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. 2015 Feb 1;8(2):1967-72.
eCollection 2015.

Down-regulation of microRNA-124 is correlated with tumor metastasis and poor prognosis in patients with lung cancer

Yajun Zhang  1 , Hongbing Li  1 , Jichang Han  1 , Yijie Zhang  1
Affiliations

Down-regulation of microRNA-124 is correlated with tumor metastasis and poor prognosis in patients with lung cancer

Yajun Zhang et al. Int J Clin Exp Pathol. .

Abstract

Introduction: MicroRNA-124 (miR-124) has been proven dysregulated in several human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to investigate the clinical significance of miR-124 expression in NSCLC.

Methods: Expression levels of miR-124 in 92 pairs of NSCLC and adjacent non-tumor tissues were detected by quantitative real-time PCR (qRT-PCR). In order to determine its prognostic value, overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis.

Results: miR-124 expression level was significantly lower in NSCLC tissues compared with adjacent non-tumor tissues (P < 0.05). The 5-year OS of low miR-124 expression group was significantly shorter than that of high miR-124 expression group (P < 0.05). Moreover, the 5-year DFS of low miR-124 expression group was also significantly shorter than that of high miR-124 expression group (P < 0.05). In a multivariate Cox model, we found that miR-124 expression was an independent prognostic factor for both 5-year OS and 5-year DFS in NSCLC (P < 0.05).

Conclusions: Our results offer the convincing evidence that miR-124 may play key roles in the progression of lung cancer and that the down-regulated expression of miR-124 may be independently associated with shorter OS and DFS of patients, suggesting that miR-124 might be a potential marker for further risk stratification in the treatment of lung cancer.

Keywords: Non-small cell lung cancer; disease-free survival; miR-124; overall survival.

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Figures

Figure 1
Figure 1
MiR-124 expression in 92 pairs of clinical NSCLC and adjacent non-tumor tissues were detected by qRT-PCR. After normalization to U6 expression levels, the expression level of miR-124 in NSCLC tissues was significantly lower than that in non-tumor tissues. *P < 0.05.
Figure 2
Figure 2
Kaplan-Meier curves for survival time in patients with NSCLC divided according to miR-124 expression. Overall survival and disease-free survival of patients with low vs. high miR-124 expression levels are shown. A. Overall survival rate of NSCLC patients with low miR-124 was significantly shorter compared to those patients with high miR-124 (P < 0.05). B. Disease-free survival rate of NSCLC patients with low miR-124 was significantly shorter compared to those patients with high miR-124 (P < 0.05).
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