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Review
. 2014 Aug;20(8):460-9.
doi: 10.1016/j.molmed.2014.06.005. Epub 2014 Jul 12.

MicroRNAs in cancer: biomarkers, functions and therapy

Josie Hayes  1 , Pier Paolo Peruzzi  2 , Sean Lawler  3
Affiliations
Review

MicroRNAs in cancer: biomarkers, functions and therapy

Josie Hayes et al. Trends Mol Med. 2014 Aug.

Abstract

The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.

Keywords: cancer; clinical; microRNA; prognosis; signature.

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