RSS-Feed abonnieren
DOI: 10.1055/s-0035-1556142
Measures of success in translational research
The ultimate measure of success in industrial natural products R&D is the launch of a new commercial product. In reality this is a rare event, particularly for those involved in the earliest stages of R&D (Discovery). Regardless of the eventual commercial outcome, which may be governed by business considerations rather than science, there are many achievements in “translational research” that should be recognized as measures of success. Each time an issue that constitutes a roadblock to further product development is overcome, there are valuable lessons learned that may be helpful in subsequent programs. In this presentation I will cover examples of such stepwise problem solving that helped advance natural product R&D projects originating from discoveries made at American Cyanamid Co. (Lederle Laboratories).
-
Dioxapyrrolomycin insecticide lead. Issue: preparation of analogs for SAR
-
Ganefromycin animal health & growth promotion: stability & supply
-
Mannopeptimycin antibiotic lead: IP protection; stability & bioavailability
During this time period the best known examples of translational success were the development of moxidectin (Cydectin) as an antiparasitic agent for animals, tigecycline antibiotic (Tygacil) to overcome resistance to the tetracyclines and the heroic crafting of calicheamicin (Mylotarg) as a payload for antibody-drug conjugate programs.