal Preet Allagh, James Kiarie, Isotta Triulzi, Rita Kabra

BMJ Open. 2023; 13(3): e061685. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-061685

PMCID:: PMC10040009

Abstract Article PDF–264K

Female adolescents’ knowledge and acceptability of human papillomavirus vaccine in Debre Tabor Town, Ethiopia: a cross-sectional study

Gedefaye Nibret Mihretie, Tewachew Muche Liyeh, Alemu Degu Ayele, Habtamu Gebrehana Belay, Tigist Seid Yimer, Agernesh Dereje Miskr, Bekalu Getnet Kassa, Adanech Getie Tefera, Enyew Dagnaw, Yismaw Yimam Belachew, Gebrehiwot Ayalew Tiruneh, Worku Necho Asferi, Sisay Getu, Tigabu Munye Aytenew

BMJ Open. 2023; 13(3): e061813. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-061813

PMCID:: PMC10040052

Abstract Article PDF–925K

Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019

Xiaojin Feng, Ningning Hou, Zhenna Chen, Jing Liu, Xue Li, Xiaodong Sun, Yongping Liu

BMJ Open. 2023; 13(3): e064540. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-064540

PMCID:: PMC10030786

Abstract Article PDF–4.9M

Is Nigeria on course to achieve universal health coverage in the context of its epidemiological and financing transition? A knowledge, capacity and policy gap analysis (a qualitative study)

Yewande Kofoworola Ogundeji, Oluwabambi Tinuoye, Ipchita Bharali, Wenhui Mao, Kelechi Ohiri, Osondu Ogbuoji, Nneka Orji, Gavin Yamey

BMJ Open. 2023; 13(3): e064710. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-064710

PMCID:: PMC10008219

Abstract Article PDF–325K

Improving family functioning and reducing violence in the home in North Kivu, Democratic Republic of Congo: a pilot cluster-randomised controlled trial of Safe at Home

Kathryn L Falb, Khudejha Asghar, Alexandra Blackwell, Simon Baseme, Martin Nyanguba, Danielle Roth, Jean de Dieu Hategekimana

BMJ Open. 2023; 13(3): e065759. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-065759

PMCID:: PMC10016303

Abstract Article PDF–514K

Barriers and facilitators influencing parent–adolescent communication on sexual and reproductive health in Indigenous communities in Latin American countries: protocol for a scoping review

Diana Carolina Chaparro Buitrago, Juan Pimentel

BMJ Open. 2023; 13(3): e066416. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066416

PMCID:: PMC10008420

Abstract Article PDF–296K

Rapid methods for identifying barriers and solutions to improve access to community health services: a scoping review protocol

Luke Nelson Allen, Hagar Azab, Ronald Jonga, Iris Gordon, Sarah Karanja, Jennifer Evans, Nam Thaker, Jacqueline Ramke, Andrew Bastawrous

BMJ Open. 2023; 13(3): e066804. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066804

PMCID:: PMC10008441

Abstract Article PDF–304K

Mindfulness-based programmes and ‘bigger than self’ issues: protocol for a scoping review

Robert John Callen-Davies, Jamie Bristow, Taranah Gazder, Gemma M Griffith, Yasmin Noorani, Rebecca Susan Crane

BMJ Open. 2023; 13(3): e067819. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067819

PMCID:: PMC10030572

Abstract Article PDF–344K

Sex differences in non-communicable disease multimorbidity among adults aged 45 years or older in India

Santosh Kumar Sharma, Devaki Nambiar, Arpita Ghosh

BMJ Open. 2023; 13(3): e067994. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-067994

PMCID:: PMC10069553

Abstract Article PDF–1.2M

Effectiveness of digital adherence technologies in improving tuberculosis treatment outcomes in four countries: a pragmatic cluster randomised trial protocol

Degu Jerene, Jens Levy, Kristian van Kalmthout, Job van Rest, Christopher Finn McQuaid, Matthew Quaife, Salome Charalambous, Katya Gamazina, A M Celina Garfin, Liberate Mleoh, Yana Terleieva, Alexsey Bogdanov, Noriah Maraba, Katherine Fielding

BMJ Open. 2023; 13(3): e068685. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068685

PMCID:: PMC10016242

Abstract Article PDF–573K

Global HIV prevention, care and treatment services for children: a cross-sectional survey from the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium

Rachel C Vreeman, Constantin T Yiannoutsos, Nik Khairulddin Nik Yusoff, C William Wester, Andrew Edmonds, Susan Ofner, Mary-Ann Davies, Valériane Leroy, Pagakrong Lumbiganon, Regina Célia de Menezes Succi, Christella Twizere, Steven Brown, Carolyn Bolton-Moore, Ounoo Elom Takassi, Michael Scanlon, Roxanne Martin, Kara Wools-Kaloustian

BMJ Open. 2023; 13(3): e069399. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-069399

PMCID:: PMC10016275

Abstract Article PDF–552K

HIV/AIDS

Prevalence of human immunodeficiency virus (HIV) among pregnant women in Nigeria: a systematic review and meta-analysis

Christian Onyedikachi Ozim, Rahini Mahendran, Mahendran Amalan, Shuby Puthussery

BMJ Open. 2023; 13(3): e050164. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2021-050164

PMCID:: PMC9980359

Abstract Article PDF–4.3M

Service delivery models that promote linkages to PrEP for adolescent girls and young women and men in sub-Saharan Africa: a scoping review

Trisha Ramraj, Witness Chirinda, Kim Jonas, Darshini Govindasamy, Ngcwalisa Jama, Tracy McClinton Appollis, Babalwa Zani, Ferdinand C Mukumbang, Wisdom Basera, Mbuzeleni Hlongwa, Eunice B Turawa, Catherine Mathews, Edward Nicol

BMJ Open. 2023; 13(3): e061503. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-061503

PMCID:: PMC10069497

Abstract Article PDF–732K

Piloting an online telecoaching community-based exercise intervention with adults living with HIV: protocol for a mixed-methods implementation science study

Kelly K O'Brien, Francisco Ibáñez-Carrasco, Soo Chan Carusone, Ahmed M Bayoumi, Ada Tang, Kiera McDuff, Tizneem Jiancaro, George Da Silva, Brittany Torres, Mona R Loutfy, Shaz Islam, Joanne Lindsay, Colleen Price, Mehdi Zobeiry, Zoran Pandovski, Ivan Illic, Puja Ahluwalia, Darren A Brown, Lisa Avery, Patricia Solomon

BMJ Open. 2023; 13(3): e067703. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-067703

PMCID:: PMC10069544

Abstract Article PDF–1.9M

Cohort profile: InfCareHIV, a prospective registry-based cohort study of people with diagnosed HIV in Sweden

Christina Carlander, Johanna Brännström, Fredrik Månsson, Olof Elvstam, Pernilla Albinsson, Simon Blom, Lena Mattsson, Sanne Hovmöller, Hans Norrgren, Åsa Mellgren, Veronica Svedhem, Magnus Gisslén, Anders Sönnerborg

BMJ Open. 2023; 13(3): e069688. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-069688

PMCID:: PMC10030896

Abstract Article PDF–517K

Health and medical professionals’ antenatal HIV testing practices and perceived barriers to routine testing in Tasmania, Australia: a qualitative study

Jennifer Elizabeth Ayton, Grace Bennett-Daly, Amy Nguyen, Louise Owen

BMJ Open. 2023; 13(3): e069819. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-069819

PMCID:: PMC9990605

Abstract Article PDF–496K

Categorising implementation determinants and strategies within the US HIV implementation literature: a systematic review protocol

James Lorenz Merle, Dennis Li, Brennan Keiser, Alithia Zamantakis, Artur Queiroz, Carlos G Gallo, Juan A Villamar, Virginia McKay, Juan Pablo Zapata, Brian Mustanski, Nanette Benbow, Justin D Smith

BMJ Open. 2023; 13(3): e070216. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-070216

PMCID:: PMC10030793

Abstract Article PDF–370K

Haematology (Incl Blood Transfusion)

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design

Rachael F Grace, Eduard J van Beers, Joan-Lluis Vives Corrons, Bertil Glader, Andreas Glenthøj, Hitoshi Kanno, Kevin H M Kuo, Carl Lander, D Mark Layton, Dagmar Pospíŝilová, Vip Viprakasit, Junlong Li, Yan Yan, Audra N Boscoe, Chris Bowden, Paola Bianchi

BMJ Open. 2023; 13(3): e063605. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-063605

PMCID:: PMC10040033

Abstract Article PDF–483K

Psychometric evaluation of the NTDT-PRO questionnaire for assessing symptoms in patients with non-transfusion-dependent beta-thalassaemia

Ali T Taher, Khaled M Musallam, Vip Viprakasit, Antonis Kattamis, Jennifer Lord-Bessen, Aylin Yucel, Shien Guo, Christopher Pelligra, Alan L Shields, Jeevan K Shetty, Dimana Miteva, Luciana Moro Bueno, Maria Domenica Cappellini

BMJ Open. 2023; 13(3): e066683. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-066683

PMCID:: PMC10040027

Abstract Article PDF–438K

Health Economics

Potential impact on cost-effectiveness estimates of using immature survival data: a case study based on transcatheter edge-to-edge repair (TEER) used for patients with severe mitral regurgitation at high surgical risk

Martin Connock, Peter Auguste, Aude Capelle, Anna-Maria Hénaine, Jean-François Obadia, Xavier Armoiry

BMJ Open. 2023; 13(3): e060423. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2021-060423

PMCID:: PMC10016287

Abstract Article PDF–689K

Budget impact analysis of a home-based colorectal cancer screening programme in Malaysia

Tran Thu Ngan, Kogila Ramanathan, Muhamad Raziq Bin Mohd Saleh, Desiree Schliemann, Nor Saleha Binti Ibrahim Tamin, Tin Tin Su, Michael Donnelly, Ciaran O'Neill

BMJ Open. 2023; 13(3): e066925. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-066925

PMCID:: PMC10032398

Abstract Article PDF–1.3M

Methodology of economic evaluations in spine surgery: a systematic review and qualitative assessment

Ruud Droeghaag, Valérie N E Schuermans, Sem M M Hermans, Anouk Y J M Smeets, Inge J M H Caelers, Mickaël Hiligsmann, Silvia Evers, Wouter L W van Hemert, Henk van Santbrink

BMJ Open. 2023; 13(3): e067871. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-067871

PMCID:: PMC10040072

Abstract Article PDF–602K

Cost-effectiveness of running a paediatric oncology unit in Ethiopia

Mizan Kiros, Solomon Tessema Memirie, Mieraf Taddesse Taddesse Tolla, Michael Tekle Palm, Daniel Hailu, Ole F Norheim

BMJ Open. 2023; 13(3): e068210. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068210

PMCID:: PMC10016307

Abstract Article PDF–1.0M

Prophylaxis for Pneumocystis carinii pneumonia in non-Hodgkin’s lymphoma undergoing R-CHOP21 in China: a meta-analysis and cost-effectiveness analysis

Xiaojia Huang, Xiaoting Huang, Shen Lin, Shaohong Luo, Liangliang Dong, Dong Lin, Yaping Huang, Chen Xie, Dongni Nian, Xiongwei Xu, Xiuhua Weng

BMJ Open. 2023; 13(3): e068943. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-068943

PMCID:: PMC10069585

Abstract Article PDF–874K

Estimating time and transportation costs associated with lung cancer screening and diagnostic lung procedures in Taiwan: a cross-sectional survey in a medical centre

Chi-Hao Wu, Li-Jung Elizabeth Ku, Chien-Yu Lin, Ta-Jung Chung, Hui-Ju Liu, Ting-Hsing Chao, Szu-Chun Yang

BMJ Open. 2023; 13(3): e070647. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-070647

PMCID:: PMC10008383

Abstract Article PDF–270K

Health Informatics

Health information use and associated factors among healthcare professionals in Ilu Aba Bor zone, Oromia region, Ethiopia: an institution-based cross-sectional study

Dessalegn Negera, Asrat Zewdie, Abeza Mitiku Kera, Gutama Haile Degefa

BMJ Open. 2023; 13(3): e067540. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-067540

PMCID:: PMC10016269

Abstract Article PDF–412K

Health Policy

Eliciting primary healthcare physicians’ preferences for job characteristics in rural China: a discrete choice experiment

Meiling Bao, Cunrui Huang, Lei Wang, Gang Yan, Gang Chen

BMJ Open. 2023; 13(3): e056741. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2021-056741

PMCID:: PMC10030470

Abstract Article PDF–435K

Comparing pharmaceutical company payments in the four UK countries: a cross-sectional and social network analysis

Emily Rickard, Emma Carmel, Piotr Ozieranski

BMJ Open. 2023; 13(3): e061591. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-061591

PMCID:: PMC10069501

Abstract Article PDF–677K

Evaluating equity dimensions of infant and child vitamin A supplementation programmes using Demographic and Health Surveys from 49 countries

Kevin Tang, Hallie Eilerts, Annette Imohe, Katherine P Adams, Fanny Sandalinas, Grainne Moloney, Edward Joy, Andreas Hasman

BMJ Open. 2023; 13(3): e062387. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-062387

PMCID:: PMC10016247

Abstract Article PDF–2.3M

Effect of general health checks on the treatment of chronic diseases: accounting for self-selection in the retrospective cohort study using Korea National Health Insurance data

Sungwook Yoon, Duk Bin Jun, Sungho Park

BMJ Open. 2023; 13(3): e064425. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-064425

PMCID:: PMC10030471

Abstract Article PDF–399K

National cross-sectional study of the sociodemographic characteristics of Aotearoa New Zealand’s regulated health workforce pre-registration students: a mirror on society?

Peter Crampton, Warwick Bagg, Zoe Bristowe, Paul Brunton, Elana Curtis, Chris Hendry, Bridget Kool, Damian Scarf, Susan Shaw, Collin Tukuitonga, Jonathan Williman, Denise Wilson

BMJ Open. 2023; 13(3): e065380. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-065380

PMCID:: PMC10016278

Abstract Article PDF–1.4M

Instruments for assessing quality policies and strategies in health systems: a scoping review protocol

Márcia Cunha da Silva Pellense, Zenewton André da Silva Gama

BMJ Open. 2023; 13(3): e065846. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-065846

PMCID:: PMC10030568

Abstract Article PDF–275K

Effects of verbal violence on job satisfaction, work engagement and the mediating role of emotional exhaustion among healthcare workers: a cross-sectional survey conducted in Chinese tertiary public hospitals

Yiyin Cao, Lei Gao, Lihua Fan, Zhong Zhang, Xinyan Liu, Mingli Jiao, Ye Li, Shu'e Zhang

BMJ Open. 2023; 13(3): e065918. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-065918

PMCID:: PMC10008349

Abstract Article PDF–599K

Identifying strategic human resource management ability in the clinical departments of public hospitals in China: a modified Delphi study

Xingmiao Feng, Ying Qu, Kaijie Sun, Tao Luo, Kai Meng

BMJ Open. 2023; 13(3): e066599. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066599

PMCID:: PMC10030578

Abstract Article PDF–619K

How can the priorities of older, frail patients and their carers be used to inform policy and practice at the end of life? Insights from qualitative research across multiple settings

Rhiannon Jane Barker, Patricia Wilson, Claire Butler

BMJ Open. 2023; 13(3): e068751. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068751

PMCID:: PMC10032383

Abstract Article PDF–268K

Health Services Research

Risk factors for incident falls in Singaporean community-dwelling adult men and women: a prospective cohort study

Wan Fen Yip, Lixia Ge, Bee Hoon Heng, Woan Shin Tan

BMJ Open. 2023; 13(3): e057931. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2021-057931

PMCID:: PMC9990598

Abstract Article PDF–350K

A Systematic review protocol on workplace equality and inclusion practices in the healthcare sector

Siobhan Ni Luasa, Nuala Ryan, Raymond Lynch

BMJ Open. 2023; 13(3): e064939. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-064939

PMCID:: PMC10030559

Abstract Article PDF–287K

Improving rural and regional access to long-acting reversible contraception and medical abortion through nurse-led models of care, task-sharing and telehealth (ORIENT): a protocol for a stepped-wedge pragmatic cluster-randomised controlled trial in Australian general practice

Danielle Mazza, Mridula Shankar, Jessica R Botfield, Jessica E Moulton, Samantha Paubrey Chakraborty, Kirsten Black, Jane Tomnay, Deborah Bateson, Jody Church, Tracey-Lea Laba, Jessica Kasza, Wendy V Norman

BMJ Open. 2023; 13(3): e065137. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-065137

PMCID:: PMC10040016

Abstract Article PDF–2.0M

Meaning of Family Reported Outcome Measure (FROM-16) severity score bands: a cross-sectional online study in the UK

Rubina Shah, Andrew Y Finlay, Sam M Salek, Stuart J Nixon, Kennedy Otwombe, Faraz M Ali, John R Ingram

BMJ Open. 2023; 13(3): e066168. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-066168

PMCID:: PMC10040025

Abstract Article PDF–790K

Qualitative study of the roles of midwives in the provision of sexual and reproductive healthcare services in the Somaliland health system

Rahel Tesfa Maregn, Kirsty Bourret, Jama Ali Egal, Amina Esse, Cristina Mattison, Marie Klingberg-Allvin

BMJ Open. 2023; 13(3): e067315. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067315

PMCID:: PMC10030797

Abstract Article PDF–263K

Protocol for the development of a core outcome set for studies on centralisation of healthcare services

Stefanie Pfisterer-Heise, Julia Scharfe, Charlotte Mareike Kugler, Eni Shehu, Tobias Wolf, Tim Mathes, Dawid Pieper

BMJ Open. 2023; 13(3): e068138. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068138

PMCID:: PMC10032414

Abstract Article PDF–322K

Retrospective cross-sectional study examining the association between loneliness and unmet healthcare needs among middle-aged and older adults using the Canadian Longitudinal Study of Aging (CLSA)

Stephanie Chamberlain, Rachel D Savage, Susan E Bronskill, Lauren E Griffith, Paula Rochon, Jesse Batara, Andrea Gruneir

BMJ Open. 2023; 13(3): e068769. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068769

PMCID:: PMC10016309

Abstract Article PDF–440K

How does discharge against medical advice affect risk of mortality and unplanned readmission? A retrospective cohort study set in a large UK medical admissions unit

Anand Alagappan, Thomas J G Chambers, Erik Brown, Sheila M Grecian, Khalida Ann Lockman

BMJ Open. 2023; 13(3): e068801. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-068801

PMCID:: PMC10069606

Abstract Article PDF–394K

Effectiveness of brief psychosocial support for patients with cancer and their relatives: a quasi-experimental evaluation of cancer counselling centres

Solveigh Paola Lingens, Georgia Schilling, Holger Schulz, Christiane Bleich

BMJ Open. 2023; 13(3): e068963. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068963

PMCID:: PMC10069588

Abstract Article PDF–381K

Application of complexity theory in health and social care research: a scoping review

Áine Carroll, Claire Collins, Jane McKenzie, Diarmuid Stokes, Andrew Darley

BMJ Open. 2023; 13(3): e069180. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-069180

PMCID:: PMC10030763

Abstract Article PDF–721K

Characteristics of immunisation support programmes in Canada: a scoping review and environmental scan

Katherine Jennifer Kelly, Kim Mears, Sarah Doak, Gail Macartney, Margie Burns, Janet Loo, Laurie Michael, Bei Bei Jia, William Montelpare

BMJ Open. 2023; 13(3): e070400. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-070400

PMCID:: PMC10069581

Abstract Article PDF–460K

Evaluation of the implementation of single points of access for unattached patients in primary care and their effects: a study protocol

Mylaine Breton, Catherine Lamoureux-Lamarche, Véronique Deslauriers, Maude Laberge, Josée Arsenault, Isabelle Gaboury, Marie Beauséjour, Marie-Pascale Pomey, Aude Motulsky, Annie Talbot, Annie St-Yves, Mélanie Ann Smithman, Nadia Deville-Stoetzel, Carine Sauvé, Sabina Abou Malham

BMJ Open. 2023; 13(3): e070956. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-070956

PMCID:: PMC9990645

Abstract Article PDF–1.3M

Infectious Diseases

Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis

Yuki Furukawa, Yan Luo, Satoshi Funada, Akira Onishi, Edoardo Ostinelli, Tasnim Hamza, Toshi A Furukawa, Yuki Kataoka

BMJ Open. 2023; 13(3): e061023. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-061023

PMCID:: PMC10040075

Abstract Article PDF–1.3M

Healthcare workers’ level of adherence to infection prevention and control and its impact on puerperal and neonatal sepsis among delivering women and neonates in Central Tanzania: a protocol for a prospective cohort study

Laura Edward Marandu, Golden Mwakibo Masika

BMJ Open. 2023; 13(3): e066701. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066701

PMCID:: PMC10016239

Abstract Article PDF–443K

Impact of testosterone use on the vaginal microbiota of transgender men, including susceptibility to bacterial vaginosis: study protocol for a prospective, observational study

Christina A Muzny, Olivia T Van Gerwen, Julia A Schroeder, Emma Sophia Kay-Duncan, Krishmita Siwakoti, Kristal J Aaron, Isaac C Eastlund, Keonte J Graves, Jacob H Elnaggar, Ashutosh Tamhane, Dustin Long, Nicholas Van Wagoner, Evelyn Toh, Christopher M Taylor

BMJ Open. 2023; 13(3): e073068. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2023-073068

PMCID:: PMC10069580

Abstract Article PDF–661K

Intensive Care

Time spent on documenting quality indicator data and associations between the perceived burden of documenting these data and joy in work among professionals in intensive care units in the Netherlands: a multicentre cross-sectional survey

Gijs Hesselink, Rutger Verhage, Oscar Hoiting, Eva Verweij, Inge Janssen, Brigitte Westerhof, Gilian Ambaum, Iwan C C van der Horst, Paul de Jong, Nynke Postma, Johannes G van der Hoeven, Marieke Zegers

BMJ Open. 2023; 13(3): e062939. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-062939

PMCID:: PMC9990602

Abstract Article PDF–423K

Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study

Son Ngoc Do, Co Xuan Dao, Tuan Anh Nguyen, My Ha Nguyen, Dung Thi Pham, Nga Thi Nguyen, Dai Quang Huynh, Quoc Trong Ai Hoang, Cuong Van Bui, Thang Dinh Vu, Ha Nhat Bui, Hung Tan Nguyen, Hai Bui Hoang, Thuy Thi Phuong Le, Lien Thi Bao Nguyen, Phuoc Thien Duong, Tuan Dang Nguyen, Vuong Hung Le, Giang Thi Tra Pham, Giang Thi Huong Bui, Tam Van Bui, Thao Thi Ngoc Pham, Chi Van Nguyen, Anh Dat Nguyen, Jason Phua, Andrew Li, Chinh Quoc Luong

BMJ Open. 2023; 13(3): e064870. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-064870

PMCID:: PMC10016261

Abstract Article PDF–1.1M

Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial

Jérôme Fleuriet, Nicholas Heming, Ferhat Meziani, Jean Reignier, Pierre-Louis Declerq, Emmanuelle Mercier, Grégoire Muller, Gwenhaël Colin, Xavier Monnet, Adrien Robine, Shidasp Siami, Fabrice Uhel, Jean-Pierre Quenot, Gaetan Plantefeve, Julio Badie, Francis Schneider, Charles Cerf, Gilles Troché, Mehran Monchi, Jean-Paul Mira, Bruno Francois, Grimaldi Lamiae, Sylvie Chevret, Djillali Annane, RECORDS consortium, RECORDS consortium

BMJ Open. 2023; 13(3): e066496. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066496

PMCID:: PMC10008229

Abstract Article PDF–860K

Protocol and statistical analysis plan for the Antibiotic Choice On ReNal outcomes (ACORN) randomised clinical trial

Edward Tang Qian, Jonathan D Casey, Adam Wright, Li Wang, Justin Siemann, Mary Lynn Dear, Joanna Stollings, Bradley Daniel Lloyd, Kevin Seitz, George Nelson, Patty Wright, Edward D Siew, Bradley Dennis, Jesse Wrenn, Jonathan Andereck, Wesley H Self, Matthew W Semler, Todd W Rice, Vanderbilt Learning Healthcare System Platform Investigators

BMJ Open. 2023; 13(3): e066995. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066995

PMCID:: PMC10008324

Abstract Article PDF–786K

Development and validation of a nomogram for predicting in-hospital mortality of elderly patients with persistent sepsis-associated acute kidney injury in intensive care units: a retrospective cohort study using the MIMIC-IV database

Wei Jiang, Chuanqing Zhang, Jiangquan Yu, Jun Shao, Ruiqiang Zheng

BMJ Open. 2023; 13(3): e069824. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-069824

PMCID:: PMC10069590

Abstract Article PDF–562K

Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Thilo von Groote, Melanie Meersch, Stefano Romagnoli, Marlies Ostermann, Javier Ripollés-Melchor, Antoine Guillaume Schneider, Wim Vandenberghe, Céline Monard, Silvia De Rosa, Lucia Cattin, Tim Rahmel, Michael Adamzik, Diego Parise, Angel Candela-Toha, Jan Gerrit Haaker, Ulrich Göbel, Alice Bernard, Nuttha Lumlertgul, Paula Fernández-Valdes-Bango, Irene Romero Bhathal, A Suarez-de-la-Rica, Jan Larmann, Gianluca Villa, Savino Spadaro, Hinnerk Wulf, Christian Arndt, Christian Putensen, Raquel García-Álvarez, Timo Brandenburger, Antonio Siniscalchi, Richard Ellerkmann, Florian Espeter, Christian Porschen, Mahan Sadjadi, Khaschayar Saadat-Gilani, Raphael Weiss, Joachim Gerss, John Kellum, Alexander Zarbock, for the BigpAK-2 Investigators

BMJ Open. 2023; 13(3): e070240. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-070240

PMCID:: PMC10069589

Abstract Article PDF–933K

Legal and Forensic Medicine

Medical evidence assisting non-fatal strangulation prosecution: a scoping review

Leah S Sharman, Robin Fitzgerald, Heather Douglas

BMJ Open. 2023; 13(3): e072077. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2023-072077

PMCID:: PMC10077461

Abstract Article PDF–634K

Medical Education and Training

Entrustable professional activities in postgraduate general surgery training: a scoping review protocol

Daniel Nel, Eduard Jonas, Vanessa Burch, Amy Nel, Lydia Cairncross, Adnan Alseidi, Brian George, Olle ten Cate

BMJ Open. 2023; 13(3): e067322. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067322

PMCID:: PMC10030674

Abstract Article PDF–291K

Medical Management

Lipid management in ischaemic stroke or transient ischaemic attack in China: result from China National Stroke Registry III

Yu-Yuan Xu, Wei-Qi Chen, Meng-Xing Wang, Yue-Song Pan, Zi-Xiao Li, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Hao Li, Yong-Jun Wang, Xia Meng, the CNSR-III Investigators

BMJ Open. 2023; 13(3): e069465. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-069465

PMCID:: PMC10008417

Abstract Article PDF–862K

Medical Publishing and Peer Review

SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol

Aude Espinasse, Olga Solovyeva, Munyaradzi Dimairo, Christopher Weir, Thomas Jaki, Adrian Mander, Andrew Kightley, Jeffry Evans, Shing Lee, Alun Bedding, Sally Hopewell, Khadija Rantell, Rong Liu, An-Wen Chan, Johann De Bono, Christina Yap

BMJ Open. 2023; 13(3): e068173. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068173

PMCID:: PMC10069529

Abstract Article PDF–590K

Mental Health

Antidepressant Advisor (ADeSS): a decision support system for antidepressant treatment for depression in UK primary care – a feasibility study

Phillippa Harrison, Ewan Carr, Kimberley Goldsmith, Allan Young, Mark Ashworth, Diede Fennema, Suqian Duan, Barbara M Barrett, Roland Zahn

BMJ Open. 2023; 13(3): e060516. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2021-060516

PMCID:: PMC9990646

Abstract Article PDF–1.2M

Lifelong mental health service use among 15–22 years old offenders: a document-based, mixed-methods descriptive study

Eeva Huikko, Terhi Aalto-Setälä, Päivi Santalahti, Riikka Lämsä, Aulikki Ahlgrén-Rimpiläinen

BMJ Open. 2023; 13(3): e065593. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-065593

PMCID:: PMC10030486

Abstract Article PDF–872K

Expectation focused and frequency enhanced cognitive behavioural therapy for patients with major depression (EFFECT): a study protocol of a randomised active-control trial

Anne-Catherine Isabelle Ewen, Gaby Bleichhardt, Winfried Rief, Pia Von Blanckenburg, Katrin Wambach, Marcel Wilhelm

BMJ Open. 2023; 13(3): e065946. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-065946

PMCID:: PMC10040046

Abstract Article PDF–553K

Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study

Luca Magnani, Luca Carmisciano, Felice dell’Orletta, Ornella Bettinardi, Silvia Chiesa, Massimiliano Imbesi, Giuliano Limonta, Elisa Montagna, Ilaria Turone, Dario Martinasso, Andrea Aguglia, Gianluca Serafini, Mario Amore, Andrea Amerio, Alessandra Costanza, Francesca Sibilla, Pietro Calcagno, Sara Patti, Gabriella Molino, Andrea Escelsior, Alice Trabucco, Lisa Marzano, Dominique Brunato, Andrea Amelio Ravelli, Marco Cappucciati, Roberta Fiocchi, Gisella Guerzoni, Davide Maravita, Fabio Macchetti, Elisa Mori, Chiara Anna Paglia, Federica Roscigno, Antonio Saginario, LNG-PSY Study Investigators

BMJ Open. 2023; 13(3): e066642. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-066642

PMCID:: PMC10040055

Abstract Article PDF–418K

Efficacy of a digital mental health intervention embedded in routine care compared with treatment as usual in adolescents and young adults with moderate depressive symptoms: protocol for randomised controlled trial

Eva Szigethy, David Wolfson, Keneisha Sinclair-McBride, Kelly Williams, Grace Jhe, Erica H Lee, Mario Bialostozky, Meredith Wallace, Sonika Bhatnagar, DR Demaso, Donald M Yealy, Kathryn Hollenbach

BMJ Open. 2023; 13(3): e067141. Published online 2023 Mar 31. doi: 10.1136/bmjopen-2022-067141

PMCID:: PMC10069502

Abstract Article PDF–861K

Use of digital technologies by users of psychiatric inpatient services in Berlin, Germany: a cross-sectional patient survey

Derin Marbin, Stefan Gutwinski, Sonia Lech, Daniel Fürstenau, Linda Kokwaro, Helena Krüger, Daniel Schindel, Stefanie Schreiter

BMJ Open. 2023; 13(3): e067311. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-067311

PMCID:: PMC10032388

Abstract Article PDF–422K

Modified cue exposure for adolescents with binge eating behaviour: study protocol of a randomised pilot trial called EXI_(ea)T

Hanna Preuss-van Viersen, Inken Kirschbaum-Lesch, Jasmina Eskic, Sophie Lukes, Jana Pydd, Laura Derks, Florian Hammerle, Tanja Legenbauer

BMJ Open. 2023; 13(3): e067626. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-067626

PMCID:: PMC10039999

Abstract Article PDF–509K

Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

Éimear M Foley, Sian Lowri Griffiths, Alexander Murray, Jack Rogers, Fabiana Corsi-Zuelli, Hannah Hickinbotham, Ella Warwick, Martin Wilson, Muzaffer Kaser, Graham K Murray, Bill Deakin, Deepak Jadon, John Suckling, Nicholas M Barnes, Rachel Upthegrove, Golam M Khandaker, for the PIMS Collaboration

BMJ Open. 2023; 13(3): e067944. Published online 2023 Mar 24. doi: 10.1136/bmjopen-2022-067944

PMCID:: PMC10040013

Abstract Article PDF–576K

Designing a library of lived experience for mental health (LoLEM): protocol for integrating a realist synthesis and experience based codesign approach

Fiona Lobban, Paul Marshall, John Barbrook, Grace Collins, Sheena Foster, Zoe Glossop, Clare Inkster, Paul Jebb, Rose Johnston, Hameed Khan, Christopher Lodge, Karen Machin, Erin Michalak, Sarah Powell, Jo Rycroft-Malone, Mike Slade, Lesley Whittaker, Steven H Jones

BMJ Open. 2023; 13(3): e068548. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-068548

PMCID:: PMC10008385

Abstract Article PDF–605K

Effectiveness of a targeted brief intervention for recent suicide attempt survivors: a randomised controlled trial protocol

Anthony Pisani, Kenneth Connor, Kimberly Van Orden, Neil Jordan, Sara Landes, Geoffrey Curran, Michael McDermott, Ashkan Ertefaie, Caroline Kelberman, Seethalakshmi Ramanathan, Jay Carruthers, Kristina Mossgraber, David Goldston

BMJ Open. 2023; 13(3): e070105. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-070105

PMCID:: PMC9990685

Abstract Article PDF–552K

Codesign of a digital health tool for suicide prevention: protocol for a scoping review

Dianne Wepa, Martin Neal, Waseem Abo-Gazala, Sally Cusworth, Jae Hargan, Manoj Mistry, Jimmy Vaughan, Stephen Giles, Mehnaz Khan, Lucy Power, Expert by Experience Group

BMJ Open. 2023; 13(3): e070329. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-070329

PMCID:: PMC10008351

Abstract Article PDF–226K

Examining the acceptability of actigraphic devices in children using qualitative and quantitative approaches: protocol for a systematic review and meta-analysis

Anna Charlotte Morris, Laurence Telesia, Alice Wickersham, Sophie Epstein, Faith Matcham, Edmund Sonuga-Barke, Johnny Downs

BMJ Open. 2023; 13(3): e070597. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-070597

PMCID:: PMC9980313

Abstract Article PDF–370K

Cohort profile: Impact of Maternal and Paternal Mental Health – Assessing Concurrent Depression, Anxiety and Comorbidity in the Canadian Family (IMPACT study)

Cindy-Lee Dennis, Simone Vigod, Sophie Grigoriadis, Hillary Brown, Sarah Brennenstuhl, Justine Dol, Mark Wade, Kobra Falah-Hassani, Rahman Shiri, Flavia Marini

BMJ Open. 2023; 13(3): e071691. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2023-071691

PMCID:: PMC10008457

Abstract Article PDF–627K

Neurology

Qualitative study exploring heterogeneity in caregiving experiences post-stroke in Singapore

Shilpa Tyagi, Nan Luo, Chuen Seng Tan, Kelvin Bryan Tan, Boon Yeow Tan, Edward Menon, N Venketasubramanian, Wei Chin Loh, Shu Hui Fan, Kenneth Lam Thuan Yang, Audrey Swee Ling Chan, Aysha Farwin, Zunairah Binti Lukman, Gerald Choon-Huat Koh

BMJ Open. 2023; 13(3): e055988. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2021-055988

PMCID:: PMC10030476

Abstract Article PDF–595K

Targeting patient recovery priorities in degenerative cervical myelopathy: design and rationale for the RECEDE-Myelopathy trial—study protocol

Benjamin Davies, Oliver D Mowforth, Stefan Yordanov, Daniel Alvarez-Berdugo, Simon Bond, Marianna Nodale, Paula Kareclas, Lynne Whitehead, Jon Bishop, Siddharthan Chandran, Sarah Lamb, Mark Bacon, Marios C Papadopoulos, Michelle Starkey, Iwan Sadler, Lara Smith, Sukhvinder Kalsi-Ryan, Adrian Carpenter, Rikin A Trivedi, Martin Wilby, David Choi, Ian B Wilkinson, Michael G Fehlings, Peter John Hutchinson, Mark R N Kotter

BMJ Open. 2023; 13(3): e061294. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-061294

PMCID:: PMC10008337

Abstract Article PDF–1022K

Diagnostic value of PET with different radiotracers and MRI for recurrent glioma: a Bayesian network meta-analysis

Tian Xiaoxue, Wang Yinzhong, Qi Meng, Xingru Lu, Junqiang Lei

BMJ Open. 2023; 13(3): e062555. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-062555

PMCID:: PMC9990663

Abstract Article PDF–1.1M

In-hospital mortality and risk factors among elderly patients with traumatic brain injury: protocol for a systematic review and meta-analysis

Zixuan Ma, Jiyuan Hui, Chun Yang, Jiyao Jiang, LI Xie, Junfeng Feng

BMJ Open. 2023; 13(3): e065371. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-065371

PMCID:: PMC10030481

Abstract Article PDF–551K

Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy

Nadia Al-Najjar, Lucy Bray, Bernie Carter, Advisory Panel CASTLE, Amber Collingwood, Georgia Cook, Holly Crudgington, Janet Currier, Kristina Charlotte Dietz, Will A S Hardy, Harriet Hiscock, Dyfrig Hughes, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Holly Saron, Catherine Spowart, Lucy Stibbs-Eaton, Catrin Tudur Smith, Victoria Watson, Liam Whittle, Luci Wiggs, Eifiona Wood, Paul Gringras, Deb K Pal

BMJ Open. 2023; 13(3): e065769. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-065769

PMCID:: PMC10008377

Abstract Article PDF–766K

Prevalence of spontaneous recanalisation of complete internal carotid occlusion: protocol for a systematic scoping review

Sarah Y Zhang, Brian Dewar, Robert Fahed, Michel Shamy, Risa Shorr, Dar Dowlatshahi

BMJ Open. 2023; 13(3): e067773. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-067773

PMCID:: PMC10008469

Abstract Article PDF–220K

Effects of integrated action and sensory observation therapy based on mirror neuron and embodied cognition theory on upper limb sensorimotor function in chronic stroke: a study protocol for a randomised controlled trial

Zhiqing Zhou, Xixi Chen, Yuanli Li, Songmei Chen, Sicong Zhang, Yuwei Wu, Xiaolong Shi, Meng Ren, Chunlei Shan

BMJ Open. 2023; 13(3): e069126. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-069126

PMCID:: PMC10008471

Abstract Article PDF–719K

ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 – a longitudinal cohort study

Neil S N Graham, Grace Blissitt, Karl Zimmerman, Daniel Friedland, Marc-Emmanuel Dumas, Emma Coady, Amanda Heslegrave, Henrik Zetterberg, Valentina Escott-Price, Susie Schofield, Nicola T Fear, Christopher Boos, Anthony M J Bull, Paul Cullinan, Alexander Bennett, David J Sharp

BMJ Open. 2023; 13(3): e069243. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-069243

PMCID:: PMC10032415

Abstract Article PDF–515K

Impact of digital technologies on self-efficacy in people with Parkinson’s: a scoping review protocol

Andrew Michael Hall, S Aroori, Camille B Carroll, Edward Meinert, Victoria Allgar

BMJ Open. 2023; 13(3): e069929. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-069929

PMCID:: PMC10039994

Abstract Article PDF–386K

Risk of Aneurysm Rupture (ROAR) study: protocol for a long-term, longitudinal, UK multicentre study of unruptured intracranial aneurysms

Samuel Hall, Jacqueline Birks, Ian Anderson, Andrew Bacon, Paul M Brennan, David Bennett, Emmanuel Chavredakis, Giles Critchley, Graham Dow, Jonathan Downer, James Galea, Patrick Grover, Nihal Gurusinghe, Adel Helmy, Gueorgui Kounin, Nitin Mukerji, Hiren Patel, Jash Patel, Nicholas Ross, Jerome St George, Mario Teo, Christos Michael Tolias, Nikolaos Tzerakis, Christopher Uff, Janneke van Beijum, Kristin Veighey, Edward White, Peter Whitfield, Diederik Oliver Bulters, ROAR Investigators

BMJ Open. 2023; 13(3): e070504. Published online 2023 Mar 16. doi: 10.1136/bmjopen-2022-070504

PMCID:: PMC10030903

Abstract Article PDF–360K

Impact of prestroke physical activity and citalopram treatment on poststroke depressive symptoms: a secondary analysis of data from the TALOS randomised controlled trial in Denmark

Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Rolf Ankerlund Blauenfeldt, Søren Paaske Johnsen, Grethe Andersen, Janne Kaergaard Mortensen

BMJ Open. 2023; 13(3): e070822. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-070822

PMCID:: PMC10069592

Abstract Article PDF–793K

Understanding living with tracheostomy ventilation for motor neuron disease and the implications for quality of life: a qualitative study protocol

Eleanor Wilson, Nicola Turner, Christina Faull, Jonathan Palmer, Martin R Turner, Scott Davidson

BMJ Open. 2023; 13(3): e071624. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2023-071624

PMCID:: PMC10016280

Abstract Article PDF–313K

Nursing

Effect of a family-involvement combined aerobic and resistance exercise protocol on cancer-related fatigue in patients with breast cancer during postoperative chemotherapy: study protocol for a quasi-randomised controlled trial

Chuhan Huang, Yingjie Cai, Yufei Guo, Jingjing Jia, Tieying Shi

BMJ Open. 2023; 13(3): e064850. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-064850

PMCID:: PMC10069511

Abstract Article PDF–463K

Preventive interventions for paternal perinatal depression: a scoping review protocol

Hiroko Iwata, Emi Mori, Kunie Maehara, Kayoko Kimura, Fusae Toyama, Asana Kakehashi, Marika Seki, Sayaka Abe, Mai Kosaka

BMJ Open. 2023; 13(3): e065126. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-065126

PMCID:: PMC10008156

Abstract Article PDF–250K

Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China

Chunfang Yu, Tingting Cai, Tingting Zhou, Ning Zeng, Xin Liang, Guihua Pan, Wei Ouyang, Changrong Yuan

BMJ Open. 2023; 13(3): e066467. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066467

PMCID:: PMC10016277

Abstract Article PDF–286K

Differences in humble leadership and team performance in nursing: an online cross-sectional study

Majd T Mrayyan

BMJ Open. 2023; 13(3): e066920. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066920

PMCID:: PMC10008339

Abstract Article PDF–312K

Prevalence of and factors influencing depression and anxiety among Chinese adolescents: a protocol for a systematic review

Keyi Zhou, Jiarui Chen, Chongmei Huang, Siyuan Tang

BMJ Open. 2023; 13(3): e068119. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068119

PMCID:: PMC10040053

Abstract Article PDF–292K

Nurses’ practice of peripherally inserted central catheter maintenance and its influencing factors in Guizhou province, China: a cross-sectional study

Li Hu, Yaling Li, Hong Li, Wenjing Ling, Chaoting Zheng, Mingfei Ran, Binbin Xu

BMJ Open. 2023; 13(3): e068656. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-068656

PMCID:: PMC10069491

Abstract Article PDF–368K

Fundamental nursing care focusing on older people’s needs and continuity of long-term care: a scoping review protocol

Ole Martin Nordaunet, Edith Roth Gjevjon, Cecilia Olsson, Hanne Aagaard, Gunilla Borglin

BMJ Open. 2023; 13(3): e069798. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069798

PMCID:: PMC10069605

Abstract Article PDF–410K

Gender-affirming care in undergraduate nursing education: a scoping review protocol

Jess Crawford, Annette S H Schultz, Janice Linton, Marnie Kramer, Janice Ristock

BMJ Open. 2023; 13(3): e070576. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-070576

PMCID:: PMC10016310

Abstract Article PDF–271K

Reporting quality of abstracts from randomised controlled trials published in leading critical care nursing journals: a methodological quality review

Michele Villa, Massimo Le Pera, Tiziano Cassina, Michela Bottega

BMJ Open. 2023; 13(3): e070639. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-070639

PMCID:: PMC10030738

Abstract Article PDF–954K

Nutrition and Metabolism

Association between early life exposure to the great famine and possible sarcopenia in older Chinese adults: a national cross-sectional study

Ting Wu, Xiaojin Yan, Yunfei Liu, Ning Ma, Jiajia Dang, Panliang Zhong, Di Shi, Shan Cai, Hao Cheng, Yi Song, Patrick W C Lau

BMJ Open. 2023; 13(3): e065240. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-065240

PMCID:: PMC9980362

Abstract Article PDF–577K

Effect of date seed (Phoenix dactylifera) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

Mehdi Mohammadi Zadeh, Parvin Dehghan, Zahra Eslami

BMJ Open. 2023; 13(3): e066013. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-066013

PMCID:: PMC10030472

Abstract Article PDF–518K

Rectus abdominis and rectus femoris muscle thickness in determining nutritional risk in critically ill patients: a prospective cohort study in Turkey

Canan Gürsoy, Aslı Alkan, Emine Kaya Çubuk, Efsane Karcı, Hüseyin Oğuz Yılmaz, Tümay Çakır

BMJ Open. 2023; 13(3): e071796. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2023-071796

PMCID:: PMC10069567

Abstract Article PDF–811K

Obstetrics and Gynaecology

Healthcare providers’ perceptions and expectations of video-assisted debriefing of real-life obstetrical emergencies: a qualitative study from Denmark

Lena Have Rosvig, Stina Lou, Lone Hvidman, Tanja Manser, Niels Uldbjerg, Ole Kierkegaard, Lise Brogaard

BMJ Open. 2023; 13(3): e062950. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-062950

PMCID:: PMC10016258

Abstract Article PDF–852K

Ambient air pollutants in the first trimester of pregnancy and birth defects: an observational study

Yao Cheng, Jieyun Yin, Lijun Yang, Man Xu, Xinfeng Lu, Wenting Huang, Guohong Dai, Guoqiang Sun

BMJ Open. 2023; 13(3): e063712. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-063712

PMCID:: PMC10040071

Abstract Article PDF–295K

Differential effects of diet and physical activity interventions in pregnancy to prevent gestational diabetes mellitus and reduce gestational weight gain by level of maternal adiposity: a protocol for an individual patient data (IPD) meta-analysis of randomised controlled trials

Anna Boath, Luke Vale, Louise Hayes, John Allotey, Nicola Heslehurst

BMJ Open. 2023; 13(3): e065335. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-065335

PMCID:: PMC10030495

Abstract Article PDF–307K

Application of multilevel linear spline models for analysis of growth trajectories in a cohort with repeat antenatal and postnatal measures of growth: a prospective cohort study

Linda M O'Keeffe, Cara A Yelverton, Helena C Bartels, Kate N O'Neill, Ciara McDonnell, Fionnuala M McAuliffe

BMJ Open. 2023; 13(3): e065701. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-065701

PMCID:: PMC10069489

Abstract Article PDF–1.0M

Impact of maternal hepatitis B carrier status on congenital abnormalities: a systematic review and meta-analysis

Shiyao Huang, Jing Wang, Yiquan Xiong, Chunrong Liu, Yana Qi, Kang Zou, Jing Tan, Xin Sun

BMJ Open. 2023; 13(3): e066017. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-066017

PMCID:: PMC10069551

Abstract Article PDF–1.3M

Prevalence of polypharmacy in pregnancy: a systematic review

Astha Anand, Katherine Phillips, Anuradhaa Subramanian, Siang Ing Lee, Zhaonan Wang, Rebecca McCowan, Utkarsh Agrawal, Adeniyi Frances Fagbamigbe, Catherine Nelson-Piercy, Peter Brocklehurst, Christine Damase-Michel, Maria Loane, Krishnarajah Nirantharakumar, Amaya Azcoaga-Lorenzo, the MuM-PreDiCT Group

BMJ Open. 2023; 13(3): e067585. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-067585

PMCID:: PMC9990613

Abstract Article PDF–1.2M

Utilisation of private general practitioners to provide caesarean deliveries in five rural district public hospitals in South Africa: a mixed-methods study

Tanya Doherty, Geetesh Solanki, Emmanuelle Daviaud, Yvandi Bartmann, Anthony Hawkridge, Sue Fawcus

BMJ Open. 2023; 13(3): e067663. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-067663

PMCID:: PMC9980375

Abstract Article PDF–599K

Women’s experiences of over-the-counter and prescription medication during pregnancy in the UK: findings from survey free-text responses and narrative interviews

Julia Sanders, Rebecca Blaylock, Caitlin Dean, Irene Petersen, Heather Trickey, Clare Murphy

BMJ Open. 2023; 13(3): e067987. Published online 2023 Feb 20. doi: 10.1136/bmjopen-2022-067987

PMCID:: PMC9990671

Abstract Article PDF–287K

Regional practice variation in pelvic organ prolapse surgery in Tuscany, Italy: a retrospective cohort study on administrative health data

Amerigo Ferrari, Andrea Giannini, Chiara Seghieri, Tommaso Simoncini, Milena Vainieri

BMJ Open. 2023; 13(3): e068145. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-068145

PMCID:: PMC10008403

Abstract Article PDF–771K

Associations between plant-based diets, plant foods and botanical supplements with gestational diabetes mellitus: a systematic review protocol

Jessica Ustick, Kaitlin Chakos, Hejingzi Jia, Rosie Hanneke, Brittany DiPiazza, Mary Dawn Koenig, Jun Ma, Bernice Man, Lisa Tussing-Humphreys, Tristesse Catessa Jasmin Burton

BMJ Open. 2023; 13(3): e068829. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068829

PMCID:: PMC10032412

Abstract Article PDF–269K

Use of tranexamic acid (TXA) to reduce preterm birth and other adverse obstetrical outcomes among pregnant individuals with placenta previa: a systematic review protocol

Niève Seguin, Sarah Visintini, Katherine A Muldoon, Mark Walker

BMJ Open. 2023; 13(3): e068892. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-068892

PMCID:: PMC10008160

Abstract Article PDF–362K

Effect of the maternal childbirth experience on a subsequent birth: a retrospective 7-year cohort study of primiparas in Finland

Johanna Maria Joensuu, Hannu Saarijärvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Paulus Torkki, Tomi Mikkola

BMJ Open. 2023; 13(3): e069918. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-069918

PMCID:: PMC10008220

Abstract Article PDF–739K

OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE): study protocol of a multicentre, retrospective cohort study

Mette van de Meent, Dianne G. Kleuskens, Wessel Ganzevoort, Sanne J. Gordijn, Elisabeth M. W. Kooi, Wes Onland, Bas B. van Rijn, Johannes J. Duvekot, René F. Kornelisse, Salwan Al-Nasiry, Reint K. Jellema, H. Marieke Knol, Gwendolyn T. R. Manten, Susanne M. Mulder-de Tollenaer, Jan B. Derks, Floris Groenendaal, Mireille N. Bekker, Ewoud Schuit, A. Titia Lely, Judith Kooiman

BMJ Open. 2023; 13(3): e070729. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-070729

PMCID:: PMC10030622

Abstract Article PDF–974K

Can youth-engaged research facilitate equitable access to contraception in Canada? The qualitative study protocol for the Ask Us project

Sarah Munro, Giuseppina Di Meglio, Aleyah Williams, Skye Pamela Barbic, Stephanie Begun, Amanda Black, Andrea Carson, Michelle Fortin, Kaiya Jacob, Zeba Khan, Ruth Martin-Misener, Salima Meherali, Victoria Paller, Hajar Seiyad, Carol-Anne Vallée, Kate Wahl, Wendy V Norman

BMJ Open. 2023; 13(3): e070904. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-070904

PMCID:: PMC9990688

Abstract Article PDF–1000K

Occupational and Environmental Medicine

Social economic factors and the risk of multiple chemical sensitivity in a Danish population-based cross-sectional study: Danish Study of Functional Disorders (DanFunD)

Anne Ahrendt Bjerregaard, Signe Ulfbeck Schovsbo, Lise K Gormsen, Sine Skovbjerg, Lene Falgaard Eplov, Allan Linneberg, José G Cedeño-Laurent, Torben Jørgensen, Thomas Meinertz Dantoft

BMJ Open. 2023; 13(3): e064618. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-064618

Correction in:: BMJ Open. 2023; 13(4): e064618corr1.

PMCID:: PMC10069487

Abstract Article PDF–359K

MEDEA randomised intervention study protocol in Cyprus, Greece and Israel for mitigation of desert dust health effects in adults with atrial fibrillation

Pinelopi Anagnostopoulou, Panayiotis Kouis, Stefania I Papatheodorou, Nicos Middleton, Ilias Papasavvas, Panayiotis Avraamides, Emmanuel Simantirakis, Ioannis Anastasiou, Victor Novack, Gerasimos Stamatelatos, Efstathios Revvas, Christos Kaniklides, Filippos Tymvios, Chrysanthos Savvides, Petros Koutrakis, Panayiotis K Yiallouros

BMJ Open. 2023; 13(3): e069809. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-069809

PMCID:: PMC10040014

Abstract Article PDF–515K

Oncology

Quality of care in the course of subcutaneous versus intravenous trastuzumab administration in patients with breast cancer: an integrated time–motion study with mixed-methods research

Hsiang-Wen Lin, Chen-Yuan Lin, Tzu-Pei Yeh, Tien-Chao Lin, Wan-Chen Yeh, Lin-Chun Yang, Yu-Chieh Chen, Li-Ying Chiu, Chen-Teng Wu, Chih-Jung Chen, Yu-Fen Chen, Hwei-Chung Wang, Yao-Chung Wu, Liang-Chih Liu

BMJ Open. 2023; 13(3): e059288. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2021-059288

PMCID:: PMC10030473

Abstract Article PDF–1.5M

Protocol for the CoNoR Study: A prospective multi-step study of the potential added benefit of two novel assessment tools in colorectal liver metastases technical resectability decision-making

Kat L Parmar, Derek O'Reilly, Juan Valle, Michael Braun, Lee Malcomson, Robert P Jones, Fady Balaa, Myrddin Rees, Fenella K S Welsh, Rafik Filobbos, Andrew G Renehan

BMJ Open. 2023; 13(3): e059369. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2021-059369

PMCID:: PMC10069542

Abstract Article PDF–991K

Organ-specific immune checkpoint inhibitor treatment in lung cancer: a systematic review and meta-analysis

Shufei Yu, Shuyang Zhang, Haiyan Xu, Guangjian Yang, Fei Xu, Liang Yang, Duo Chen, Guangyu An, Yan Wang

BMJ Open. 2023; 13(3): e059457. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2021-059457

PMCID:: PMC10030562

Abstract Article PDF–3.1M

What do we know about the psychosocial issues associated with cancer during pregnancy? A scoping review and gap analysis

Jenny Harris, Emma Ream, Jo Armes, Faith Gibson, Afrodita Marcu, Catherine Treena Parsons, Ann Robinson, Sherin Varghese, Karen Poole

BMJ Open. 2023; 13(3): e063283. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-063283

PMCID:: PMC9990617

Abstract Article PDF–1.2M

Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort

Andreas Palm, J Theorell-Haglöw, Johan Isakson, Mirjam Ljunggren, Josefin Sundh, Magnus Per Ekström, Ludger Grote

BMJ Open. 2023; 13(3): e064501. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-064501

PMCID:: PMC9990651

Abstract Article PDF–637K

Prognostic value of miR-219-5p in relation to mortality in patients with small cell lung cancer: a retrospective, observational cohort study in China

Xiangmei Wu, Jigang Zhang, Xiaohui Zhang, Mengqi Xiang, Zhihua Xu, Zhijun Cao

BMJ Open. 2023; 13(3): e064700. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-064700

PMCID:: PMC10069522

Abstract Article PDF–882K

Contribution of coping style to the association between illness uncertainty and demoralisation in patients with breast cancer: a cross-sectional mediation analysis

Ran Hao, Meng Zhang, Jinfan Zuo, Yixin Qi, Jie Hu

BMJ Open. 2023; 13(3): e065796. Published online 2023 Mar 16. doi: 10.1136/bmjopen-2022-065796

PMCID:: PMC10030480

Abstract Article PDF–1.4M

Optimising psychological treatment for pain after breast cancer: a factorial design study protocol in Denmark

Cecilie Buskbjerg, Mia Skytte O'Toole, Robert Zachariae, Anders Bonde Jensen, Yoon Frederiksen, Christoffer Johansen, Annika von Heymann, Anne Speckens, Maja Johannsen

BMJ Open. 2023; 13(3): e066505. Published online 2023 Mar 22. doi: 10.1136/bmjopen-2022-066505

PMCID:: PMC10040060

Abstract Article PDF–1006K

Combining chemotherapy and tislelizumab with preoperative split-course hypofraction radiotherapy for locally advanced rectal cancer: study protocol of a prospective, single-arm, phase II trial

Rong Zheng, Bi-Si Wang, Zhihua Li, Pan Chi, Benhua Xu

BMJ Open. 2023; 13(3): e066976. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-066976

PMCID:: PMC10030573

Abstract Article PDF–539K

Treatment burden in survivors of prostate and colorectal cancers: a qualitative interview study

Rosalind Adam, Lisa Duncan, Sara J Maclennan, Louise Locock

BMJ Open. 2023; 13(3): e068997. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-068997

PMCID:: PMC9990667

Abstract Article PDF–695K

Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer (NECI Study): a protocol for a phase II study

Yiqun Fan, Xiaoling Zhu, Chengcai Xu, Caiyou Ding, Jibo Hu, Qiang Hong, Jianwei Wang

BMJ Open. 2023; 13(3): e069401. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-069401

PMCID:: PMC10016271

Abstract Article PDF–524K

Behavioural economic interventions to embed palliative care in community oncology (BE-EPIC): study protocol for the BE-EPIC randomised controlled trial

Ravi B Parikh, Ramy Sedhom, William J Ferrell, Katherine Villarin, Kara Berwanger, Bethann Scarborough, Randall Oyer, Pallavi Kumar, Niharika Ganta, Shanthi Sivendran, Jinbo Chen, Kevin G Volpp, Justin E Bekelman

BMJ Open. 2023; 13(3): e069468. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-069468

PMCID:: PMC10040061

Abstract Article PDF–793K

Effectiveness of a facilitation programme using a mobile application for initiating advance care planning discussions between patients with advanced cancer and healthcare providers: protocol for a randomised controlled trial (J-SUPPORT 2104)

Kyoko Obama, Maiko Fujimori, Masako Okamura, Midori Kadowaki, Taro Ueno, Narikazu Boku, Masanori Mori, Tatsuo Akechi, Takuhiro Yamaguchi, Shunsuke Oyamada, Ayumi Okizaki, Tempei Miyaji, Naomi Sakurai, Yosuke Uchitomi

BMJ Open. 2023; 13(3): e069557. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069557

PMCID:: PMC10069562

Abstract Article PDF–640K

Trends in antineoplastic drug use, cost and prescribing patterns among patients with lung cancer in nine major cities of China, 2016–2020: a retrospective observational study based on inpatient and outpatient hospital data

Jingyuan Shang, Lixin Zhou, Lin Huang, Feng Yang, Yanguo Liu, Chunyan Zhang, Li'an Zu, Rongrong Fan, Xiaohong Zhang, Yi Liu, Yufei Feng

BMJ Open. 2023; 13(3): e069645. Published online 2023 Mar 16. doi: 10.1136/bmjopen-2022-069645

PMCID:: PMC10030656

Abstract Article PDF–1.2M

Impact of COVID-19 pandemic on the diagnosis of patients with skin cancer: a systematic review protocol

Seyed Mostafa Mostafavi Zadeh, Yasaman Rezaei, Ahmadreza Barahimi, Ebrahim Abbasi, Roudabeh Malekzadeh

BMJ Open. 2023; 13(3): e069720. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-069720

PMCID:: PMC10008412

Abstract Article PDF–256K

Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH-mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden

Liv Cathrine Heggebø, Ida Maria Henriksen Borgen, Hillevi Rylander, Cecilie Kiserud, Tonje Haug Nordenmark, Taran Paulsen Hellebust, Morten Egeberg Evensen, Magnus Gustavsson, Christina Ramberg, Mette Sprauten, Henriette Magelssen, Hanne Blakstad, Janani Moorthy, Karin Andersson, Ingela Raunert, Thomas Henry, Cecilie Moe, Carin Granlund, Dorota Goplen, Jorunn Brekke, Tor-Christian Aase Johannessen, Tora Skeidsvoll Solheim, Kirsten Marienhagen, Øyvind Humberset, Per Bergström, Måns Agrup, Ludvig Dahl, Michael Gubanski, Helene Gojon, Carl-Johan Brahme, Isabelle Rydén, Asgeir S Jakola, Einar O Vik-Mo, Hanne C. Lie, Lars Asphaug, Maziar Hervani, Ingrid Kristensen, Corina Silvia Rueegg, Inge C Olsen, Rolf J Ledal, Eskil Degsell, Katja Werlenius, Malin Blomstrand, Petter Brandal

BMJ Open. 2023; 13(3): e070071. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-070071

PMCID:: PMC10030923

Abstract Article PDF–879K

Effectiveness and feasibility of online fertility preservation decision aids for young female patients with cancer: a systematic review protocol

Ning Qin, Ziyu Wan, Yue Kang, Yating Luo, Yinglong Duan, Jianfei Xie, Andy SK Cheng

BMJ Open. 2023; 13(3): e070294. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-070294

PMCID:: PMC10030757

Abstract Article PDF–338K

Novel patient-centred outcome in cancer care, days at home: a scoping review protocol

Tiago Ribeiro, Alyson Mahar, Angela Jerath, Adom Bondzi-Simpson, Victoria Barabash, Austin A Barr, Frances C Wright, Ekaterina Kosyachkova, Julie Deleemans, Natalie G Coburn, Julie Hallet

BMJ Open. 2023; 13(3): e071201. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-071201

PMCID:: PMC10030791

Abstract Article PDF–397K

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial

Emine Akdemir, Maike G Sweegers, Alina Vrieling, Helene Rundqvist, Richard P Meijer, Annemarie M Leliveld-Kors, Antoine G van der Heijden, Vera C Rutten, Evert L Koldewijn, Siebe D Bos, Carl J Wijburg, Tom A T Marcelissen, Bart C Bongers, Valesca P Retèl, Wim H van Harten, Anne M May, Wim G Groen, Martijn M Stuiver

BMJ Open. 2023; 13(3): e071304. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-071304

PMCID:: PMC10008243

Abstract Article PDF–683K

Ophthalmology

Patient-reported burden and overall impact of dry eye disease across eight European countries: a cross-sectional web-based survey

Kostas G Boboridis, Elisabeth M Messmer, José Benítez-del-Castillo, Juliette Meunier, Brigitte Sloesen, Paul O’Brien, Maria Joao Quadrado, Maurizio Rolando, Marc Labetoulle

BMJ Open. 2023; 13(3): e067007. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-067007

PMCID:: PMC10030789

Abstract Article PDF–1.3M

Socioeconomic position and eye health outcomes: identifying inequality in rapid population-based surveys

Ian McCormick, Min J Kim, Abba Hydara, Segun I Olaniyan, Modou Jobe, Omar Badjie, Nyakassi M B Sanyang, Gibril Jarju, Modou Njai, Alhagie Sankareh, Andrew Bastawrous, Luke Allen, Islay Mactaggart, Matthew J Burton, Jacqueline Ramke

BMJ Open. 2023; 13(3): e069325. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-069325

PMCID:: PMC10008479

Abstract Article PDF–1.4M

Antimicrobial resistance in topical treatments for microbial keratitis: protocol for a systematic review and meta-analysis

Stephen Tuft, Jennifer Evans, Iris Gordon, Astrid Leck, Neil Stone, Timothy Neal, David Macleod, Stephen Kaye, Matthew J Burton

BMJ Open. 2023; 13(3): e069338. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-069338

PMCID:: PMC10008341

Abstract Article PDF–297K

Can artificial intelligence accelerate the diagnosis of inherited retinal diseases? Protocol for a data-only retrospective cohort study (Eye2Gene)

Quang Nguyen, William Woof, Nathaniel Kabiri, Sagnik Sen, Malena Daich Varela, Thales Antonio Cabral De Guimaraes, Mital Shah, Dayyanah Sumodhee, Ismail Moghul, Saoud Al-Khuzaei, Yichen Liu, Catherine Hollyhead, Bhavna Tailor, Loy Lobo, Carl Veal, Stephen Archer, Jennifer Furman, Gavin Arno, Manuel Gomes, Kaoru Fujinami, Savita Madhusudhan, Omar A Mahroo, Andrew R Webster, Konstantinos Balaskas, Susan M Downes, Michel Michaelides, Nikolas Pontikos, Eye2Gene Patient Advisory Group

BMJ Open. 2023; 13(3): e071043. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-071043

PMCID:: PMC10030964

Abstract Article PDF–1.5M

Original Research

Women’s experiences with using patient-reported outcome and experience measures in routine perinatal care in the Netherlands: a mixed-methods study

Lyzette T Laureij, Anne L Depla, Shariva S Kariman, Marije Lamain-de Ruiter, Hiske E Ernst -Smelt, Jan Antonius Hazelzet, Arie Franx, Mireille N Bekker, the BUZZ project team

BMJ Open. 2023; 13(3): e064452. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-064452

PMCID:: PMC10008176

Abstract Article PDF–699K

Paediatrics

Study protocol: peer delivered early intervention (Learning through Everyday Activities with Parents for Infants at risk of Cerebral Palsy: LEAP-CP) for First Nation Australian infants at high risk of cerebral palsy – an RCT study

Katherine Benfer, Roslyn N Boyd, Yvette Roe, Ruth Fagan, Carly Luke, Leeann Mick-Ramsamy, Koa Whittingham, Iona Novak, Margot Bosanquet, Lynda McNamara, Gulam Khandaker, Lucy Fogarty, Yvonne Cadet-James, Alan Ruben, Tracy Comans, Anthony Smith, Robert S Ware

BMJ Open. 2023; 13(3): e059531. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2021-059531

PMCID:: PMC10016288

Abstract Article PDF–670K

Barriers and facilitators of physical function, activity, sports and exercise in children and adolescents with spinal pain: a protocol for a systematic review and meta-ethnography

Susanna Tucker, Nicola R Heneghan, Samia Alamrani, Alison Rushton, Adrian Gardner, Andrew Soundy

BMJ Open. 2023; 13(3): e063946. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-063946

PMCID:: PMC10030483

Abstract Article PDF–460K

Study protocol for economic evaluation of probiotic intervention for prevention of neonatal sepsis in 0–2-month old low-birth weight infants in India: the ProSPoNS trial

Anju Sinha, Pankaj Bahuguna, Subodh Sharan Gupta, Yamini Priyanka Kuruba, Ramesh Poluru, Apoorva Mathur, Dilip Raja, Abhishek V Raut, Kamaleshwar S Mahajan, Rishikesh Sudhakar, Bharati Kulkarni, Ravindra Mohan Pandey, Narendra K. Arora, Shankar Prinja

BMJ Open. 2023; 13(3): e068215. Published online 2023 Mar 29. doi: 10.1136/bmjopen-2022-068215

PMCID:: PMC10069556

Abstract Article PDF–888K

Feasibility evaluation of the Reaching Out to Kids with Emotional Trauma (ROcKET) intervention in an elementary school: a single-arm, single-centre, feasibility study based on the RE-AIM framework

Ellen McMahon, Chelsea Van Wyk, Tavia González Peña, Lauren R Samuels, Leah A Teeters, Sarah B Worsley, William J Heerman

BMJ Open. 2023; 13(3): e068375. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068375

PMCID:: PMC10030927

Abstract Article PDF–512K

Non-invasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in extremely preterm infants with respiratory distress syndrome: study protocol for a multicentre randomised controlled, superiority trial

Yang Li, Xingwang Zhu, Yuan Shi, Noninvasive High-Frequency Oscillatory Ventilation Study Group

BMJ Open. 2023; 13(3): e068450. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-068450

PMCID:: PMC9990689

Abstract Article PDF–466K

Epidemiology of hospitalisations due to chickenpox and quality of life lost in community and hospital settings: protocol for a prospective cohort study across two countries

Robin Marlow, Marion Roderick, Jennifer Oliver, Zoe Jordan, Gayatri Amirthalingam, Jamie Lopez-Bernal, Adam Finn, Fernanda Rodrigues

BMJ Open. 2023; 13(3): e068611. Published online 2023 Mar 29. doi: 10.1136/bmjopen-2022-068611

PMCID:: PMC10069595

Abstract Article PDF–406K

ACTIVE STRIDES-CP: protocol for a randomised trial of intensive rehabilitation (combined intensive gait and cycling training) for children with moderate-to-severe bilateral cerebral palsy

Leanne Sakzewski, Dayna Pool, Ellen Armstrong, Sarah Elizabeth Reedman, Roslyn N Boyd, Catherine Elliott, Iona Novak, Stewart Trost, Robert S Ware, Tracy Comans, Rachel Toovey, Mark D Peterson, Megan Kentish, Sean Horan, Jane Valentine, Sian Williams

BMJ Open. 2023; 13(3): e068774. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068774

PMCID:: PMC10069600

Abstract Article PDF–1.3M

iPAPP: study protocol for a multicentre randomised controlled trial comparing safety and efficacy of intravenous paracetamol and indomethacin for the treatment of patent ductus arteriosus in preterm infants

Fumihiko Namba, Masakazu Honda, Shun Sakatani, Yukiko Motojima, Kayoko Kikuchi, Mayumi Sako, Kunio Ogawa, Masashi Mikami, Kou Kawada, Noriyasu Fukuoka, Keiko Ueda

BMJ Open. 2023; 13(3): e069314. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-069314

PMCID:: PMC10039996

Abstract Article PDF–543K

Examining the experiences of Indigenous families seeking health information about caring for sick or injured children: a scoping review

Lisa Knisley, Janice Linton, S Michelle Driedger, Lisa Hartling, Yuting Sun, Shannon D Scott

BMJ Open. 2023; 13(3): e069697. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-069697

PMCID:: PMC10040012

Abstract Article PDF–1.4M

CATERPILLAR-study protocol: an assessor-blinded randomised controlled trial comparing taurolidine-citrate-heparin to heparin-only lock solutions for the prevention of central line-associated bloodstream infections in paediatric oncology patients

Ceder Hildegard van den Bosch, Yvette Loeffen, Alida F W van der Steeg, Jan-Tom T van der Bruggen, Florine N J Frakking, Marta Fiocco, Cornelis P van de Ven, Marc H W A Wijnen, Marianne D van de Wetering

BMJ Open. 2023; 13(3): e069760. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-069760

PMCID:: PMC10032404

Abstract Article PDF–401K

Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy: a study protocol for the GAME randomised controlled trial

Catherine Morgan, Nadia Badawi, Roslyn N Boyd, Alicia J Spittle, Russell C Dale, Adrienne Kirby, Rod W Hunt, Koa Whittingham, Kerstin Pannek, Rachael L Morton, William Tarnow-Mordi, Michael C Fahey, Karen Walker, Kristina Prelog, Catherine Elliott, Jane Valentine, Andrea Guzzetta, Shannon Olivey, the GAME study team, Iona Novak

BMJ Open. 2023; 13(3): e070649. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-070649

PMCID:: PMC10008404

Abstract Article PDF–627K

Effectiveness of spiritual interventions on psychological outcomes and quality of life among paediatric patients with cancer: a study protocol for a systematic review

Qi Liu, Ka Yan Ho, Katherine Ka Wai Lam, Jacqueline Mei Chi Ho, Winsome Lam, Polly Ma, Hammoda Abu-Odah, Getaneh Mulualem Belay, Dong-Lan Ling, Shirley-Siu-Yin Ching, Frances-Kam-Yuet Wong

BMJ Open. 2023; 13(3): e070810. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-070810

PMCID:: PMC10008432

Abstract Article PDF–271K

Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics (STARSHIP): protocol to study cerebral autoregulation in a prospective multicentre observational research database study

Shruti Agrawal, Michal M Placek, Deborah White, Esther Daubney, Manuel Cabeleira, Peter Smielewski, Marek Czosnyka, Adam Young, Suzanna Watson, Anna Maw, Peter John Hutchinson

BMJ Open. 2023; 13(3): e071800. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2023-071800

PMCID:: PMC10008199

Abstract Article PDF–339K

COllaborative Neonatal Network for the first European CPAM Trial (CONNECT): a study protocol for a randomised controlled trial

Casper M Kersten, Sergei M Hermelijn, Louis W J Dossche, Nagarajan Muthialu, Paul D Losty, Maarten Schurink, André B Rietman, Marten J Poley, Joost van Rosmalen, Tabitha P L Zanen - van den Adel, Pierluigi Ciet, Jan von der Thüsen, Erwin Brosens, Hanneke Ijsselstijn, Harm A W M Tiddens, Rene M H Wijnen, J Marco Schnater

BMJ Open. 2023; 13(3): e071989. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2023-071989

PMCID:: PMC10030930

Abstract Article PDF–676K

Palliative Care

Preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families: a protocol for an umbrella review

Sara Pinto, Silvia Lopes, Andrea Bruno de Sousa, Barbara Gomes

BMJ Open. 2023; 13(3): e066374. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-066374

PMCID:: PMC10069552

Abstract Article PDF–367K

Emergency medical services and palliative care: a scoping review

Caleb Hanson Gage, Charnelle Stander, Liz Gwyther, Willem Stassen

BMJ Open. 2023; 13(3): e071116. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-071116

PMCID:: PMC10030966

Abstract Article PDF–464K

Patient-Centred Medicine

Older patient participation in discharge medication communication: an observational study

Georgia Tobiano, Elizabeth Manias, Lukman Thalib, Gemma Dornan, Trudy Teasdale, Jeremy Wellwood, Wendy Chaboyer

BMJ Open. 2023; 13(3): e064750. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-064750

PMCID:: PMC10040044

Abstract Article PDF–338K

‘It’s so simple’ Lessons from the margins: a qualitative study of patient experiences of a mobile health clinic in Hamilton, Ontario, Canada

Lisa Nussey, Larkin Lamarche, Tim O'Shea

BMJ Open. 2023; 13(3): e066674. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-066674

PMCID:: PMC10040037

Abstract Article PDF–332K

Public Health

Health-seeking behaviour of Ethiopian caregivers when infants are unwell: a descriptive qualitative study

Girmay Kiross, Catherine Chojenta, Daniel Barker, Deborah Loxton

BMJ Open. 2023; 13(3): e051462. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2021-051462

PMCID:: PMC10032389

Abstract Article PDF–286K

Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England

Pui San Tan, Martina Patone, Ashley Kieran Clift, Hajira Dambha-Miller, Defne Saatci, Tom A Ranger, Cesar Garriga, Francesco Zaccardi, Baiju R Shah, Carol Coupland, Simon J Griffin, Kamlesh Khunti, Julia Hippisley-Cox

BMJ Open. 2023; 13(3): e058705. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2021-058705

PMCID:: PMC10030484

Abstract Article PDF–917K

Effect of digital health, biomarker feedback and nurse or midwife-led counselling interventions to assist pregnant smokers quit: a systematic review and meta-analysis

Chadi Tahan, Timothy Dobbins, Fran Hyslop, Raghu Lingam, Robyn Richmond

BMJ Open. 2023; 13(3): e060549. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2021-060549

PMCID:: PMC10040078

Abstract Article PDF–3.2M

Barriers to contraceptive use among secondary school adolescents in Gedeo zone, South Ethiopia: a formative qualitative study

Yohanness Addisu Wondimagegne, Gurmesa Tura Debelew, Zewdie Birhanu Koricha

BMJ Open. 2023; 13(3): e060582. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2021-060582

PMCID:: PMC10069515

Abstract Article PDF–292K

Effects of women’s economic empowerment interventions on antenatal care outcomes: a systematic review

Heezy Suh, Shiri Kalai, Niki Trivedi, Carol Underwood, Zoé Mistrale Hendrickson

BMJ Open. 2023; 13(3): e061693. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-061693

PMCID:: PMC10016312

Abstract Article PDF–1.0M

How do current tobacco warnings compare to the WHO FCTC guidelines: a content analysis of combustible tobacco warnings worldwide

Leah M Ranney, Sonia A Clark, Kristen L Jarman, Allison J Lazard, Sarah D Kowitt, Jennifer Cornacchione Ross, Guido Baler, James F Thrasher, Adam O Goldstein

BMJ Open. 2023; 13(3): e062033. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-062033

PMCID:: PMC10030571

Abstract Article PDF–1.3M

Extent of illicit cigarette market from single stick sales in Ghana: findings from a cross-sectional survey

Arti Singh, Hana Ross, Fiona Dobbie, Allen Gallagher, Tarja Kinnunen, Divine Darlington Logo, Olivia A Boateng, Anna Gilmore, Linda Bauld, Ellis Owusu-Dabo

BMJ Open. 2023; 13(3): e062476. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-062476

PMCID:: PMC10040054

Abstract Article PDF–570K

Using the Johns Hopkins ACG Case-Mix System for population segmentation in a hospital-based adult patient population in Singapore

Joshua Kuan Tan, Xiaojin Zhang, Dawn Cheng, Ian Yi Onn Leong, Chia Siong Wong, Jeannie Tey, Shu Ching Loh, Eugene Fidelis Soh, Wei Yen Lim

BMJ Open. 2023; 13(3): e062786. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-062786

PMCID:: PMC10069494

Abstract Article PDF–1.6M

Can we design the next generation of digital health communication programs by leveraging the power of artificial intelligence to segment target audiences, bolster impact and deliver differentiated services? A machine learning analysis of survey data from rural India

Jean Juste Harrisson Bashingwa, Diwakar Mohan, Sara Chamberlain, Kerry Scott, Osama Ummer, Anna Godfrey, Nicola Mulder, Deshendran Moodley, Amnesty Elizabeth LeFevre

BMJ Open. 2023; 13(3): e063354. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-063354

PMCID:: PMC10030469

Abstract Article PDF–1.4M

Pooled analysis of the association between mental health and violence against women: evidence from five settings in the Global South

Leane Ramsoomar, Andrew Gibbs, Esnat D Chirwa, Mercilene T Machisa, Deda Ogum Alangea, Adolphina Addoley Addo-Lartey, Kristin Dunkle, Rachel Jewkes

BMJ Open. 2023; 13(3): e063730. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-063730

PMCID:: PMC10030569

Abstract Article PDF–480K

Gender integration and female participation in scientific and health research in Zambia: a descriptive cross-sectional study protocol

Cephas Sialubanje, Phyllis Ingutu Sumbwa, Nyondwa Zulu, Nchimunya B Mwanza, Malizgani Paul Chavula, Joseph Zulu

BMJ Open. 2023; 13(3): e064139. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-064139

PMCID:: PMC9990657

Abstract Article PDF–343K

Prevalence of self-medication in Ghana: a systematic review and meta-analysis

Richmond Opoku, Bismark Dwumfour-Asare, Lawrencia Agrey-Bluwey, Nana Esi Appiah, Michael Ackah, Francis Acquah, Priscilla Fordjour Asenso, Abdul-Aziz Issaka

BMJ Open. 2023; 13(3): e064627. Published online 2023 Mar 24. doi: 10.1136/bmjopen-2022-064627

PMCID:: PMC10439347

Abstract Article PDF–550K

Protocol for the PLAY Study: a randomised controlled trial of an intervention to improve infant development by encouraging maternal self-efficacy using behavioural feedback

Alessandra Prioreschi, Rebecca Pearson, Linda Richter, Fiona Bennin, Helene Theunissen, Sarah J Cantrell, Dumsile Maduna, Deborah Lawlor, Shane A Norris

BMJ Open. 2023; 13(3): e064976. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-064976

PMCID:: PMC10008478

Abstract Article PDF–1.7M

Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis

Xuesen Su, Xiaomei Kong, Xiao Yu, Xinri Zhang

BMJ Open. 2023; 13(3): e065114. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-065114

PMCID:: PMC9980323

Abstract Article PDF–1.7M

Engaging lower screening groups: a field experiment to evaluate the impact of a multiwave national campaign on participation in the National Bowel Cancer Screening Program

Claudia Gascoyne, Kate Broun, Belinda Morley, Kerryann Wyatt, Eleonora Feletto, Sarah J Durkin

BMJ Open. 2023; 13(3): e065124. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-065124

PMCID:: PMC10030563

Abstract Article PDF–2.0M

Potentiality of algorithms and artificial intelligence adoption to improve medication management in primary care: a systematic review

Gianfranco Damiani, Gerardo Altamura, Massimo Zedda, Mario Cesare Nurchis, Giovanni Aulino, Aurora Heidar Alizadeh, Francesca Cazzato, Gabriele Della Morte, Matteo Caputo, Simone Grassi, Antonio Oliva, D.3.2 group

BMJ Open. 2023; 13(3): e065301. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-065301

PMCID:: PMC10040015

Abstract Article PDF–526K

Developing a conceptual model of post-disaster damage and loss assessment program in the Iranian health sector: a qualitative study protocol

Javad Miri, Ahmad Reza Raeisi, Golrokh Atighechian, Hesam Seyedin

BMJ Open. 2023; 13(3): e065521. Published online 2023 Mar 22. doi: 10.1136/bmjopen-2022-065521

PMCID:: PMC10040020

Abstract Article PDF–411K

Health engagement: a systematic review of tools modifiable for use with vulnerable pregnant women

Jyai Allen, Debra K Creedy, Kyly Mills, Jenny Gamble

BMJ Open. 2023; 13(3): e065720. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-065720

PMCID:: PMC10008331

Abstract Article PDF–1.1M

Do socioeconomic inequities arise during school-based physical activity interventions? An exploratory case study of the GoActive trial

Olivia Alliott, Hannah Fairbrother, Kirsten Corder, Paul Wilkinson, Esther van Sluijs

BMJ Open. 2023; 13(3): e065953. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-065953

PMCID:: PMC10016273

Abstract Article PDF–628K

Exposure to traumatic events and use of over-the-counter analgesics in adolescents: cross-sectional findings from the Young-HUNT study

Monica Baumann-Larsen, Grete Dyb, Tore Wentzel-Larsen, John-Anker Zwart, Kjersti Storheim, Synne Øien Stensland

BMJ Open. 2023; 13(3): e066058. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-066058

PMCID:: PMC10030485

Abstract Article PDF–327K

Integrating contraceptive services into existing perinatal care: protocol for a community-based cluster randomised controlled trial in Shanghai, China

Longmei Jin, Anxin Yin, Xiaohua Zhang, Hong Jiang, Lu Zhou, Xiaoyan Zhou, Xiurui Wang, Xu Qian

BMJ Open. 2023; 13(3): e066146. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-066146

PMCID:: PMC10032403

Abstract Article PDF–466K

Partner alcohol consumption and intimate partner violence among women in Papua New Guinea: a cross-sectional analysis of Demographic and Health Survey

Abdul Cadri, Richard Gyan Aboagye, James Boadu Frimpong, Paa Akonor Yeboah, Abdul-Aziz Seidu, Bright Opoku Ahinkorah

BMJ Open. 2023; 13(3): e066486. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066486

PMCID:: PMC10016301

Abstract Article PDF–410K

Association of poor perceived work ability and psychosocial work-related factors in health and social service worker age groups: a cross-sectional study

Kirsikka Selander, Risto Nikunlaakso, Eveliina Korkiakangas, Timo Sinervo, Jaana Laitinen

BMJ Open. 2023; 13(3): e066506. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-066506

PMCID:: PMC9990690

Abstract Article PDF–299K

Use of qualitative systems mapping and causal loop diagrams to understand food environments, diet and obesity: a scoping review protocol

Ivana Stankov, Rosie Mae Henson, Irene Headen, Jonathan Purtle, Brent A Langellier

BMJ Open. 2023; 13(3): e066875. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-066875

PMCID:: PMC10030560

Abstract Article PDF–261K

Neighbourhood environment as a risk factor for adverse health outcomes through association with the microbiome: protocol for a scoping review

Nicole Farmer, Alyssa Baginski, Jenna Alkhatib, Katherine A Maki, Yvonne Baumer, Tiffany M Powell-Wiley, Gwenyth R Wallen

BMJ Open. 2023; 13(3): e066913. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-066913

PMCID:: PMC10008260

Abstract Article PDF–293K

Mapping definitions, measures and methodologies of assessing police violence in the health literature: a scoping review protocol

Latesha K Harris, Jamie L Conklin, Cheryl L Woods-Giscombe, Yamnia I Cortés

BMJ Open. 2023; 13(3): e066946. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-066946

PMCID:: PMC10030772

Abstract Article PDF–285K

Is spatial exposure to heritage associated with visits to heritage and to mental health? A cross-sectional study using data from the UK Household Longitudinal Study (UKHLS)

Laura Macdonald, Natalie Nicholls, Eirini Gallou, Linda Monckton, Richard Mitchell

BMJ Open. 2023; 13(3): e066986. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-066986

PMCID:: PMC10069496

Abstract Article PDF–566K

Study design and rationale for the PAASIM project: a matched cohort study on urban water supply improvements and infant enteric pathogen infection, gut microbiome development and health in Mozambique

Karen Levy, Joshua V Garn, Zaida Adriano Cumbe, Bacelar Muneme, Christine S Fagnant-Sperati, Sydney Hubbard, Antonio Júnior, João Luís Manuel, Magalhães Mangamela, Sandy McGunegill, Molly K Miller-Petrie, Jedidiah S Snyder, Courtney Victor, Lance A Waller, Konstantinos T Konstantinidis, Thomas F Clasen, Joe Brown, Rassul Nalá, Matthew C Freeman

BMJ Open. 2023; 13(3): e067341. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-067341

PMCID:: PMC9990653

Abstract Article PDF–4.7M

Adherence to Mediterranean diet in Italy (ARIANNA) cross-sectional survey: study protocol

Erica Cardamone, Rita Di Benedetto, Giulia Lorenzoni, Silvia Gallipoli, Marco Ghidina, Federica Zobec, Francesca Iacoponi, Dario Gregori, Marco Silano

BMJ Open. 2023; 13(3): e067534. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-067534

PMCID:: PMC9980321

Abstract Article PDF–314K

Opioid prescriptions after knee replacement: a retrospective study of pathways and prognostic factors in the Swiss healthcare setting

Kevin Wirth, Caroline Bähler, Stefan Boes, Markus Näpflin, Carola A Huber, Eva Blozik

BMJ Open. 2023; 13(3): e067542. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-067542

PMCID:: PMC10008278

Abstract Article PDF–833K

Are there inequalities in the attendance and effectiveness of behavioural weight management interventions for adults in the UK? Protocol for an individual participant data (IPD) meta-analysis

Jack M Birch, Julia Mueller, Stephen Sharp, Jennifer Logue, Michael P Kelly, Simon J Griffin, Amy Ahern

BMJ Open. 2023; 13(3): e067607. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-067607

PMCID:: PMC10039995

Abstract Article PDF–342K

Prevalence, treatment outcomes and determinants of TB–HIV coinfection: a 10-year retrospective review of TB registry in Kwabre East Municipality of Ghana

Emmanuel Osei Bonsu, Isaac Yeboah Addo, Benjamin Noble Adjei, Muhib Mohammed Alhassan, Emmanuel Kweku Nakua

BMJ Open. 2023; 13(3): e067613. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-067613

PMCID:: PMC10040042

Abstract Article PDF–594K

A mixed-methods study measuring the effectiveness of a menstrual health intervention on menstrual health knowledge, perceptions and practices among young women in Zimbabwe

Mandikudza Tembo, Helen A Weiss, Leyla Sophie Larsson, Tsitsi Bandason, Nicol Redzo, Ethel Dauya, Tafadzwa Nzanza, Pauline Ishumael, Nancy Gweshe, Precious Ndlovu, Chido Dziva Chikwari, Constancia Vimbayi Mavodza, Jenny Renju, Suzanna C Francis, Rashida Ferrand, Constance R S Mackworth-Young

BMJ Open. 2023; 13(3): e067897. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-067897

PMCID:: PMC10008401

Abstract Article PDF–571K

Development of rapid and effective risk prediction models for stroke in the Chinese population: a cross-sectional study

Yuexin Qiu, Shiqi Cheng, Yuhang Wu, Wei Yan, Songbo Hu, Yiying Chen, Yan Xu, Xiaona Chen, Junsai Yang, Xiaoyun Chen, Huilie Zheng

BMJ Open. 2023; 13(3): e068045. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-068045

PMCID:: PMC9980356

Abstract Article PDF–1017K

Analysis of national and subnational prevalence of adolescent pregnancy and changes in the associated sexual behaviours and sociodemographic determinants across three decades in Ghana, 1988–2019

Shamsudeen Mohammed

BMJ Open. 2023; 13(3): e068117. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-068117

PMCID:: PMC10030779

Abstract Article PDF–2.2M

Heatwaves, hospitals and health system resilience in England: a qualitative assessment of frontline perspectives from the hot summer of 2019

Katya Brooks, Owen Landeg, Sari Kovats, Mark Sewell, Emer OConnell

BMJ Open. 2023; 13(3): e068298. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-068298

PMCID:: PMC9990610

Abstract Article PDF–437K

Active travel to school: a longitudinal millennium cohort study of schooling outcomes

Ian Walker, Tim Gamble

BMJ Open. 2023; 13(3): e068388. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-068388

PMCID:: PMC10040056

Abstract Article PDF–332K

Growth patterns in childhood and adolescence and adult body composition: a pooled analysis of birth cohort studies from five low and middle-income countries (COHORTS collaboration)

Natalia E Poveda, Linda S Adair, Reynaldo Martorell, Shivani A Patel, Manuel Ramirez-Zea, Santosh K Bhargava, Sonny A Bechayda, Delia B Carba, Maria F Kroker-Lobos, Bernardo Lessa Horta, Natália Peixoto Lima, Mónica Mazariegos, Ana Maria Baptista Menezes, Shane A Norris, Lukhanyo H Nyati, Linda M Richter, Harshpal Sachdev, Fernando C Wehrmeister, Aryeh D Stein

BMJ Open. 2023; 13(3): e068427. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-068427

PMCID:: PMC10030655

Abstract Article PDF–1.0M

Youth’s engagement and perceptions of disposable e-cigarettes: a UK focus group study

Marissa J Smith, Anne Marie MacKintosh, Allison Ford, Shona Hilton

BMJ Open. 2023; 13(3): e068466. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068466

PMCID:: PMC10040067

Abstract Article PDF–310K

Study design and methods of the Wells and Enteric disease Transmission (WET) Trial: a randomised controlled trial

Debbie Lee, Donna Denno, Phillip Tarr, Jingwei Wu, Joel P Stokdyk, Mark Borchardt, Heather M Murphy

