Inverse association between toenail arsenic and body mass index in a population of welders

doi:10.1016/j.envres.2014.03.010

. 2014 May:131:131-3.

doi: 10.1016/j.envres.2014.03.010. Epub 2014 Apr 9.

Inverse association between toenail arsenic and body mass index in a population of welders

Rachel Grashow¹, Jinming Zhang², Shona C Fang³, Marc G Weisskopf⁴, David C Christiani⁴, Molly L Kile⁵, Jennifer M Cavallari⁶

Affiliations

¹ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA. Electronic address: rgrashow@hsph.harvard.edu.
² Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA.
³ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; New England Research Institutes, Watertown, MA, USA.
⁴ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
⁵ Department of Public Health, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
⁶ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; Division of Occupational and Environmental Medicine, University of Connecticut Health Center, Farmington, CT, USA.

PMID: 24721130
PMCID: PMC4035809
DOI: 10.1016/j.envres.2014.03.010

Inverse association between toenail arsenic and body mass index in a population of welders

Rachel Grashow et al. Environ Res. 2014 May.

. 2014 May:131:131-3.

doi: 10.1016/j.envres.2014.03.010. Epub 2014 Apr 9.

Authors

Rachel Grashow¹, Jinming Zhang², Shona C Fang³, Marc G Weisskopf⁴, David C Christiani⁴, Molly L Kile⁵, Jennifer M Cavallari⁶

Affiliations

¹ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA. Electronic address: rgrashow@hsph.harvard.edu.
² Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA.
³ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; New England Research Institutes, Watertown, MA, USA.
⁴ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
⁵ Department of Public Health, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
⁶ Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215, USA; Division of Occupational and Environmental Medicine, University of Connecticut Health Center, Farmington, CT, USA.

PMID: 24721130
PMCID: PMC4035809
DOI: 10.1016/j.envres.2014.03.010

Abstract

Recent data show that arsenic may play a role in obesity-related diseases. However, urinary arsenic studies report an inverse association between arsenic level and body mass index (BMI). We explored whether toenail arsenic, a long-term exposure measure, was associated with BMI in 74 welders with known arsenic exposure. BMI showed significant inverse associations with toenail arsenic (p=0.01), which persisted in models adjusted for demographics, diet and work history. It is unclear whether low arsenic biomarker concentrations in high BMI subjects truly reflect lower exposures, or instead reflect internal or metabolic changes that alter arsenic metabolism and tissue deposition.

Keywords: Arsenic; BMI; Metals; Occupational health; Toenail; Welding fume.

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References

1. Brochu P, et al. Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly. Risk Anal 2013 - PubMed
1. Chen CJ, et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol. 2005;206:198–206. - PubMed
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1. Gruber JF, et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutr J. 2012;11:45. - PMC - PubMed

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[1] Brochu P, et al. Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly. Risk Anal 2013 - PubMed

[2] Brochu P, et al. Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly. Risk Anal 2013 - PubMed

[3] Chen CJ, et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol. 2005;206:198–206. - PubMed

[4] Chen CJ, et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol. 2005;206:198–206. - PubMed

[5] Gomez-Rubio P, et al. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol. 2011;252:176–82. - PMC - PubMed

[6] Gomez-Rubio P, et al. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol. 2011;252:176–82. - PMC - PubMed

[7] Grashow R, et al. Toenail metal concentration as a biomarker of occupational welding fume exposure. J Occup Environ Hyg. 2013 Epub ahead of print. - PMC - PubMed

[8] Grashow R, et al. Toenail metal concentration as a biomarker of occupational welding fume exposure. J Occup Environ Hyg. 2013 Epub ahead of print. - PMC - PubMed

[9] Gruber JF, et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutr J. 2012;11:45. - PMC - PubMed

[10] Gruber JF, et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutr J. 2012;11:45. - PMC - PubMed

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Inverse association between toenail arsenic and body mass index in a population of welders

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Inverse association between toenail arsenic and body mass index in a population of welders

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