Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block
- PMID: 16218462
- DOI: 10.1191/0961203305lu2195oa
Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block
Abstract
When anti-SSA/Ro antibodies are present in sera of mothers with connective tissue diseases, the incidence of congenital heart block (CHB) has been reported to be 1-2% in live births. The risk of recurrence of CHB in a subsequent child remains limited to 10-16%. CHBs are usually complete but CHB of the first or second degree can also be observed. In some cases, CHB is associated with endocardial fibroelastosis. Late-onset cardiomyopathy may occur later in life in these children. The mortality of CHB, which is predominant in utero and in the first months of life, is an estimated 16-19%. A pacemaker is required in about 66% of cases. Curative treatment of CHB is based on fluorinated steroids (dexamethasone or betamethasone) that do cross the placenta in an active form. Guidelines are available but further studies are needed to optimize treatment.
Similar articles
-
[Neonatal lupus syndrome: Literature review].Rev Med Interne. 2015 Mar;36(3):159-66. doi: 10.1016/j.revmed.2014.07.013. Epub 2014 Sep 17. Rev Med Interne. 2015. PMID: 25240481 Review. French.
-
Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects.Arthritis Rheum. 2005 Oct;52(10):3079-86. doi: 10.1002/art.21289. Arthritis Rheum. 2005. PMID: 16200587
-
[Congenital heart block associated with maternal anti SSA/SSB antibodies :a report of four cases].Pathol Biol (Paris). 2004 Apr;52(3):138-47. doi: 10.1016/j.patbio.2003.06.002. Pathol Biol (Paris). 2004. PMID: 15063933 Review. French.
-
Neonatal lupus: bedside to bench and back.Scand J Rheumatol. 1996;25(5):271-6. doi: 10.3109/03009749609104057. Scand J Rheumatol. 1996. PMID: 8921918 Review.
-
Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block.J Rheumatol. 1996 May;23(5):925-32. J Rheumatol. 1996. PMID: 8724310
Cited by
-
Molecular Mechanisms of Fetal and Neonatal Lupus: A Narrative Review of an Autoimmune Disease Transferal across the Placenta.Int J Mol Sci. 2024 May 10;25(10):5224. doi: 10.3390/ijms25105224. Int J Mol Sci. 2024. PMID: 38791261 Free PMC article. Review.
-
Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine.Rheumatology (Oxford). 2023 Mar 1;62(3):1124-1135. doi: 10.1093/rheumatology/keac372. Rheumatology (Oxford). 2023. PMID: 35766806 Free PMC article.
-
Fetal Congenital Heart Block Associated With Maternal Primary Systemic Lupus Erythematosus and Sjogren's Syndrome.Cureus. 2021 Sep 16;13(9):e18036. doi: 10.7759/cureus.18036. eCollection 2021 Sep. Cureus. 2021. PMID: 34671524 Free PMC article.
-
Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.Hum Mutat. 2021 Oct;42(10):1279-1293. doi: 10.1002/humu.24265. Epub 2021 Jul 29. Hum Mutat. 2021. PMID: 34289528 Free PMC article.
-
Autoimmune Congenital Heart Block: A Review of Biomarkers and Management of Pregnancy.Front Pediatr. 2020 Dec 22;8:607515. doi: 10.3389/fped.2020.607515. eCollection 2020. Front Pediatr. 2020. PMID: 33415090 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials