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Review

Avalglucosidase Alfa

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
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Review

Avalglucosidase Alfa

No authors listed.
Free Books & Documents

Excerpt

Minimal information is available on the clinical use of avalglucosidase during breastfeeding. Because avalglucosidase is a large protein molecule with a molecular weight of about 124,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] One infant breastfed during maternal avalglucosidase therapy beginning at 2 months postpartum with no apparent adverse effects.

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References

    1. Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 - DOI
    1. Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. - PubMed
    1. Yanagihara C, Hayasaka Y, Kageyama Y. Pregnancy during enzyme replacement therapy with alglucosidase alfa over a 14-year period in late-onset Pompe disease. Neurol Clin Neurosci 2023;11:97-9. doi:10.1111/ncn3.12695 - DOI

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