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. 1986 Nov;30(8):625-9.
doi: 10.1111/j.1399-6576.1986.tb02488.x.

Effects of repeated bupivacaine administration on sciatic nerve and surrounding muscle tissue in rats

J Kyttä, E Heinonen, P H Rosenberg, T Wahlström, J Gripenberg, T Huopaniemi

Effects of repeated bupivacaine administration on sciatic nerve and surrounding muscle tissue in rats

J Kyttä et al. Acta Anaesthesiol Scand. 1986 Nov.

Abstract

The effects of repeated administration of 0.5% bupivacaine or saline into the sciatic notch of rats were studied by light microscopy, electron microscopy and a neurophysiological technique. Very severe myositis, including local necrosis, developed in six of 12 rats treated twice daily with 1 ml bupivacaine for either 3 or 7 days. A 3-h infusion of 1.5 ml 0.5% bupivacaine resulted in minor injury to muscle tissue. A marked degree of disruption and vacuolization of myelin sheaths was evident in nerves exposed to bupivacaine for 3 days. Lymphocyte accumulation was confined to the area surrounding the nervous tissue in 7 of 10 of the preparations from rats treated for 3 days or by a 3-h infusion. No histological changes were detected in nerve and muscle tissue from the opposite extremity exposed to saline. After a recovery period of 3 weeks, no differences in the nerve or muscle histology were seen between samples from bupivacaine- or saline-treated animals. The amplitude of the compound action potential of sciatic nerves was, however, significantly lower after bupivacaine treatment (7 days, 1 ml twice daily). Thus, impaired function may continue despite the lack of histological intraneural injury.

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