Associations between the Nutrient Profiling System Underlying the Nutri-Score Nutrition Label and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis of a Middle- to Older-Aged Population
- PMID: 35956304
- PMCID: PMC9370507
- DOI: 10.3390/nu14153122
Associations between the Nutrient Profiling System Underlying the Nutri-Score Nutrition Label and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis of a Middle- to Older-Aged Population
Abstract
Low-grade systemic inflammation is associated with a range of conditions. Diet may modulate inflammation and public health strategies are needed to guide consumers' dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study to date has examined FSAm-NPS dietary index associations with biomarkers of inflammation. Therefore, our objective was to test relationships between the FSAm-NPS and a range of inflammatory biomarkers in a cross-sectional sample of 2006 men and women aged 46-73 years. Individual participant FSAm-NPS scores were derived from food frequency questionnaires. Pro-inflammatory cytokine, adipocytokine, acute-phase response protein, coagulation factor and white blood cell count concentrations were determined. Correlation and linear regression analyses were used to examine FSAm-NPS relationships with biomarker levels. In crude and adjusted analyses, higher FSAm-NPS scores, reflecting poorer nutritional quality, were consistently and positively associated with biomarkers. In fully adjusted models, significant associations with concentrations of complement component 3, c-reactive protein, interleukin 6, tumour necrosis factor alpha, resistin, white blood cell count, neutrophils, eosinophils and the neutrophil-to-lymphocyte ratio persisted. These results suggest that dietary quality, determined by Nutri-Score rating, is associated with inflammatory biomarkers related to health.
Keywords: biomarkers; chronic; diet; inflammation; nutri-score.
Conflict of interest statement
The authors declare no conflict of interest.
Similar articles
-
Association between the nutrient profile system underpinning the Nutri-Score front-of-pack nutrition label and mortality in the SUN project: A prospective cohort study.Clin Nutr. 2021 Mar;40(3):1085-1094. doi: 10.1016/j.clnu.2020.07.008. Epub 2020 Jul 17. Clin Nutr. 2021. PMID: 32768318
-
Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries.BMJ. 2020 Sep 16;370:m3173. doi: 10.1136/bmj.m3173. BMJ. 2020. PMID: 32938660 Free PMC article.
-
Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study.PLoS Med. 2018 Sep 18;15(9):e1002651. doi: 10.1371/journal.pmed.1002651. eCollection 2018 Sep. PLoS Med. 2018. PMID: 30226842 Free PMC article.
-
International evidence for the effectiveness of the front-of-package nutrition label called Nutri-Score.Cent Eur J Public Health. 2021 Mar;29(1):76-79. doi: 10.21101/cejph.a6239. Cent Eur J Public Health. 2021. PMID: 33831290 Review.
-
Nutri-Score 2023 update.Nat Food. 2024 Feb;5(2):102-110. doi: 10.1038/s43016-024-00920-3. Epub 2024 Feb 14. Nat Food. 2024. PMID: 38356074 Review.
Cited by
-
Associations of Systematic Inflammatory Markers with Diet Quality, Blood Pressure, and Obesity in the AIRWAVE Health Monitoring Study.J Inflamm Res. 2024 May 18;17:3129-3141. doi: 10.2147/JIR.S459238. eCollection 2024. J Inflamm Res. 2024. PMID: 38784102 Free PMC article.
-
Lifestyle factors and BMI attenuate relationships between biomarkers of inflammation and depressive symptoms and well-being: A cross-sectional study.Brain Behav Immun Health. 2024 Mar 18;37:100759. doi: 10.1016/j.bbih.2024.100759. eCollection 2024 May. Brain Behav Immun Health. 2024. PMID: 38560580 Free PMC article.
-
A Little Bird Told Me… Nutri-Score Panoramas from a Flight over Europe, Connecting Science and Society.Nutrients. 2023 Jul 28;15(15):3367. doi: 10.3390/nu15153367. Nutrients. 2023. PMID: 37571304 Free PMC article.
-
Food Compass Score and its association with inflammatory markers and homocysteine in cardiovascular disease-free adults: a cross-sectional analysis of the ATTICA epidemiological study.Eur J Clin Nutr. 2023 Oct;77(10):998-1004. doi: 10.1038/s41430-023-01300-z. Epub 2023 Jul 3. Eur J Clin Nutr. 2023. PMID: 37400562
References
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials