A case of spinal cord injury-related pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentin
- PMID: 9839825
- DOI: 10.1016/S0304-3959(98)00153-5
A case of spinal cord injury-related pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentin
Abstract
Central pain following spinal cord injury is poorly understood, and is often resistant to conventional pain therapy regimens. We describe an individual with paraplegia who for many years experienced rapidly fluctuating, severe, unilateral pain below the level of his lesion. Prior to the initiation of pharmacological treatment, regional cerebral blood flow (rCBF) was measured during PAIN and NON-PAIN states using single photon emission computed tomography (SPECT). When experiencing pain, the subject had increased anterior cingulate gyrus blood flow, increased thalamic blood flow bilaterally and increased somatosensory cortex blood flow contralaterally but decreased caudate blood flow bilaterally. The subject's subsequent clinical course included a trial of gabapentin which produced a substantial reduction in frequency and average intensity of his episodic pain and which has been maintained for almost 2 years. This case demonstrates the correspondence between rCBF and pain associated with spinal cord injury and also suggests the potential utility of gabapentin for treatment of this central pain state.
Similar articles
-
Gabapentin effect on neuropathic pain compared among patients with spinal cord injury and different durations of symptoms.Spine (Phila Pa 1976). 2003 Feb 15;28(4):341-6; discussion 346-7. doi: 10.1097/01.BRS.0000048464.57011.00. Spine (Phila Pa 1976). 2003. PMID: 12590206 Clinical Trial.
-
Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury.Spine (Phila Pa 1976). 2004 Apr 1;29(7):743-51. doi: 10.1097/01.brs.0000112068.16108.3a. Spine (Phila Pa 1976). 2004. PMID: 15087796 Clinical Trial.
-
Beneficial response to gabapentin portraying with interval change of brain SPECT imaging in a case with failed back surgery syndrome.J Clin Pharm Ther. 2011 Aug;36(4):525-8. doi: 10.1111/j.1365-2710.2010.01200.x. Epub 2010 Oct 19. J Clin Pharm Ther. 2011. PMID: 21729117
-
Gabapentin in pain management.Anesth Analg. 2000 Sep;91(3):680-7. doi: 10.1097/00000539-200009000-00034. Anesth Analg. 2000. PMID: 10960399 Review. No abstract available.
-
Interstitial cystitis and the potential role of gabapentin.South Med J. 2000 Feb;93(2):238-42. South Med J. 2000. PMID: 10701800 Review.
Cited by
-
Immediate effect of neurofeedback training on the pain matrix and cortical areas involved in processing neuropsychological functions.Neurol Sci. 2021 Nov;42(11):4551-4561. doi: 10.1007/s10072-021-05125-1. Epub 2021 Feb 23. Neurol Sci. 2021. PMID: 33624179
-
Modelling at-level allodynia after mid-thoracic contusion in the rat.Eur J Pain. 2021 Apr;25(4):801-816. doi: 10.1002/ejp.1711. Epub 2021 Jan 25. Eur J Pain. 2021. PMID: 33296535 Free PMC article.
-
Differences in neuroplasticity after spinal cord injury in varying animal models and humans.Neural Regen Res. 2019 Jan;14(1):7-19. doi: 10.4103/1673-5374.243694. Neural Regen Res. 2019. PMID: 30531063 Free PMC article. Review.
-
Cortical reorganization after spinal cord injury: always for good?Neuroscience. 2014 Dec 26;283:78-94. doi: 10.1016/j.neuroscience.2014.06.056. Epub 2014 Jul 2. Neuroscience. 2014. PMID: 24997269 Free PMC article. Review.
-
Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury.Pain. 2014 May;155(5):1027-1036. doi: 10.1016/j.pain.2014.02.008. Epub 2014 Feb 14. Pain. 2014. PMID: 24530612 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical