Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;63(3):141-5.
doi: 10.1007/s11130-008-0083-y. Epub 2008 Jul 25.

Hepatic protection by noni fruit juice against CCl(4)-induced chronic liver damage in female SD rats

Mian-Ying Wang  1 , Gary Anderson, Diane Nowicki, Jarakae Jensen
Affiliations

Hepatic protection by noni fruit juice against CCl(4)-induced chronic liver damage in female SD rats

Mian-Ying Wang et al. Plant Foods Hum Nutr. 2008 Sep.

Abstract

Morinda citrifolia L. (noni) has been used throughout the Pacific, Southeast Asia, Central America, and the Caribbean for a variety of health conditions, including heart and liver ailments. In this study, we examined the hepatoprotective effects of TAHITIAN NONI Juice (TNJ) against CCl(4)-induced chronic liver damage in female Sprague Dawley (SD) rats. Twelve female SD rats were divided into control, placebo and TNJ (6 mL/rat/day) groups. On day 15, animals in the placebo and TNJ groups received 0.25 mL/kg CCl(4) in corn oil once a week for 12 successive weeks. All animals were sacrificed at week 16. Blood and liver were collected for liver function, lipid panel tests, and histological observation. Histopathological examination revealed that liver sections from the TNJ + CCl(4) appeared similar to controls, whereas typical hepatic steatosis was observed in the placebo + CCl(4) group. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels were increased in the placebo group compared with the TNJ group. In contrast, high-density lipoprotein (HDL) was increased in the TNJ group and decreased in the placebo group. Thus, TNJ juice appears to protect the liver from chronic exogenous CCl(4) exposures. Such protective mechanisms are supportive evidence for the utility of noni in traditional medicine for liver ailments.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Phytother Res. 2006 Nov;20(11):935-40 - PubMed
    1. Boll Soc Ital Biol Sper. 1954 Mar;30(3):164-6 - PubMed
    1. Gastroenterology. 1995 Jun;108(6):1849-54 - PubMed
    1. Semin Liver Dis. 1990 Nov;10(4):279-84 - PubMed
    1. Acta Pharmacol Sin. 2002 Dec;23(12):1127-41 - PubMed

Publication types

MeSH terms

LinkOut - more resources

-