Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
- PMID: 17018837
- DOI: 10.1210/er.2006-0037
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
Abstract
Many biological programs are regulated at the transcriptional level. This is generally achieved by the concerted actions of several transcription factors. Recent findings have shown that, in many cases, transcriptional coactivators coordinate the overall regulation of the biological programs. One of the best-studied examples of coactivator control of metabolic pathways is the peroxisome proliferator-activated receptor coactivator 1 (PGC-1) family. These proteins are strong activators of mitochondrial function and are thus dominant regulators of oxidative metabolism in a variety of tissues. The PGC-1 coactivators themselves are subject to powerful regulation at the transcriptional and posttranslational levels. Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration.
Similar articles
-
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer.Semin Cell Dev Biol. 2012 Jun;23(4):381-8. doi: 10.1016/j.semcdb.2012.01.007. Epub 2012 Jan 21. Semin Cell Dev Biol. 2012. PMID: 22285815 Free PMC article. Review.
-
PGC-1 coactivators in the control of energy metabolism.Acta Biochim Biophys Sin (Shanghai). 2011 Apr;43(4):248-57. doi: 10.1093/abbs/gmr007. Epub 2011 Feb 16. Acta Biochim Biophys Sin (Shanghai). 2011. PMID: 21325336 Free PMC article. Review.
-
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.Circulation. 2007 May 15;115(19):2540-8. doi: 10.1161/CIRCULATIONAHA.107.670588. Circulation. 2007. PMID: 17502589 No abstract available.
-
PGC-1alpha: a key regulator of energy metabolism.Adv Physiol Educ. 2006 Dec;30(4):145-51. doi: 10.1152/advan.00052.2006. Adv Physiol Educ. 2006. PMID: 17108241 Review.
-
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.Endocr Rev. 2003 Feb;24(1):78-90. doi: 10.1210/er.2002-0012. Endocr Rev. 2003. PMID: 12588810 Review.
Cited by
-
PGC-1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age-related macular degeneration.J Cell Mol Med. 2024 Apr;28(8):e18051. doi: 10.1111/jcmm.18051. J Cell Mol Med. 2024. PMID: 38571282 Free PMC article.
-
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004. Cell Stem Cell. 2024. PMID: 38458178
-
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases.Signal Transduct Target Ther. 2024 Mar 1;9(1):50. doi: 10.1038/s41392-024-01756-w. Signal Transduct Target Ther. 2024. PMID: 38424050 Free PMC article. Review.
-
PGC1-α in diabetic kidney disease: unraveling renoprotection and molecular mechanisms.Mol Biol Rep. 2024 Feb 15;51(1):304. doi: 10.1007/s11033-024-09232-y. Mol Biol Rep. 2024. PMID: 38361088 Review.
-
Naringin ameliorates obesity via stimulating adipose thermogenesis and browning, and modulating gut microbiota in diet-induced obese mice.Curr Res Food Sci. 2024 Jan 18;8:100683. doi: 10.1016/j.crfs.2024.100683. eCollection 2024. Curr Res Food Sci. 2024. PMID: 38313225 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources