In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra

doi:10.1016/j.foodchem.2011.04.098

. 2011 Nov 15;129(2):454-462.

doi: 10.1016/j.foodchem.2011.04.098. Epub 2011 May 6.

In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra

Juliana Vinholes¹, Clara Grosso¹, Paula B Andrade², Angel Gil-Izquierdo³, Patrícia Valentão¹, Paula Guedes de Pinho⁴, Federico Ferreres⁵

Affiliations

¹ REQUIMTE/Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal.
² REQUIMTE/Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal. Electronic address: pandrade@ff.up.pt.
³ Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain.
⁴ REQUIMTE/Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal.
⁵ Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. Electronic address: federico@cebas.csic.es.

PMID: 30634251
DOI: 10.1016/j.foodchem.2011.04.098

In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra

Juliana Vinholes et al. Food Chem. 2011.

. 2011 Nov 15;129(2):454-462.

doi: 10.1016/j.foodchem.2011.04.098. Epub 2011 May 6.

Authors

Juliana Vinholes¹, Clara Grosso¹, Paula B Andrade², Angel Gil-Izquierdo³, Patrícia Valentão¹, Paula Guedes de Pinho⁴, Federico Ferreres⁵

Affiliations

¹ REQUIMTE/Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal.
² REQUIMTE/Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal. Electronic address: pandrade@ff.up.pt.
³ Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain.
⁴ REQUIMTE/Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, R. Aníbal Cunha, 164, 4050-047 Porto, Portugal.
⁵ Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. Electronic address: federico@cebas.csic.es.

PMID: 30634251
DOI: 10.1016/j.foodchem.2011.04.098

Abstract

Spergularia rubra is distributed all over the world, being its infusion used as diuretic. In spite of its large use, the antidiabetic, anti-cholinesterase and antioxidant activities of this species have not been assessed and its chemical composition is scarcely known. In the work herein a hydromethanolic extract was studied. Thirty-six phenolic compounds were determined by HPLC-DAD, comprising non-acylated C-glycosyl flavones (38%), C-glycosyl flavones acylated with aromatic acids (36%), C-glycosyl flavones acylated with aliphatic acids (13%) and 10% corresponded to C-glycosyl flavones with a mixed acylation. Organic acids (oxalic, citric, malic, quinic and fumaric acids) and fatty acids (azelaic, myristic, palmitic, linoleic, linolenic and stearic acids) are described for the first time. Their determination by HPLC-UV and GC-IT-MS allowed finding concentrations of 192.15 and 34.87g/kg, respectively. The extract showed a dose-dependent response against DPPH, superoxide and nitric oxide radicals. The same effect was observed in the α-glucosidase inhibitory assay and against acetylcholinesterase and butyrylcholinesterases. The bioactivities observed may be due, at least partially, to the presence of the different metabolites determined in the present study. The results suggest that the dried extract of S. rubra may be interesting for incorporation in pharmaceutical preparations for human health, since it can suppress hyperglycaemia and inhibit cholinesterases, and or as food additive due to its antiradical activity.

Keywords: Antioxidant activity; Cholinesterases inhibition; Metabolic profile; Spergularia rubra; α-Glucosidase inhibition.

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In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra

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In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra

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