Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience
- PMID: 10655254
- DOI: 10.1002/hep.510310211
Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience
Abstract
The prognosis for patients with hepatocellular carcinoma (HCC) is poor because of the low chance of curative treatment. To increase the chance of intervention and to improve survival, early detection of subclinical HCC (SCHCC) by alpha-fetoprotein (AFP) and/or ultrasonography (USG) screening is implemented in many countries. Three hundred six Chinese patients with HCC diagnosed between January 1995 and December 1997 were recruited. They were categorized into two groups: 142 patients (group 1) had SCHCC diagnosed by screening (AFP and/or USG), and 164 patients (group 2) presented with symptomatic HCC. The tumor size was significantly smaller in group 1 compared with that of group 2 (3.5 cm vs. 8.1 cm; P <.0001). A significantly higher proportion of patients had bilobar involvement, multifocal HCC, diffuse-type HCC, portal vein infiltration, and distant metastasis in group 2 when compared with group 1. Operability and feasibility of treatment by transcatheter intra-arterial chemoembolization (TACE) in group 1 patients (26.8% and 45.1%, respectively) were significantly better than in group 2 patients (7.9% and 32.3%, P <.0001 and P =.03, respectively). The cumulative survival rate was significantly higher in group 1 than in group 2 (P <.0001). For those who had surgical resection and those who had TACE, group 1 patients had a higher cumulative survival rate compared with that of group 2 patients (P =.04 and P =.0003, respectively). Screening for HCC by AFP and/or USG can identify tumors at an early stage, resulting in a higher chance of receiving treatment. Whether it can improve survival requires a further prospective, randomized study.
Similar articles
-
Optimal treatment increased survival of hepatocellular carcinoma patients detected with community-based screening.J Gastroenterol Hepatol. 2010 Aug;25(8):1426-34. doi: 10.1111/j.1440-1746.2010.06285.x. J Gastroenterol Hepatol. 2010. PMID: 20659234
-
Clinical benefits of hepatocellular carcinoma surveillance: a single-center, hospital-based study.Oncol Rep. 2005 Oct;14(4):999-1003. Oncol Rep. 2005. PMID: 16142364
-
Subclinical hepatocellular carcinoma in Hong Kong Chinese.Oncology. 1992;49(5):347-53. doi: 10.1159/000227071. Oncology. 1992. PMID: 1382257
-
Hepatocellular carcinoma: update on diagnosis and treatment.Dig Dis. 1995 Mar-Apr;13(2):81-91. doi: 10.1159/000171490. Dig Dis. 1995. PMID: 7586635 Review.
-
[Screening of hepatocellular carcinoma: role of the alpha-fetoprotein (AFP) and ultrasonography].Recenti Prog Med. 2005 Jun;96(6):295-9; quiz 328. Recenti Prog Med. 2005. PMID: 16078760 Review. Italian.
Cited by
-
Hepatocellular carcinoma: Advances in systemic therapies.F1000Res. 2024 May 7;13:104. doi: 10.12688/f1000research.145493.2. eCollection 2024. F1000Res. 2024. PMID: 38766497 Free PMC article. Review.
-
Predicting Survival Using Whole-Liver MRI Radiomics in Patients with Hepatocellular Carcinoma After TACE Refractoriness.Cardiovasc Intervent Radiol. 2024 Jul;47(7):964-977. doi: 10.1007/s00270-024-03730-z. Epub 2024 May 15. Cardiovasc Intervent Radiol. 2024. PMID: 38750156
-
Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes.Cell Cycle. 2024 Jan;23(1):15-35. doi: 10.1080/15384101.2024.2305535. Epub 2024 Jan 22. Cell Cycle. 2024. PMID: 38252499
-
Somatostatin and Somatostatin Receptors in Tumour Biology.Int J Mol Sci. 2023 Dec 28;25(1):436. doi: 10.3390/ijms25010436. Int J Mol Sci. 2023. PMID: 38203605 Free PMC article. Review.
-
Integrating DNA methylation and gene expression data in a single gene network using the iNETgrate package.Sci Rep. 2023 Dec 8;13(1):21721. doi: 10.1038/s41598-023-48237-8. Sci Rep. 2023. PMID: 38066050 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous