Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the world health organization 2004 bladder consensus classification
- PMID: 16217372
- DOI: 10.1097/01.ju.0000176801.16827.82
Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the world health organization 2004 bladder consensus classification
Abstract
Purpose: Urothelial neoplasms in patients younger than 20 years are rare, with conflicting data regarding clinical outcomes.
Materials and methods: We identified 23 patients 4 to 20 years old with urothelial neoplasms, reclassified the microscopic diagnoses using the 2004 WHO/International Society of Urologic Pathology grading classification and collected data on presentation, risk factors and outcomes.
Results: Pathological grading revealed 2 urothelial papillomas, 10 papillary urothelial neoplasms of low malignant potential (PUNLMPs), and 8 low grade and 3 high grade papillary urothelial cancers, all without invasion. Mean patient age was 13.2 years (range 4 to 20), 19 patients were male and 19 presented with gross hematuria. All lesions were solitary and measured 0.1 to 6 cm. One patient had a history of smoking and 1 had parents who smoked. Three patients (13%) had recurrences classified as either urothelial papilloma (1) or PUNLMP (2). All patients were alive with no evidence of disease after a mean followup of 4.5 years (range 6 months to 13 years).
Conclusions: Urothelial neoplasms in individuals younger than 20 years more commonly occur in males and are predominantly low grade with a favorable clinical outcome. Before the current classification system the 10 patients with a diagnosis of PUNLMP would have been classified as having papillary carcinoma. Thus, the diagnostic category of PUNLMP allowed 43.5% of patients in this series to avoid being labeled with "cancer" at a young age.
Similar articles
-
Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management.Adv Anat Pathol. 2011 Jan;18(1):79-89. doi: 10.1097/PAP.0b013e318204c0cf. Adv Anat Pathol. 2011. PMID: 21169741 Review.
-
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.Pathol Int. 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. Pathol Int. 2010. PMID: 20055945 Review.
-
Comparison of american joint committee on cancer pathological stage T2a versus T2b urothelial carcinoma: analysis of patient outcomes in organ confined bladder cancer.J Urol. 2009 Feb;181(2):540-5; discussion 546. doi: 10.1016/j.juro.2008.10.038. Epub 2008 Dec 13. J Urol. 2009. PMID: 19084855
-
Comparison of the WHO/ISUP classification and cytokeratin 20 expression in predicting the behavior of low-grade papillary urothelial tumors. World/Health Organization/Internattional Society of Urologic Pathology.Mod Pathol. 2001 Apr;14(4):267-72. doi: 10.1038/modpathol.3880300. Mod Pathol. 2001. PMID: 11301341
-
Flat intraepithelial lesions of the urinary bladder.Cancer. 2000 Feb 1;88(3):625-31. Cancer. 2000. PMID: 10649257
Cited by
-
Bladder Neoplasia in Pediatric Patients-A Single-Center Experience Including a Case Series.Children (Basel). 2023 Sep 25;10(10):1596. doi: 10.3390/children10101596. Children (Basel). 2023. PMID: 37892259 Free PMC article.
-
Non-muscle invasive urothelial bladder cancer in a 17-year-old male: A rare case report.Int J Surg Case Rep. 2023 Sep;110:108728. doi: 10.1016/j.ijscr.2023.108728. Epub 2023 Aug 29. Int J Surg Case Rep. 2023. PMID: 37683512 Free PMC article.
-
Low-grade papillary urothelial neoplasm: A case report study.Radiol Case Rep. 2023 Jun 15;18(9):2895-2899. doi: 10.1016/j.radcr.2023.05.055. eCollection 2023 Sep. Radiol Case Rep. 2023. PMID: 37388533 Free PMC article.
-
Coexistent urothelial papilloma and ureteric calculus in an 8-year-old child: A rare co-occurrence.J Postgrad Med. 2021 Jul-Sep;67(3):182-183. doi: 10.4103/jpgm.JPGM_300_20. J Postgrad Med. 2021. PMID: 33380592 Free PMC article. No abstract available.
-
Urothelial bladder carcinoma in childhood: a case report.Pan Afr Med J. 2020 Jun 15;36:91. doi: 10.11604/pamj.2020.36.91.20416. eCollection 2020. Pan Afr Med J. 2020. PMID: 32774650 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical