Version 5.4
Homo sapiens Gene: CACNA1G
Summary
InnateDB Gene IDBG-58847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNA1G
Gene Name calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms Ca(V)T.1; Cav3.1; NBR13
Species Homo sapiens
Ensembl Gene ENSG00000006283
Encoded Proteins
IDBP-58849
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-58851
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-58855
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-58857
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-58859
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-381704
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-381712
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-381714
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-481554
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-481547
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-480378
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-485163
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-473867
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-481591
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-483864
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-484383
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-485162
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-485485
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-479886
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-475322
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-478660
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-479466
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-474915
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-482083
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-482733
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-473624
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-474009
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-480643
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-475276
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-478538
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-476799
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-482788
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-485482
calcium channel, voltage-dependent, T type, alpha 1G subunit
IDBP-760015
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50561068-50627474
Strand Forward strand
Band q21.33
Transcripts
ENST00000354983 ENSP00000347078
ENST00000359106 ENSP00000352011
ENST00000352832 ENSP00000339302
ENST00000360761 ENSP00000353990
ENST00000358244 ENSP00000350979
ENST00000429973 ENSP00000414388
ENST00000442258 ENSP00000409759
ENST00000416767 ENSP00000392390
ENST00000502264 ENSP00000425522
ENST00000512389 ENSP00000426261
ENST00000513964 ENSP00000425451
ENST00000514717 ENSP00000422407
ENST00000510366 ENSP00000426814
ENST00000503485 ENSP00000427238
ENST00000507510 ENSP00000423112
ENST00000511765 ENSP00000427247
ENST00000507336 ENSP00000420918
ENST00000506406 ENSP00000426313
ENST00000504076 ENSP00000425153
ENST00000513689 ENSP00000426172
ENST00000507609 ENSP00000423045
ENST00000503436 ENSP00000427231
ENST00000510115 ENSP00000427173
ENST00000515165 ENSP00000426098
ENST00000514181 ENSP00000425698
ENST00000515765 ENSP00000426232
ENST00000514079 ENSP00000423317
ENST00000507896 ENSP00000421518
ENST00000511768 ENSP00000424664
ENST00000505165 ENSP00000422268
ENST00000503607 ENSP00000426558
ENST00000515411 ENSP00000423155
ENST00000506520 ENSP00000427697
ENST00000570567 ENSP00000459988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008332 low voltage-gated calcium channel activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001508 action potential
GO:0002027 regulation of heart rate
GO:0006810 transport
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0010045 response to nickel cation
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0055085 transmembrane transport
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020866
View Gene Order
ENSBTAG00000009835
Not yet available
Pathways
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591169
RefSeq NM_001256324 NM_001256325 NM_001256326 NM_001256327 NM_001256328 NM_001256329 NM_001256330 NM_001256331 NM_001256332 NM_001256333 NM_001256334 NM_001256359 NM_001256360 NM_001256361 NM_018896 NM_198376 NM_198377 NM_198378 NM_198379 NM_198380 NM_198382 NM_198383 NM_198384 NM_198385 NM_198386 NM_198387 NM_198388 NM_198396 XM_006722160
HUGO
OMIM
CCDS CCDS45730 CCDS45731 CCDS45732 CCDS45733 CCDS45734 CCDS45735 CCDS45736 CCDS45737 CCDS54142 CCDS54143 CCDS54144 CCDS54145 CCDS54146 CCDS58565 CCDS58566 CCDS58567 CCDS58568 CCDS58569 CCDS58570 CCDS58571 CCDS58572 CCDS58573 CCDS58574 CCDS58575 CCDS58576
HPRD 04961
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca

-