Homo sapiens Protein: CACNA1G | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-58855.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CACNA1G | ||||||||||||||||||||||
Protein Name | calcium channel, voltage-dependent, T type, alpha 1G subunit | ||||||||||||||||||||||
Synonyms | Ca(V)T.1; Cav3.1; NBR13; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000339302 | ||||||||||||||||||||||
InnateDB Gene | IDBG-58847 (CACNA1G) | ||||||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||||||
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. | ||||||||||||||||||||||
Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR005445
Voltage-dependent calcium channel, T-type, alpha-1 subunit IPR005821 Ion transport domain IPR013122 Polycystin cation channel, PKD1/PKD2 |
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PFAM |
PF00520
PF08016 |
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PRINTS |
PR01629
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PIRSF | |||||||||||||||||||||||
SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O43497 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O43497 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8913 | ||||||||||||||||||||||
UniGene | Hs.591169 | ||||||||||||||||||||||
RefSeq | NP_938201 | ||||||||||||||||||||||
HUGO | HGNC:1394 | ||||||||||||||||||||||
OMIM | 604065 | ||||||||||||||||||||||
CCDS | CCDS45735 | ||||||||||||||||||||||
HPRD | 04961 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB032949 AC004590 AC021491 AF029228 AF029229 AF124351 AF126965 AF126966 AF134985 AF134986 AF190860 AF227744 AF227745 AF227746 AF227747 AF227748 AF227749 AF227750 AF227751 BC110995 DQ494449 DQ494450 DQ494451 DQ494452 DQ494453 DQ494454 DQ494455 DQ494456 DQ494457 DQ494458 DQ494459 DQ494460 DQ494461 DQ494462 DQ494463 DQ494464 DQ494465 DQ494466 DQ494467 DQ494468 DQ494469 DQ494470 DQ494471 DQ494472 DQ494473 DQ494474 DQ494475 DQ494476 DQ494477 DQ494478 DQ494479 | ||||||||||||||||||||||
GenPept | AAD12731 AAD12732 AAD29400 AAD29401 AAD34352 AAF19346 AAF19347 AAF35287 AAF37689 AAF37690 AAF37691 AAF37692 AAF37693 AAF37694 AAF37695 AAF37696 AAI10996 ABF69900 ABF69901 ABF69902 ABF69903 ABF69904 ABF69905 ABF69906 ABF69907 ABF69908 ABF69909 ABF69910 ABF69911 ABF69912 ABF69913 ABF69914 ABF69915 ABF69916 ABF69917 ABF69918 ABF69919 ABF69920 ABF69921 ABF69922 ABF69923 ABF69924 ABF69925 ABF69926 ABF69927 ABF69928 ABF69929 ABF69930 BAA86437 | ||||||||||||||||||||||