Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction
- PMID: 28587078
- PMCID: PMC5490519
- DOI: 10.3390/nu9060540
Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction
Abstract
Cultural and economic shifts in the early 19th century led to the rapid development of companies that made good profits from technologically-produced commodities. In this way, some habits changed in society, such as the overconsumption of processed and micronutrient-poor foods and devices that gave rise to a sedentary lifestyle. These factors influenced host-microbiome interactions which, in turn, mediated the etiopathogenesis of "new-era" disorders and diseases, which are closely related, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, and inflammatory bowel disease, which are characterized by chronic dysregulation of metabolic and immune processes. These pathological conditions require novel and effective therapeutic approaches. Morindacitrifolia (noni) is well known as a traditional healing plant due to its medicinal properties. Thus, many studies have been conducted to understand its bioactive compounds and their mechanisms of action. However, in obesity and obesity-related metabolic (dysfunction) syndrome, other studies are necessary to better elucidate noni's mechanisms of action, mainly due to the complexity of the pathophysiology of obesity and its metabolic dysfunction. In this review, we summarize not only the clinical effects, but also important cell signaling pathways in in vivo and in vitro assays of potent bioactive compounds present in the noni plant which have been reported in studies of obesity and obesity-associated metabolic dysfunction.
Keywords: Morinda citrifolia L.; health; obesity; obesity-related metabolic dysfunction.
Conflict of interest statement
The authors report no conflict of interest.
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References
-
- World Health Organization Obesity and Overweight. [(accessed on 12 November 2016)]; Available online: http://www.who.int/mediacentre/factsheets/fs311/en/
-
- World Health Organization Regional Office for Europe. [(accessed on 12 November 2016)]; Available online: http://www.euro.who.int/__data/assets/pdf_file/0003/294474/European-Food....
-
- World Health Organization Obesity and Diabetes: The Slow-Motion Disaster Keynote Address at the 47th Meeting of the National Academy of Medicine. [(accessed on 12 November 2016)]; Available online: http://www.who.int/dg/speeches/2016/obesity-diabetes-disaster/en/
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