Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh
- PMID: 23481591
- PMCID: PMC3709300
- DOI: 10.3390/ijerph10031006
Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh
Abstract
Ingestion of inorganic arsenic (iAs) is considered to be related to the development of diabetes mellitus. In order to clarify the possible differences in the metabolism in diabetics, we measured urinary iAs metabolites in diabetic cases and non-diabetic control subjects in Faridpur, an arsenic-contaminated area in Bangladesh. Physician-diagnosed type 2 diabetic cases (140 persons) and non-diabetic controls (180 persons) were recruited. Drinking water and spot urine samples were collected. Mean concentrations of total arsenic in drinking water did not differ between cases (85.1 μg/L) and controls (85.8 μg/L). The percentage of urinary iAs (iAs%) was significantly lower in cases (8.6%) than in controls (10.4%), while that of dimethylarsinic acid (DMA%) was higher in cases (82.6%) than in controls (79.9%). This may have been due to the higher secondary methylation index (SMI) in the former (11.6) rather than the latter (10.0). Adjusting for matching factors (sex and unions), and the additional other covariates (age and water arsenic) significantly attenuated the differences in iAs%, SMI, and DMA%, respectively, though the difference in monomethylarsonic acid% was newly significant in the latter adjustment. Our study did not suggest any significant differences in urinary arsenic metabolites between diabetic and non-diabetic subjects.
Similar articles
-
Arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh.Environ Health Prev Med. 2012 May;17(3):235-45. doi: 10.1007/s12199-011-0247-5. Epub 2011 Nov 3. Environ Health Prev Med. 2012. PMID: 22048870 Free PMC article.
-
Associations of arsenic metabolites, methylation capacity, and skin lesions caused by chronic exposure to high arsenic in tube well water.Environ Toxicol. 2017 Jan;32(1):28-36. doi: 10.1002/tox.22209. Epub 2015 Oct 23. Environ Toxicol. 2017. PMID: 26494561
-
Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions.Environ Sci Pollut Res Int. 2018 Aug;25(24):24394-24402. doi: 10.1007/s11356-018-2512-2. Epub 2018 Jun 15. Environ Sci Pollut Res Int. 2018. PMID: 29948723
-
Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China.Int J Environ Res Public Health. 2014 Jul 18;11(7):7319-32. doi: 10.3390/ijerph110707319. Int J Environ Res Public Health. 2014. PMID: 25046631 Free PMC article.
-
A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh.Environ Health Perspect. 2013 Jul;121(7):832-8. doi: 10.1289/ehp.1205797. Epub 2013 May 10. Environ Health Perspect. 2013. PMID: 23665672 Free PMC article.
Cited by
-
Arsenic exposure and measures of glucose tolerance in Bangladeshi adults: A cross-sectional study.Environ Epidemiol. 2024 Aug 21;8(5):e330. doi: 10.1097/EE9.0000000000000330. eCollection 2024 Oct. Environ Epidemiol. 2024. PMID: 39175802 Free PMC article.
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Arsenic in Drinking Water and Diabetes.Water (Basel). 2023 May 1;15(9):1751. doi: 10.3390/w15091751. Epub 2023 May 2. Water (Basel). 2023. PMID: 37886432 Free PMC article.
-
Effects of Dietary Intake of Arsenosugars and Other Organic Arsenic Species on Studies of Arsenic Methylation Efficiency in Humans.Environ Health (Wash). 2023 Sep 21;1(4):236-248. doi: 10.1021/envhealth.3c00090. eCollection 2023 Oct 20. Environ Health (Wash). 2023. PMID: 37881591 Free PMC article. Review.
-
Arsenic metabolism, diabetes prevalence, and insulin resistance among Mexican Americans: A mendelian randomization approach.Environ Adv. 2023 Jul;12:100361. doi: 10.1016/j.envadv.2023.100361. Epub 2023 Mar 24. Environ Adv. 2023. PMID: 37426694 Free PMC article.
References
-
- Arsenic in Drinking Water. Background Document for Preparation of WHO Guidelines for Drinking-Water Quality. World Health Organization; Geneva, Switzerland: 2003.
-
- Smedley P.L., Kinniburg D.G. A review of the source, behavior and distribution of arsenic in natural waters. Appl. Geochem. 2002;17:517–568. doi: 10.1016/S0883-2927(02)00018-5. - DOI
-
- Kinniburgh D.G., Smedley P.L. Arsenic Contamination of Groundwater in Bangladesh. British Geological Survey (BGS),Department for International Development (DFID),Government of the People’s Republic of Bangladesh, Ministry of Local Government, Rural Development and Cooperatives, Department of Public Health Engineering (DPHE); Dhaka, Bangladesh: 2001.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical