MicroRNAs
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Year introduced: 2003
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Subheadings:
Tree Number(s): D13.150.650.319, D13.444.735.150.319, D13.444.735.790.552.500
MeSH Unique ID: D035683
Entry Terms:
- Micro RNA
- RNA, Micro
- MicroRNA
- miRNA
- miRNAs
- RNA, Small Temporal
- Temporal RNA, Small
- Small Temporal RNA
- stRNA
- Primary MicroRNA
- MicroRNA, Primary
- pri-miRNA
- pri miRNA
- Primary miRNA
- miRNA, Primary
- pre-miRNA
- pre miRNA
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