Neural correlates of tasting concentrated quinine and sugar solutions
- PMID: 11826070
- DOI: 10.1152/jn.00358.2001
Neural correlates of tasting concentrated quinine and sugar solutions
Abstract
Behavioral, ethological, and electrophysiological evidence suggests that the highly unpleasant, bitter taste of a concentrated quinine hydrochloride (QHCL) should activate the human amygdala. In the present study, healthy subjects tasted 0.02 M QHCL or water while regional cerebral blood flow (rCBF) was assayed with H(2)(15)O PET. Subjects were also studied while tasting a pleasant sucrose solution and resting with eyes closed (ECR). Tasting QHCL significantly increased rCBF within the left amygdala relative to control conditions of tasting water and ECR. Sucrose and water caused small to moderate rCBF increases in the amygdala relative to ECR, but sucrose did not significantly increase activity within either amygdalae relative to water. In the frontal lobe, QHCL and sucrose both activated the right posterior orbitofrontal cortex (OFC) relative to water, but portions of the anterior OFC and inferior frontal pole showed valence specific responses to QHCL. These data indicate that the left amygdala responds robustly to QHCL and more moderately to nonaversive sapid stimuli, both pleasant and unpleasant gustatory stimuli activate the right posterior OFC, and the left inferior frontal pole/anterior OFC demonstrates valence-specific responses to aversive gustatory stimuli.
Similar articles
-
Aversive gustatory stimulation activates limbic circuits in humans.Brain. 1998 Jun;121 ( Pt 6):1143-54. doi: 10.1093/brain/121.6.1143. Brain. 1998. PMID: 9648549
-
Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects.Am J Psychiatry. 1999 Oct;156(10):1618-29. doi: 10.1176/ajp.156.10.1618. Am J Psychiatry. 1999. PMID: 10518175
-
Representation of pleasant and aversive taste in the human brain.J Neurophysiol. 2001 Mar;85(3):1315-21. doi: 10.1152/jn.2001.85.3.1315. J Neurophysiol. 2001. PMID: 11248000 Clinical Trial.
-
Responses of primate cortical neurons to unitary and binary taste stimuli.J Neurophysiol. 1996 Jan;75(1):396-411. doi: 10.1152/jn.1996.75.1.396. J Neurophysiol. 1996. PMID: 8822566
-
Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies.Cereb Cortex. 2000 Mar;10(3):308-17. doi: 10.1093/cercor/10.3.308. Cereb Cortex. 2000. PMID: 10731225 Review.
Cited by
-
Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis.PLoS One. 2024 Mar 22;19(3):e0300935. doi: 10.1371/journal.pone.0300935. eCollection 2024. PLoS One. 2024. PMID: 38517844 Free PMC article.
-
Early absorption sources of caffeine can be a useful strategy for improving female table tennis players-specific performance.J Int Soc Sports Nutr. 2023 Dec;20(1):2282051. doi: 10.1080/15502783.2023.2282051. Epub 2023 Nov 16. J Int Soc Sports Nutr. 2023. PMID: 37974406 Free PMC article. Clinical Trial.
-
Exploring brain functional connectivity in patients with taste loss: a pilot study.Eur Arch Otorhinolaryngol. 2023 Oct;280(10):4491-4499. doi: 10.1007/s00405-023-08019-4. Epub 2023 May 17. Eur Arch Otorhinolaryngol. 2023. PMID: 37198301 Free PMC article.
-
Brain activation in individuals suffering from bulimia nervosa and control subjects during sweet and sour taste stimuli.Front Psychiatry. 2023 Mar 2;14:1022537. doi: 10.3389/fpsyt.2023.1022537. eCollection 2023. Front Psychiatry. 2023. PMID: 36937709 Free PMC article.
-
Emotional modulation of cortical activity during gum chewing: A functional near-infrared spectroscopy study.Front Neurosci. 2022 Nov 29;16:964351. doi: 10.3389/fnins.2022.964351. eCollection 2022. Front Neurosci. 2022. PMID: 36523435 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources