Protein Family Models

Date:

2024-05-15

Date:

2024-05-15

Date:

2024-05-15

Members of this family are lipoproteins about 135 amino acids long from Mycoplasmopsis agalactiae and Mycoplasmopsis bovis.

Date:

2024-05-15

This narrowly defined lipoprotein family appears restricted to Mesomycoplasma ovipneumoniae. It is related to LppA family surface lipoproteins.

Date:

2024-05-15

Gene:

purE

Date:

2024-05-10

Date:

2024-05-10

Date:

2024-05-10

Date:

2024-05-10

Gene:

cikA

Date:

2024-05-10

Gene:

manS

Date:

2024-05-10

Gene:

cikB

Date:

2024-05-10

Gene:

mntA

Date:

2024-05-10

Gene:

petB

Date:

2024-05-07

Gene:

vanS-I

Date:

2024-04-20

PNGM-1, a metallo-hydrolase with a metallo-beta-lactamase (MBL) fold and barely detectable sequence homology to subclass B3, was cloned from a deep-sea sediment metagenome by screening for reduced sensitivity to ampicillin. No close homolog of PNGM-1 has been found in any cultured organism, and the protein also shows tRNase Z activity. The closest homolog with a known biological role is GntH, an MBL fold protein with a role in the biosynthesis of guanitoxin, an organophospate molecule that covalently and therefore irreversibly inhibitis acetylcholinesterase. While PNGM-1, hydrolyzes a number of beta-lactam antibiotics, the natural primary biological role of PNGM-1 is unknown.

Gene:

blaPNGM

Date:

2024-04-21

SPS-1 differs from most recognized subclass B1 metallo-beta-lactamases in having a different site and mechanism for binding a critical Zn ion, and scoring below the curated cutoff scores of the general HMM for subclass B1 enzymes. SPS-1 is active against carbapenems and certain cephalosporins.

Gene:

blaSPS

Date:

2024-04-19

Gene:

tet(X1)

Date:

2024-04-18

Gene:

erm(N)

Date:

2024-04-18

This HMM describes the MATE family efflux protein NorM as found in Burkholderia vietnamiensis and related species. Vibrio and Neisseria families given the same name are described by separate models.

Gene:

norM

Date:

2024-04-18