PubMed (MeSH Keyword) for id: 51

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[Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome].

Li Y, Wang Y, Yuan Q. Li Y, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 May 20;55(3):783-792. doi: 10.12182/20240560302. Sichuan Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 38948289 Free PMC article. Review. Chinese.

Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism.

Jasinska W, Dindo M, Cordoba SMC, Serohijos AWR, Laurino P, Brotman Y, Bershtein S. Jasinska W, et al. Nat Commun. 2024 Jun 20;15(1):5285. doi: 10.1038/s41467-024-49646-7. Nat Commun. 2024. PMID: 38902266 Free PMC article.

An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO.

Pan J, Wenger ES, Lin CY, Zhang B, Sil D, Schaperdoth I, Saryazdi S, Grossman RB, Krebs C, Bollinger JM Jr. Pan J, et al. Biochemistry. 2024 Jul 2;63(13):1674-1683. doi: 10.1021/acs.biochem.4c00166. Epub 2024 Jun 19. Biochemistry. 2024. PMID: 38898603 Free PMC article.

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway.

He R, Wei Y, Peng Z, Yang J, Zhou Z, Li A, Wu Y, Wang M, Li X, Zhao D, Liu Z, Dong H, Leng X. He R, et al. Cell Mol Biol Lett. 2024 Jun 14;29(1):88. doi: 10.1186/s11658-024-00605-6. Cell Mol Biol Lett. 2024. PMID: 38877424 Free PMC article.

α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway.

Cheng D, Zhang M, Zheng Y, Wang M, Gao Y, Wang X, Liu X, Lv W, Zeng X, Belosludtsev KN, Su J, Zhao L, Liu J. Cheng D, et al. Redox Biol. 2024 Aug;74:103230. doi: 10.1016/j.redox.2024.103230. Epub 2024 Jun 13. Redox Biol. 2024. PMID: 38875959 Free PMC article.

An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein.

Burns D, Khatiwada B, Singh A, Purslow JA, Potoyan DA, Venditti V. Burns D, et al. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2404457121. doi: 10.1073/pnas.2404457121. Epub 2024 Jun 12. Proc Natl Acad Sci U S A. 2024. PMID: 38865275

Development of bovine serum albumin-modified Fe₃O₄ embedded in porous α-ketoglutaric acid/chitosan (BSA/Fe₃O₄@KA/CS): A magnetically targeted hemostatic dressing for deep and irregular wounds.

Guo J, Zhao Y, Peng G, Ye T, Zhu X, Li R, Shen J, Du L, Wang S, Meng Z, Gan H, Gu R, Sun W, Dou G, Liu S, Sun Y. Guo J, et al. Int J Biol Macromol. 2024 Jun;272(Pt 2):132923. doi: 10.1016/j.ijbiomac.2024.132923. Epub 2024 Jun 5. Int J Biol Macromol. 2024. PMID: 38848835

Rational engineering of Halomonas salifodinae to enhance hydroxyectoine production under lower-salt conditions.

Yang N, Liu M, Han J, Jiang M, Zeng Y, Liu Y, Xiang H, Zheng Y. Yang N, et al. Appl Microbiol Biotechnol. 2024 May 31;108(1):353. doi: 10.1007/s00253-024-13197-0. Appl Microbiol Biotechnol. 2024. PMID: 38819481 Free PMC article.

[Exploration of mechanism of total triterpenoids from fruits of Chaenomeles speciosa against senescent GES-1 cells induced by D-galactose based on Gln/GLS1/α-KG metabolic axis and mitochondrial apoptosis signaling pathway].

He JY, Yang JX, Qin SY, Zheng JQ, Guo YR, Ma TX. He JY, et al. Zhongguo Zhong Yao Za Zhi. 2024 Apr;49(8):2230-2246. doi: 10.19540/j.cnki.cjcmm.20231212.707. Zhongguo Zhong Yao Za Zhi. 2024. PMID: 38812238 Chinese.

The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A.

Thomas MG, Jaber Sathik Rifayee SB, Chaturvedi SS, Gorantla KR, White W, Wildey J, Schofield CJ, Christov CZ. Thomas MG, et al. Inorg Chem. 2024 Jun 10;63(23):10737-10755. doi: 10.1021/acs.inorgchem.4c01365. Epub 2024 May 23. Inorg Chem. 2024. PMID: 38781256

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