Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview
- PMID: 16601863
- DOI: 10.1007/s10545-006-0106-5
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview
Abstract
Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease. Homocysteine is a branch-point intermediate of methionine metabolism, which can be further metabolised via two alternative pathways: degraded irreversibly through the transsulphuration pathway or remethylated to methionine by the remethylation pathway. Both pathways are B-vitamin-dependent. Plasma homocysteine concentrations are determined by nongenetic and genetic factors. The metabolism of homocysteine, the role of B vitamins and the contribution of nongenetic and genetic determinants of homocysteine concentrations are reviewed. The mechanisms whereby homocysteine causes endothelial damage and vascular disease are not fully understood. Recently, a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern. The involvement of epigenetic mechanisms in the context of homocysteine and atherosclerosis, due to inhibition of transmethylation reactions, is briefly overviewed.
Similar articles
-
Genetics of hyperhomocysteinaemia in cardiovascular disease.Ann Clin Biochem. 2003 Jan;40(Pt 1):46-59. doi: 10.1258/000456303321016169. Ann Clin Biochem. 2003. PMID: 12542910 Review.
-
[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data].Pathol Biol (Paris). 2003 Mar;51(2):101-10. doi: 10.1016/s0369-8114(03)00104-4. Pathol Biol (Paris). 2003. PMID: 12801808 Review. French.
-
Nutritional aspects and possible pathological mechanisms of hyperhomocysteinaemia: an independent risk factor for vascular disease.Proc Nutr Soc. 2000 May;59(2):221-37. doi: 10.1017/s0029665100000252. Proc Nutr Soc. 2000. PMID: 10946791 Review.
-
B-vitamins, homocysteine metabolism and CVD.Proc Nutr Soc. 2004 Nov;63(4):597-603. doi: 10.1079/pns2004390. Proc Nutr Soc. 2004. PMID: 15831132 Review.
-
Hyperhomocysteinemia: an additional cardiovascular risk factor.WMJ. 1999 Dec;98(8):51-4. WMJ. 1999. PMID: 10639897 Review.
Cited by
-
Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression.Clin Epigenetics. 2024 Apr 24;16(1):57. doi: 10.1186/s13148-024-01668-0. Clin Epigenetics. 2024. PMID: 38659084 Free PMC article.
-
One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy.J Anim Sci. 2024 Jan 3;102:skae044. doi: 10.1093/jas/skae044. J Anim Sci. 2024. PMID: 38407272
-
Early Life Origins of Cardio-Metabolic Outcomes in Boston Birth Cohort: Review of Findings and Future directions.Precis Nutr. 2023 Sep;2(3):e00050. Epub 2023 Sep 27. Precis Nutr. 2023. PMID: 38283709 No abstract available.
-
Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.J Gastrointest Cancer. 2024 Jun;55(2):778-786. doi: 10.1007/s12029-024-01020-y. Epub 2024 Jan 22. J Gastrointest Cancer. 2024. PMID: 38252186 Free PMC article.
-
Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases.Front Aging Neurosci. 2024 Jan 4;15:1322419. doi: 10.3389/fnagi.2023.1322419. eCollection 2023. Front Aging Neurosci. 2024. PMID: 38239489 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical