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Review
. 2017 May 1:8:760.
doi: 10.3389/fmicb.2017.00760. eCollection 2017.

Deep Sea Actinomycetes and Their Secondary Metabolites

Manita Kamjam  1 , Periyasamy Sivalingam  1 , Zinxin Deng  1 , Kui Hong  1
Affiliations
Review

Deep Sea Actinomycetes and Their Secondary Metabolites

Manita Kamjam et al. Front Microbiol. .

Abstract

Deep sea is a unique and extreme environment. It is a hot spot for hunting marine actinomycetes resources and secondary metabolites. The novel deep sea actinomycete species reported from 2006 to 2016 including 21 species under 13 genera with the maximum number from Microbacterium, followed by Dermacoccus, Streptomyces and Verrucosispora, and one novel species for the other 9 genera. Eight genera of actinomycetes were reported to produce secondary metabolites, among which Streptomyces is the richest producer. Most of the compounds produced by the deep sea actinomycetes presented antimicrobial and anti-cancer cell activities. Gene clusters related to biosynthesis of desotamide, heronamide, and lobophorin have been identified from the deep sea derived Streptomyces.

Keywords: actinomycetes; bioactive natural products; biosynthesis; deep sea; novel species.

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References

    1. Abdel-Mageed W. M., Milne B. F., Wagner M., Schumacher M., Sandor P., Pathom-aree W., et al. . (2010). Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment. Org. Biomol. Chem. 8, 2352–2362. 10.1039/c001445a - DOI - PubMed
    1. Azman A. S., Othman I., Velu S. S., Cha K. G., Lee L. H. (2015). Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity. Front. Microbiol. 6:856. 10.3389/fmicb.2015.00856 - DOI - PMC - PubMed
    1. Berdy J. (2012). Thoughts and facts about antibiotics: where we are now and where we are heading. J. Antibiot. 65, 385–395. 10.1038/ja.2012.27 - DOI - PubMed
    1. Bhadra B., Raghukumar C., Pindi P. K., Shivaji S. (2008). Brevibacterium oceani sp. nov., isolated from deep-sea sediment of the Chagos Trench, Indian ocean. Int. J. Syst. Evol. Microbiol. 58, 57–60. 10.1099/ijs.0.64869-0 - DOI - PubMed
    1. Bian J., Li Y., Wang J., Song F. H., Liu M., Dai H. Q., et al. . (2009). Amycolatopsis marina sp. nov., an actinomycete isolated from an ocean sediment. Int. J. Syst. Evol. Microbiol. 59, 477–481. 10.1099/ijs.0.000026-0 - DOI - PubMed

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