BMJ Open. 2023; 13(3): e068560. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-068560

PMCID:: PMC9990626

Abstract Article PDF–2.7M

Nutritional and dietary diversity status of under-5 children and adolescent girls among forcibly displaced Myanmar nationals living in Bhasan Char relocation camp, Bangladesh: a cross-sectional survey

Subhasish Das, Shah Mohammad Fahim, Md Golam Rasul, Sazia Afrin, Md Ashraful Alam, Mahabub Uz Zaman, Morseda Chowdhury, Shams El Arifeen, Tahmeed Ahmed

BMJ Open. 2023; 13(3): e068875. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-068875

PMCID:: PMC10069579

Abstract Article PDF–1.3M

Identification of the elements of models of antimicrobial resistance of bacteria for assessing their usefulness and usability in One Health decision making: a protocol for scoping review

Kamal Raj Acharya, Jhoana P Romero-Leiton, Elizabeth Jane Parmley, Bouchra Nasri

BMJ Open. 2023; 13(3): e069022. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-069022

PMCID:: PMC10030675

Abstract Article PDF–599K

Telehealth use in primary healthcare collaborative interprofessional practice: protocol for a scoping review

Gisele Silvestre Belber, Raíssa Ottes Vasconcelos, Heloise Lima Fernandes Agreli, Ana Estela Haddad, Marina Peduzzi, Valéria Marli Leonello

BMJ Open. 2023; 13(3): e069163. Published online 2023 Mar 17. doi: 10.1136/bmjopen-2022-069163

PMCID:: PMC10030669

Abstract Article PDF–239K

Menstrual health and hygiene among young Palestinian female university students in the West Bank: a cross-sectional study

Sahar Hassan, Rula Ghandour, Lamia Bakri, Siham Shwiki, Sara Safi, Reem Abuzaid, Hiba Zeidan

BMJ Open. 2023; 13(3): e069222. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-069222

PMCID:: PMC10069603

Abstract Article PDF–297K

Determinants of childhood vaccination among children aged 12–23 months in Ethiopia: a community-based cross-sectional study

Sewunet Sako, Girma Gilano, Samuel Hailegebreal

BMJ Open. 2023; 13(3): e069278. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-069278

PMCID:: PMC10008449

Abstract Article PDF–505K

Global overview of pharmacy support personnel training programmes: a scoping review protocol

Simangele Hlongwana, Sizwe Makhunga, Thembelihle Dlungwane

BMJ Open. 2023; 13(3): e069279. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069279

PMCID:: PMC10069568

Abstract Article PDF–696K

Care seeking for under-five children and vaccine perceptions during the first two waves of the COVID-19 pandemic in Lagos State, Nigeria: a qualitative exploratory study

Ayobami Adebayo Bakare, Omotayo E Olojede, Carina King, Hamish Graham, Obioma Uchendu, Tim Colbourn, Adegoke G Falade, Helle Molsted Alvesson

BMJ Open. 2023; 13(3): e069294. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-069294

PMCID:: PMC10008198

Abstract Article PDF–414K

Vaccine coverage for recommended vaccines among splenectomised patients in Apulia, South Italy: a retrospective cohort study

Francesco Paolo Bianchi, Pasquale Stefanizzi, Antonio Di Lorenzo, Eustachio Cuscianna, Silvio Tafuri, Cinzia Annatea Germinario

BMJ Open. 2023; 13(3): e069316. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-069316

PMCID:: PMC10069564

Abstract Article PDF–382K

Analysis of the determinants of sleep quality in a Spanish population: a study protocol for a cross-sectional study

César Jiménez-Vaquero, Rosario Alonso-Dominguez, Irene A Garcia-Yu, Ana M Martín-Nogueras, Natalia Sánchez-Aguadero, Andrea Crespo-Sedano, María I Rihuete-Galve, María A García-Alonso, María L García-Prieto, Jesús González-Sánchez, José-Ignacio Recio

BMJ Open. 2023; 13(3): e069444. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-069444

PMCID:: PMC10008228

Abstract Article PDF–375K

Differential attainment in specialty training recruitment in the UK: an observational analysis of the impact of psychometric testing assessment in Public Health postgraduate selection

Richard J Pinder, Fran Bury, Ganesh Sathyamoorthy, Azeem Majeed, Mala Rao

BMJ Open. 2023; 13(3): e069738. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-069738

PMCID:: PMC10008157

Abstract Article PDF–393K

Common health assets protocol: a mixed-methods, realist evaluation and economic appraisal of how community-led organisations (CLOs) impact on the health and well-being of people living in deprived areas

Rachel Mairi Baker, Mohasin Ahmed, Marcello Bertotti, John Cassidy, Rejoice Chipuriro, Emma Clewett, Cam Donaldson, Andrew Elders, Lee Ann Fenge, Julie Fox, Karen Galway, Aideen Gildea, Aileen McGuinness, Jennifer McLean, Sarkis Manoukian, Helen Mason, Antony Morgan, Jill Mulholland, Liam O'Hare, Andrew Paterson, Sam Porter, Jack Rendall, Michael J Roy, Peter Seaman, Merron Simpson, Artur Steiner, Michael P Kelly

BMJ Open. 2023; 13(3): e069979. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-069979

PMCID:: PMC10030928

Abstract Article PDF–3.1M

Georgia McCarty, Emma H Wyeth, Trudy Sullivan, Sue Crengle, Vicky Nelson, Sarah Derrett

BMJ Open. 2023; 13(3): e070156. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-070156

PMCID:: PMC10069609

Abstract Article PDF–743K

Reducing the incidence and impact of peer-to-peer online trolling: a protocol for a scoping review

Amanda Tracy Beatson, Aimee Riedel, Rory Mulcahy, Byron William Keating, Shasha Wang, Marilyn Campbell, Daniel Johnson

BMJ Open. 2023; 13(3): e070460. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-070460

PMCID:: PMC10016285

Abstract Article PDF–299K

Health literacy education programmes developed for qualified health professionals: a scoping review

Lauren Connell, Yvonne Finn, Jane Sixsmith

BMJ Open. 2023; 13(3): e070734. Published online 2023 Mar 30. doi: 10.1136/bmjopen-2022-070734

PMCID:: PMC10069593

Abstract Article PDF–493K

Sociodemographic factors associated to knowledge and attitudes towards dengue prevention among the Peruvian population: findings from a national survey

Daniel Fernandez-Guzman, Brenda Caira-Chuquineyra, Pablo M Calderon-Ramirez, Shanelin Cisneros-Alcca, Raysa M Benito-Vargas

BMJ Open. 2023; 13(3): e071236. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-071236

PMCID:: PMC10032396

Abstract Article PDF–673K

Qualitative Research

Factors underpinning an improved menopausal experience in the workplace for doctors: a UK-based qualitative study

Yasmin Adelekan-Kamara, Mohammed-Hareef Asunramu, Karmanpreet Bhullar, Kwaku Agyei Duah-Asante, Kathleen Leedham-Green, Anika Madaan, Daryl Poku, Samineh Yousefi

BMJ Open. 2023; 13(3): e060265. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2021-060265

PMCID:: PMC10008158

Abstract Article PDF–2.2M

Qualitative study exploring the feasibility of using medication monitors and a differentiated care approach to support adherence among people receiving TB treatment in South Africa

Rachel Mukora, Noriah Maraba, Catherine Orrell, Lauren Jennings, Pren Naidoo, M Thulani Mbatha, Kavindhran Velen, Katherine Fielding, Salome Charalambous, Candice Maylene Chetty-Makkan

BMJ Open. 2023; 13(3): e065202. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-065202

PMCID:: PMC9990642

Abstract Article PDF–402K

Women and health professionals’ perspectives on a conditional cash transfer programme to improve pregnancy follow-up: a qualitative analysis of the NAITRE randomised controlled study

Marc Bardou, Nicolas Meunier-Beillard, Aurélie Godard-Marceau, Philippe Deruelle, Claude Virtos, Astrid Eckman-Lacroix, Elodie Debras, Thomas Schmitz, the NAITRE Study group

BMJ Open. 2023; 13(3): e067066. Published online 2023 Mar 29. doi: 10.1136/bmjopen-2022-067066

PMCID:: PMC10069550

Abstract Article PDF–464K

Qualitative interview study exploring the early identification and referral of patients with suspected head and neck cancer by community pharmacists in England

Andrew Sturrock, Susan M Bissett, Marco Carrozzo, Rachel Lish, Debora Howe, Sue Mountain, Michael Nugent, James O’Hara, Philip M Preshaw, Adam Todd, Scott Wilkes

BMJ Open. 2023; 13(3): e068607. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-068607

PMCID:: PMC10008169

Abstract Article PDF–501K

Patient perspectives on indwelling urinary catheters and fluid balances after transsphenoidal pituitary surgery: a qualitative study

Jeanne-Marie Nollen, Anja H Brunsveld-Reinders, Wilco C Peul, Wouter R van Furth

BMJ Open. 2023; 13(3): e069598. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2022-069598

PMCID:: PMC10030659

Abstract Article PDF–275K

Indwelling experience and coping strategies of upper arm infusion ports in patients with cancer: a qualitative study

Yawen Wang, Xiyi Wang, Xiaoxia Qiu

BMJ Open. 2023; 13(3): e069772. Published online 2023 Mar 22. doi: 10.1136/bmjopen-2022-069772

PMCID:: PMC10040049

Abstract Article PDF–284K

Radiology and Imaging

Do imaging findings modify the effect of non-surgical treatment in patients with knee and hip osteoarthritis? A systematic literature review

Stine Clausen, Joshua Heerey, Jan Hartvigsen, Joanne L Kemp, Bodil Arnbak

BMJ Open. 2023; 13(3): e065373. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-065373

PMCID:: PMC10030490

Abstract Article PDF–913K

Rehabilitation Medicine

Evaluation of the impact of a smartphone application on adherence to home exercise program for people with chronic low back pain: research protocol for a pilot randomised controlled trial

Jean-Baptiste Lechauve, Lech Dobija, Bruno Pereira, Maxime Grolier, Anna Goldstein, Charlotte Lanhers, Emmanuel Coudeyre

BMJ Open. 2023; 13(3): e062290. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-062290

PMCID:: PMC10040032

Abstract Article PDF–1.0M

Adherence to physical rehabilitation delivered via tele-rehabilitation for people with multiple sclerosis: a scoping review protocol

Geraldine Goldsmith, Jessica C Bollen, Victoria E Salmon, Jennifer A Freeman, Sarah G Dean

BMJ Open. 2023; 13(3): e062548. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-062548

PMCID:: PMC10008230

Abstract Article PDF–409K

Transcranial direct current stimulation combined with bodyweight support–tai chi footwork for motor function of stroke survivors: a study protocol of randomised controlled trial

Ming-hui Lai, Hai-chen Xu, Meng-cui Huang, Yan Lu, Kun Yang, Li-ming Jiang, Xiao-ming Yu

BMJ Open. 2023; 13(3): e065338. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-065338

PMCID:: PMC10008177

Abstract Article PDF–1.2M

Development of a tool for objectively measuring somatic pain in the low back region based on a longitudinal diagnostic study conducted in Karachi, Pakistan

Rasim ul Hasanat, Shahzad Ali Syed, Farooq Azam Rathore, Sundus Iftikhar

BMJ Open. 2023; 13(3): e067129. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-067129

PMCID:: PMC10030883

Abstract Article PDF–450K

Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates—protocol for a descriptive cross-sectional study

Marika C Möller, Nils Berginström, Bijar Ghafouri, Anna Holmqvist, Monika Löfgren, Love Nordin, Britt-Marie Stålnacke

BMJ Open. 2023; 13(3): e068011. Published online 2023 Mar 29. doi: 10.1136/bmjopen-2022-068011

PMCID:: PMC10069545

Abstract Article PDF–546K

Effects of non-invasive brain stimulation (NIBS) for executive function on subjects with ADHD: a protocol for a systematic review and meta-analysis

Lihong Peng, Liyan Tian, Tiantian Wang, Qiu Wang, Na Li, Hui Zhou

BMJ Open. 2023; 13(3): e069004. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-069004

PMCID:: PMC9990641

Abstract Article PDF–836K

Renal Medicine

Effect of Intravenous Ferric Carboxymaltose on Exercise Capacity After Kidney Transplantation (EFFECT-KTx): rationale and study protocol for a double-blind, randomised, placebo-controlled trial

Joanna SJ Vinke, Michele F Eisenga, Jan-Stephan F Sanders, Stefan P Berger, Jacoba M Spikman, Wayel H Abdulahad, Stephan JL Bakker, Carlo A J M Gaillard, Arjan D van Zuilen, P van der Meer, Martin H de Borst

BMJ Open. 2023; 13(3): e065423. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-065423

PMCID:: PMC10040026

Abstract Article PDF–634K

Prediction of cardiovascular death and non-fatal cardiovascular events by the Kidney age–Chronological age Difference (KCD) score in men and women of different ages in a community-based cohort

Duncan J Campbell, Dianna J Magliano, Jonathan E Shaw

BMJ Open. 2023; 13(3): e068494. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-068494

PMCID:: PMC10008409

Abstract Article PDF–1.1M

Evaluation of safety, effectiveness and treatment patterns of sodium zirconium cyclosilicate in management of hyperkalaemia in China: a real-world study protocol

Nan Shen, Qingyang Meng, Lihong Zhang, Hua Xie, Jianrong Zhao, Changying Xing, Li Zuo, Gang Long, Qiang Zhu, Chunyan Shan, Xudong Cai, Jing Yang, Xun Luo, Jianmin Wang, Jianming Ye, Xin Wan, Shaojiang Tian, Yifan Wu, Yongqiang Lin, Xiaoyong Yu, Qing Li, Xinyu Liu, Zhenwei Shi, Jingwei Zhou, Chunyan Liu, Yanping Cao, Niansong Wang, Xinxin Jiang, Henglan Wu, Yao Hu, Lu Li, Zhaohua Wang, Jingdong He, Juan Cao, Fenglei Wu, Cong Ma, Xun Yin, Zhongxin Li, Huimin Wang, Hongli Lin

BMJ Open. 2023; 13(3): e070530. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-070530

PMCID:: PMC10008460

Abstract Article PDF–366K

Reproductive Medicine

Early initiation of breast feeding and associated factors among mother-baby dyads with immediate skin-to-skin contact: cross-sectional study based on the 2016 Ethiopian Demographic and Health Survey data

Girma Teferi Mengistu, Bizunesh Kefale Mengistu

BMJ Open. 2023; 13(3): e063258. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-063258

PMCID:: PMC10069540

Abstract Article PDF–453K

Research Methods

Effect of and the association between vitamin D and outcomes of assisted reproductive techniques among infertile men and women: protocol for an overview of systematic reviews and meta-analysis

Bahar Morshed-Behbahani, Leila Doryanizadeh, Shadab Shahali, Saeed Shahabi, Ali Montazeri

BMJ Open. 2023; 13(3): e060483. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2021-060483

PMCID:: PMC10008453

Abstract Article PDF–294K

Registry randomised trials: a methodological perspective

Dorota A Doherty, Steven Y C Tong, Jennifer Reilly, Jane Shrapnel, Stephen McDonald, Susannah Ahern, Ian Harris, Charmaine S Tam, Angela L Brennan, Carol Hodgson, Leonie Wilcox, Anitha Balagurunathan, Belinda E Butcher, Christopher M Reid

BMJ Open. 2023; 13(3): e068057. Published online 2023 Mar 1. doi: 10.1136/bmjopen-2022-068057

PMCID:: PMC9980340

Abstract Article PDF–576K

Respiratory Medicine

Phase III, two arm, multi-centre, open label, parallel-group randomised designed clinical investigation of the use of a personalised early warning decision support system to predict and prevent acute exacerbations of chronic obstructive pulmonary disease: ‘Predict & Prevent AECOPD’ – study protocol

Dalbir Kaur, Rajnikant L Mehta, Hugh Jarrett, Sue Jowett, Nicola K Gale, Alice M Turner, Monica Spiteri, Neil Patel

BMJ Open. 2023; 13(3): e061050. Published online 2023 Mar 13. doi: 10.1136/bmjopen-2022-061050

PMCID:: PMC10016266

Abstract Article PDF–405K

Clinical–functional characteristics and risk of exacerbation and mortality among more symptomatic patients with chronic obstructive pulmonary disease: a retrospective cohort study

Qing Song, Ling Lin, Wei Cheng, Xue-Shan Li, Yu-Qin Zeng, Cong Liu, Min-Hua Deng, Dan Liu, Zhi-Ping Yu, Xin Li, Li-Bing Ma, Yan Chen, Shan Cai, Ping Chen

BMJ Open. 2023; 13(3): e065625. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-065625

PMCID:: PMC10032416

Abstract Article PDF–630K

Changes in mortality among patients with chronic obstructive pulmonary disease from the 1990s to the 2000s: a pooled analysis of two prospective cohort studies

Susumu Sato, Toru Oga, Shigeo Muro, Kazuya Tanimura, Naoya Tanabe, Koichi Nishimura, Toyohiro Hirai

BMJ Open. 2023; 13(3): e065896. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-065896

PMCID:: PMC10008372

Abstract Article PDF–632K

Early diagnostic BioMARKers in exacerbations of chronic obstructive pulmonary disease: protocol of the exploratory, prospective, longitudinal, single-centre, observational MARKED study

Kiki Waeijen-Smit, Antonio DiGiandomenico, Jessica Bonnell, Kristoffer Ostridge, Ulf Gehrmann, Bret R Sellman, Tara Kenny, Sander van Kuijk, Daphne Peerlings, Martijn A Spruit, Sami O Simons, Sarah Houben-Wilke, Frits M E Franssen

BMJ Open. 2023; 13(3): e068787. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-068787

PMCID:: PMC9990620

Abstract Article PDF–693K

Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world risk modelling study

Tae Yoon Lee, Mohsen Sadatsafavi, Chandra Prakash Yadav, David B Price, Richard Beasley, Christer Janson, Mariko Siyue Koh, Rupsa Roy, Wenjia Chen

BMJ Open. 2023; 13(3): e070459. Published online 2023 Mar 9. doi: 10.1136/bmjopen-2022-070459

PMCID:: PMC10008482

Abstract Article PDF–501K

Rheumatology

Discontinuation of tofacitinib and TNF inhibitors in patients with rheumatoid arthritis: analysis of pooled data from two registries in Canada

Mohammad Movahedi, Denis Choquette, Louis Coupal, Angela Cesta, Xiuying Li, Edward C Keystone, Claire Bombardier, OBRI Investigators

BMJ Open. 2023; 13(3): e063198. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-063198

PMCID:: PMC9990670

Abstract Article PDF–398K

Inequity and vulnerability in Latin American Indigenous and non-Indigenous populations with rheumatic diseases: a syndemic approach

Ysabel Granados, Alfonso Gastelum Strozzi, Jose Alvarez-Nemegyei, Rosana Quintana, Flor Julian-Santiago, Ana M Santos, Sergio Guevara-Pacheco, Adalberto Loyola-Sanchez, Maria Victoria Goycochea-Robles, Vicente Juarez, Mario Alberto Garza-Elizondo, Juan Camilo Rueda, Ruben Burgos-Vargas, John Londoño, Bernardo A Pons-Estel, Ingris Pelaez-Ballestas

BMJ Open. 2023; 13(3): e069246. Published online 2023 Mar 23. doi: 10.1136/bmjopen-2022-069246

PMCID:: PMC10040077

Abstract Article PDF–803K

Sexual Health

Sexual health promotion for sexual and gender minorities in primary care: a scoping review protocol

Paige Homme, Robinson Truong, Jenny Gong, Carolyn Ziegler, Cassandra Freitas, Anna Yeung, Darrell HS Tan, Ann N Burchell

BMJ Open. 2023; 13(3): e066704. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-066704

PMCID:: PMC9990650

Abstract Article PDF–271K

Smoking and Tobacco

Smoking cessation interventions for US adults with disabilities: protocol for a systematic review

Jonathan A Schulz, Gary S Atwood, Sean D Regnier, Lindsey C Mullis, Austin Nugent, Tyler G Erath, Andrea C Villanti

BMJ Open. 2023; 13(3): e066700. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-066700

PMCID:: PMC10040063

Abstract Article PDF–284K

Sports and Exercise Medicine

Understanding the role of physical activity on the pathway from intra-articular knee injury to post-traumatic osteoarthritis disease in young people: a scoping review protocol

Karl Morgan, James Cowburn, Matthew Farrow, Josh Carter, Dario Cazzola, Jean-Philippe Walhin, Carly McKay

BMJ Open. 2023; 13(3): e067147. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-067147

PMCID:: PMC9990625

Abstract Article PDF–737K

Effects of physical, psychosocial and dual-career loads on injuries and illnesses among elite handball players: protocol of prospective cohort study

Kristina Drole, Armin Paravlic, Kathrin Steffen, Mojca Doupona

BMJ Open. 2023; 13(3): e069104. Published online 2023 Mar 2. doi: 10.1136/bmjopen-2022-069104

PMCID:: PMC9990604

Abstract Article PDF–345K

Investigating post-mild traumatic brain injury neuromuscular function and musculoskeletal injury risk: A protocol for a prospective, observational, case–controlled study in service members and active individuals

Robert C Lynall, Joseph G Wasser, Daniel I Brooks, Jarrod A Call, Brad D Hendershot, Joseph R Kardouni, Julianne D Schmidt, Timothy C Mauntel

BMJ Open. 2023; 13(3): e069404. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-069404

PMCID:: PMC10039998

Abstract Article PDF–636K

Surgery

Artificial intelligence as a diagnostic aid in cross-sectional radiological imaging of surgical pathology in the abdominopelvic cavity: a systematic review

George E Fowler, Natalie S Blencowe, Conor Hardacre, Mark P Callaway, Neil J Smart, Rhiannon Macefield

BMJ Open. 2023; 13(3): e064739. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-064739

PMCID:: PMC9990659

Abstract Article PDF–537K

Ultrasound-guided Jamshidi needle puncture to reduce radiation exposure during percutaneous pedicle screw placement: study protocol for a randomised controlled trial

Tong Wu, Yi-feng Chen, Ying Huang, Fan-he Meng, Jing-han Lu, Da Liu

BMJ Open. 2023; 13(3): e064838. Published online 2023 Mar 10. doi: 10.1136/bmjopen-2022-064838

PMCID:: PMC10008456

Abstract Article PDF–632K

Greener Operations: a James Lind Alliance Priority Setting Partnership to define research priorities in environmentally sustainable perioperative practice through a structured consensus approach

Max Clayton-Smith, Hrishi Narayanan, Clifford Shelton, Louise Bates, Fiona Brennan, Beck Diedo, Mike Donnellon, Jenny Dorey, Bob Evans, Jonathan Gower, Yasmina Hamdaoui, John Hitchman, S Michael Kinsella, Rebecca Knagg, Cathy Lawson, Daniel Morris, Victoria Pegna, Tracey Radcliffe, Olivia Schaff, Tim Sheppard, Jennifer Strong, David Jones

BMJ Open. 2023; 13(3): e066622. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-066622

PMCID:: PMC10069275

Abstract Article PDF–1012K

Impact of minimally invasive surgery on surgeon health (ISSUE) study: protocol of a single-arm observational study conducted in the live surgery setting

Anumithra Amirthanayagam, Massimiliano Zecca, Shaun Barber, Baljit Singh, Esther L Moss

BMJ Open. 2023; 13(3): e066765. Published online 2023 Mar 7. doi: 10.1136/bmjopen-2022-066765

PMCID:: PMC10008445

Abstract Article PDF–715K

Effectiveness and cost-effectiveness of a digital health intervention to support patients with colorectal cancer prepare for and recover from surgery: study protocol of the RecoverEsupport randomised controlled trial

Rebecca Wyse, Stephen Smith, Alison Zucca, Kristy Fakes, Elise Mansfield, Sally-Ann Johnston, Sancha Robinson, Christopher Oldmeadow, Penny Reeves, Mariko L Carey, Grace Norton, Rob W Sanson-Fisher

BMJ Open. 2023; 13(3): e067150. Published online 2023 Mar 6. doi: 10.1136/bmjopen-2022-067150

PMCID:: PMC9990701

Abstract Article PDF–511K

Dose and administration time of indocyanine green in near-infrared fluorescence cholangiography during laparoscopic cholecystectomy (DOTIG): study protocol for a randomised clinical trial

Jaime López-Sánchez, Sonsoles Garrosa-Muñoz, Fernando Pardo Aranda, Clara Gené Škrabec, Ricardo López Pérez, Patricia Rodríguez-Fortúnez, José Manuel Sánchez Santos, Luis Muñoz-Bellvís, DOTIG Collaborative Group

BMJ Open. 2023; 13(3): e067794. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-067794

PMCID:: PMC9990661

Abstract Article PDF–480K

Local anaesthetic infiltration in rubber band ligation of rectal haemorrhoids: study protocol for a three-arm, double-blind randomised controlled trial (PLATIPUS trial)

Eleanor G R Watson, Kirby R Qin, Philip J Smart, Adele N Burgess, Helen M Mohan, David M Proud

BMJ Open. 2023; 13(3): e067896. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2022-067896

PMCID:: PMC10008167

Abstract Article PDF–838K

Efficacy of indocyanine green systemic administration for bile leak detection after hepatectomy: a protocol for a prospective single-arm clinical trial with a historical control group

Takehiko Hanaki, Keisuke Goto, Naruo Tokuyasu, Yusuke Endo, Hiroshi Sunada, Hisashi Noma, Teppei Sunaguchi, Yuki Murakami, Tomoyuki Matsunaga, Manabu Yamamoto, Teruhisa Sakamoto, Toshimichi Hasegawa, Yoshiyuki Fujiwara

BMJ Open. 2023; 13(3): e068223. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-068223

PMCID:: PMC10032385

Abstract Article PDF–519K

Role of single-dose intravenous iron therapy for the treatment of anaemia after orthopaedic trauma: protocol for a pilot randomised controlled trial

Danielle F Peterson, Natasha S McKibben, Catherine E Hutchison, Karalynn Lancaster, Chih Jen Yang, Graham J Dekeyser, Darin M Friess, Martin A Schreiber, Nick J Willett, Joseph J Shatzel, Joseph E Aslan, Zachary M Working

BMJ Open. 2023; 13(3): e069070. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-069070

PMCID:: PMC10032390

Abstract Article PDF–2.1M

Impact of a digital surgical workflow including Digital Device Briefing Tool on morbidity and mortality in a patient population undergoing primary stapled colorectal anastomosis for benign or malignant colorectal disease: protocol for a multicentre prospective cohort study

Johannes Lauscher, Katharina Beyer, Achim Hellinger, Roland S Croner, Karsten Ridwelski, Christian Krautz, Christine Lim, Paul M Coplan, Marc Kurepkat, Goran Ribaric

BMJ Open. 2023; 13(3): e070053. Published online 2023 Mar 27. doi: 10.1136/bmjopen-2022-070053

PMCID:: PMC10069574

Abstract Article PDF–366K

Partnering to build surgical capacity in low-resource settings: a qualitative study of Canadian global surgeons

Muhammad Uzair Khalid, Amanda Mac, Maya Biderman, Lee Errett, Abi Sriharan

BMJ Open. 2023; 13(3): e070148. Published online 2023 Mar 21. doi: 10.1136/bmjopen-2022-070148

PMCID:: PMC10040043

Abstract Article PDF–1.3M

Effect of oral pre-emptive analgesia on pain management after total knee arthroplasty: a protocol for systematic review and meta-analysis

Fan-jie Xiong, Wei Zhao, Shi-jian Jia, Xiao-rong Huang, Xiang-fei Luo, Hong-jiang Pu, Kai Song, Yan-ming Li

BMJ Open. 2023; 13(3): e070998. Published online 2023 Mar 15. doi: 10.1136/bmjopen-2022-070998

PMCID:: PMC10030931

Abstract Article PDF–446K

Urology

Efficacy and safety of apalutamide in patients with metastatic castration-resistant prostate cancer (GENESIS): protocol for a multicentre, open-label, single-arm clinical trial

Hideaki Miyake, Yasumasa Kakei, Yuzo Nakano, Tomoaki Terakawa, Keiko Miyakoda, Kenichi Harada, Masato Fujisawa

BMJ Open. 2023; 13(3): e070173. Published online 2023 Mar 28. doi: 10.1136/bmjopen-2022-070173

PMCID:: PMC10069569

Abstract Article PDF–295K

Corrections

Correction: Maternal vitamin D intake and BMI during pregnancy in relation to child’s growth and weight status from birth to 8 years: a large national cohort study

BMJ Open. 2023; 13(3): e048980corr1. Published online 2023 Mar 8. doi: 10.1136/bmjopen-2021-048980corr1

Corrects:: BMJ Open. 2021; 11(10): e048980.

PMCID:: PMC10175963

Correction PDF–101K

Correction: Factors Associated with the Magnitude Of acUpuncture treatment effectS (FAMOUS): a meta-epidemiological study of acupuncture randomised controlled trials

BMJ Open. 2023; 13(3): e060237Corr1. Published online 2023 Mar 20. doi: 10.1136/bmjopen-2021-060237Corr1

Corrects:: BMJ Open. 2022; 12(8): e060237.

PMCID:: PMC10111574

Correction PDF–101K

Correction: Impact of minimum unit pricing on alcohol-related hospital outcomes: systematic review

BMJ Open. 2023; 13(3): e065220corr1. Published online 2023 Mar 3. doi: 10.1136/bmjopen-2022-065220corr1

Corrects:: BMJ Open. 2023; 13(2): e065220.

PMCID:: PMC10175961

Correction PDF–101K

Correction for Healthcare waste management practice and its predictors among health workers in private health facilities in Ilu Aba Bor Zone, Oromia region, South West Ethiopia: a community-based cross-sectional study

BMJ Open. 2023; 13(3): e067752corr1. Published online 2023 Mar 14. doi: 10.1136/bmjopen-2022-067752corr1

Corrects:: BMJ Open. 2023; 13(2): e067752.

PMCID:: PMC10030643

Correction PDF–104K

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