Ingested inorganic arsenic and prevalence of diabetes mellitus
- PMID: 8154472
- DOI: 10.1093/oxfordjournals.aje.a117031
Ingested inorganic arsenic and prevalence of diabetes mellitus
Abstract
To examine the association between ingested inorganic arsenic and prevalence of diabetes mellitus, in 1988, the authors studied 891 adults residing in villages in southern Taiwan where arseniasis is hyperendemic. The status of diabetes mellitus was determined by an oral glucose tolerance test and a history of diabetes regularly treated with sulfonylurea or insulin. The cumulative arsenic exposure in parts per million-years was calculated from the detailed history of residential addresses and duration of drinking artesian well water obtained through standardized interviews based on a structured questionnaire and the arsenic concentration in well water. The body mass index was derived from body height and weight measured according to a standard protocol, while the physical activity at work was also obtained by questionnaire interviews. Residents in villages where the chronic arseniasis was hyperendemic had a twofold increase in age- and sex-adjusted prevalence of diabetes mellitus compared with residents in Taipei City and the Taiwan area. There was a dose-response relation between cumulative arsenic exposure and prevalence of diabetes mellitus. The relation remained significant after adjustment for age, sex, body mass index, and activity level at work by a multiple logistic regression analysis giving a multivariate-adjusted odds ratio of 6.61 and 10.05, respectively, for those who had a cumulative arsenic exposure of 0.1-15.0 and greater than 15.0 ppm-year compared with those who were unexposed. These results suggest the chronic arsenic exposure may induce diabetes mellitus in humans.
Similar articles
-
Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan.Angiology. 1997 Apr;48(4):321-35. doi: 10.1177/000331979704800405. Angiology. 1997. PMID: 9112880
-
Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.Atherosclerosis. 1996 Feb;120(1-2):125-33. doi: 10.1016/0021-9150(95)05693-9. Atherosclerosis. 1996. PMID: 8645353
-
Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan.J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Oct;42(12):1843-51. doi: 10.1080/10934520701566884. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007. PMID: 17952785
-
Epidemiologic evidence of diabetogenic effect of arsenic.Toxicol Lett. 2002 Jul 7;133(1):69-76. doi: 10.1016/s0378-4274(02)00085-1. Toxicol Lett. 2002. PMID: 12076511 Review.
-
Arsenic and diabetes: current perspectives.Kaohsiung J Med Sci. 2011 Sep;27(9):402-10. doi: 10.1016/j.kjms.2011.05.008. Epub 2011 Jul 6. Kaohsiung J Med Sci. 2011. PMID: 21914528 Review.
Cited by
-
Research progress on arsenic, arsenic-containing medicinal materials, and arsenic-containing preparations: clinical application, pharmacological effects, and toxicity.Front Pharmacol. 2024 Mar 1;15:1338725. doi: 10.3389/fphar.2024.1338725. eCollection 2024. Front Pharmacol. 2024. PMID: 38495096 Free PMC article. Review.
-
Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk.Toxicol Appl Pharmacol. 2024 Jan;482:116768. doi: 10.1016/j.taap.2023.116768. Epub 2023 Nov 27. Toxicol Appl Pharmacol. 2024. PMID: 38030093
-
Arsenic in Drinking Water and Diabetes.Water (Basel). 2023 May 1;15(9):1751. doi: 10.3390/w15091751. Epub 2023 May 2. Water (Basel). 2023. PMID: 37886432 Free PMC article.
-
Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic.Nutrients. 2021 Aug 23;13(8):2894. doi: 10.3390/nu13082894. Nutrients. 2021. PMID: 34445052 Free PMC article.
-
Arsenic Exposure, Arsenic Metabolism, and Glycemia: Results from a Clinical Population in New York City.Int J Environ Res Public Health. 2021 Apr 3;18(7):3749. doi: 10.3390/ijerph18073749. Int J Environ Res Public Health. 2021. PMID: 33916749 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical