Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel
- PMID: 22879540
- DOI: 10.1182/blood-2012-03-362608
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel
Abstract
Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an international expert panel of the International BFM Study Group AML Committee was to set standards for the management, diagnosis, response assessment, and treatment in childhood AML. This paper aims to discuss differences between childhood and adult AML, and to highlight recommendations that are specific to children. The particular relevance of new diagnostic and prognostic molecular markers in pediatric AML is presented. The general management of pediatric AML, the management of specific pediatric AML cohorts (such as infants) or subtypes of the disease occurring in children (such as Down syndrome related AML), as well as new therapeutic approaches, and the role of supportive care are discussed.
Similar articles
-
Treatment strategies for adolescent and young adult patients with acute myeloid leukemia.Blood. 2018 Jul 26;132(4):362-368. doi: 10.1182/blood-2017-12-778472. Epub 2018 Jun 12. Blood. 2018. PMID: 29895667 Review.
-
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28. Blood. 2017. PMID: 27895058 Free PMC article. Review.
-
[Progress in the diagnosis and treatment of childhood AML].Rinsho Ketsueki. 2015 Oct;56(10):2220-9. doi: 10.11406/rinketsu.56.2220. Rinsho Ketsueki. 2015. PMID: 26458463 Japanese.
-
Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.J Clin Oncol. 2015 Sep 20;33(27):2949-62. doi: 10.1200/JCO.2015.62.8289. Epub 2015 Aug 24. J Clin Oncol. 2015. PMID: 26304895 Free PMC article. Review.
-
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.Blood. 2010 Jan 21;115(3):453-74. doi: 10.1182/blood-2009-07-235358. Epub 2009 Oct 30. Blood. 2010. PMID: 19880497 Review.
Cited by
-
Treatment outcomes of pediatrics acute myeloid leukemia (AML) and associated factors in the country's tertiary referral hospital, Ethiopia.BMC Cancer. 2024 May 24;24(1):640. doi: 10.1186/s12885-024-12404-5. BMC Cancer. 2024. PMID: 38789952 Free PMC article.
-
Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid Leukemia.Cancers (Basel). 2024 Apr 26;16(9):1693. doi: 10.3390/cancers16091693. Cancers (Basel). 2024. PMID: 38730645 Free PMC article.
-
Anti-leukemia effects of ginsenoside monomer: A narrative review of pharmacodynamics study.Curr Ther Res Clin Exp. 2024 Feb 25;100:100739. doi: 10.1016/j.curtheres.2024.100739. eCollection 2024. Curr Ther Res Clin Exp. 2024. PMID: 38706463 Free PMC article. Review.
-
Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway.J Cancer Res Clin Oncol. 2024 May 4;150(5):231. doi: 10.1007/s00432-024-05753-y. J Cancer Res Clin Oncol. 2024. PMID: 38703241 Free PMC article.
-
Clinical features of immature leukemias in children.Int J Hematol. 2024 Apr 30. doi: 10.1007/s12185-024-03771-7. Online ahead of print. Int J Hematol. 2024. PMID: 38687412
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous