Biofabrication and 3D Tissue Modeling
3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine.
Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.
Biofabrication and 3D Tissue Modeling, The Royal Society of Chemistry, 2019.
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Chapter 1: Microstereolithographyp1-21ByShangting You;Shangting YouDepartment of NanoEngineering, University of CaliforniaSan Diego, La JollaCA 92093USAchen168@eng.ucsd.eduSearch for other works by this author on:Kathleen Miller;Kathleen MillerDepartment of NanoEngineering, University of CaliforniaSan Diego, La JollaCA 92093USAchen168@eng.ucsd.eduSearch for other works by this author on:Shaochen ChenShaochen ChenDepartment of NanoEngineering, University of CaliforniaSan Diego, La JollaCA 92093USAchen168@eng.ucsd.eduSearch for other works by this author on:
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Chapter 2: Extrusion-based Bioprintingp22-48ByMitchell Kuss;Mitchell KussMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center985965 Nebraska Medical CtrOmahaNE 68198-5965USAbin.duan@unmc.eduDivision of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center42nd and EmileOmahaNE 68198USASearch for other works by this author on:Bin DuanBin DuanMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center985965 Nebraska Medical CtrOmahaNE 68198-5965USAbin.duan@unmc.eduDivision of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center42nd and EmileOmahaNE 68198USADepartment of Surgery, College of Medicine, University of Nebraska Medical CenterOmahaNEUSASearch for other works by this author on:
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Chapter 3: Microfluidic Platforms for Biofabrication and 3D Tissue Modelingp49-76ByShoji TakeuchiShoji TakeuchiSearch for other works by this author on:
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Chapter 4: Computational Design and Modeling of Linear and Nonlinear Elastic Tissue Engineering Scaffold Triply Periodic Minimal Surface (TPMS) Porous Architecturep77-93ByS. J. HollisterS. J. HollisterCenter for 3D Medical Fabrication, Georgia Institute of TechnologyUSAscott.hollister@bme.gatech.eduhttp://3dmedfab.gatech.eduTissue Engineering & Mechanics Laboratory, Georgia Institute of TechnologyUSAhttp://temlab.gatech.edu/Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityUSASearch for other works by this author on:
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Chapter 5: Shear Thinning Hydrogel-based 3D Tissue Modellingp94-118BySarah C. HeilshornSarah C. HeilshornSearch for other works by this author on:
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Chapter 6: Polymers in Biofabrication and 3D Tissue Modellingp119-147ByFerry P. W. MelchelsFerry P. W. MelchelsHeriot-Watt University, Institute of Biological Chemistry, Biophysics and Bioengineering, Edinburgh CampusEH14 4AS, EdinburghUKf.melchels@hw.ac.ukSearch for other works by this author on:
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Chapter 7: Decellularized Tissue Matrix-based 3D Tissue Modelingp148-170BySanskrita Das;Sanskrita DasPohang University of Science and Technology, Department of Creative IT EngineeringPohang 37673Republic of Koreajinahjang@postech.ac.krSearch for other works by this author on:Ge Gao;Ge GaoPohang University of Science and Technology, Department of Mechanical EngineeringPohang 37673Republic of Koreadwcho@postech.ac.krSearch for other works by this author on:Jae Yeon Lee;Jae Yeon LeePohang University of Science and Technology, Department of Mechanical EngineeringPohang 37673Republic of Koreadwcho@postech.ac.krSearch for other works by this author on:Jinah Jang;Jinah JangPohang University of Science and Technology, Department of Creative IT EngineeringPohang 37673Republic of Koreajinahjang@postech.ac.krSearch for other works by this author on:Dong-Woo ChoDong-Woo ChoPohang University of Science and Technology, Department of Mechanical EngineeringPohang 37673Republic of Koreadwcho@postech.ac.krSearch for other works by this author on:
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Chapter 8: 3D Tissue Modelling of the Central Nervous Systemp171-183BySeokyoung Bang;Seokyoung BangDivision of WCU (World Class University) Multiscale Mechanical Design, School of Mechanical and Aerospace Engineering, Seoul National UniversitySeoul 08826South Koreanjeon@snu.ac.krSearch for other works by this author on:Seung-Ryeol Lee;Seung-Ryeol LeeDivision of WCU (World Class University) Multiscale Mechanical Design, School of Mechanical and Aerospace Engineering, Seoul National UniversitySeoul 08826South Koreanjeon@snu.ac.krSearch for other works by this author on:Noo Li JeonNoo Li JeonDivision of WCU (World Class University) Multiscale Mechanical Design, School of Mechanical and Aerospace Engineering, Seoul National UniversitySeoul 08826South Koreanjeon@snu.ac.krInstitute of Advanced Machinery and Design, Seoul National UniversitySeoul 08826South KoreaSearch for other works by this author on:
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Chapter 9: 3D Tissue Modelling of Skeletal Muscle Tissuep184-215ByMarco Costantini;Marco CostantiniFaculty of Material Science and Engineering, Warsaw University of Technology141 Woloska str.02-507, WarsawPolandwswieszk@inmat.pw.edu.plInstitute of Physical Chemistry, Polish Academy of Sciences01224 WarsawPolandSearch for other works by this author on:Stefano Testa;Stefano TestaDepartment of Biology, Tor Vergata Rome UniversityRomeItalySearch for other works by this author on:Chiara Rinoldi;Chiara RinoldiFaculty of Material Science and Engineering, Warsaw University of Technology141 Woloska str.02-507, WarsawPolandwswieszk@inmat.pw.edu.plSearch for other works by this author on:Nehar Celikkin;Nehar CelikkinFaculty of Material Science and Engineering, Warsaw University of Technology141 Woloska str.02-507, WarsawPolandwswieszk@inmat.pw.edu.plSearch for other works by this author on:Joanna Idaszek;Joanna IdaszekFaculty of Material Science and Engineering, Warsaw University of Technology141 Woloska str.02-507, WarsawPolandwswieszk@inmat.pw.edu.plSearch for other works by this author on:Cristina Colosi;Cristina ColosiItalian Institute of Technology (IIT), Center for Life Nano ScienceRomeItalySearch for other works by this author on:Andrea Barbetta;Andrea BarbettaDepartment of Chemistry, Sapienza University of Rome00185 RomeItalySearch for other works by this author on:Cesare Gargioli;Cesare GargioliDepartment of Biology, Tor Vergata Rome UniversityRomeItalySearch for other works by this author on:Wojciech ŚwięszkowskiWojciech ŚwięszkowskiFaculty of Material Science and Engineering, Warsaw University of Technology141 Woloska str.02-507, WarsawPolandwswieszk@inmat.pw.edu.plSearch for other works by this author on:
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Chapter 10: 3D Tissue Modelling of Orthopaedic Tissuesp216-232ByRamya Bojedla;Ramya BojedlaDepartment of Biomedical Engineering, Indian Institute Technology HyderabadKandi, Sangareddy – 502285TelanganaIndiafalguni@iith.ac.inSearch for other works by this author on:Shibu Chameettachal;Shibu ChameettachalDepartment of Biomedical Engineering, Indian Institute Technology HyderabadKandi, Sangareddy – 502285TelanganaIndiafalguni@iith.ac.inSearch for other works by this author on:Falguni PatiFalguni PatiDepartment of Biomedical Engineering, Indian Institute Technology HyderabadKandi, Sangareddy – 502285TelanganaIndiafalguni@iith.ac.inSearch for other works by this author on:
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Chapter 11: 3D Tissue Modeling of Skin Tissuep233-252ByJun-ho Heo;Jun-ho HeoUlsan National Institute of Science and Technology, Department of Biomedical Engineering50, UNIST-gilUlsan 44919Republic of Koreahkang@unist.ac.krSearch for other works by this author on:Kyungha Kim;Kyungha KimUlsan National Institute of Science and Technology, Department of Biomedical Engineering50, UNIST-gilUlsan 44919Republic of Koreahkang@unist.ac.krSearch for other works by this author on:Suhyun Park;Suhyun ParkUlsan National Institute of Science and Technology, Department of Biomedical Engineering50, UNIST-gilUlsan 44919Republic of Koreahkang@unist.ac.krSearch for other works by this author on:Noehyun Myung;Noehyun MyungUlsan National Institute of Science and Technology, Department of Biomedical Engineering50, UNIST-gilUlsan 44919Republic of Koreahkang@unist.ac.krSearch for other works by this author on:Hyun-wook KangHyun-wook KangUlsan National Institute of Science and Technology, Department of Biomedical Engineering50, UNIST-gilUlsan 44919Republic of Koreahkang@unist.ac.krSearch for other works by this author on:
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Chapter 12: 3D Modeling of Hepatic Tissuep253-278ByMary C. Regier;Mary C. RegierDepartment of Bioengineering, University of Washington850 Republican Street, Brotman Building, Room 442SeattleWA 98109USAksteve@uw.eduInstitute for Stem Cell and Regenerative Medicine, University of Washington850 Republican Street, Brotman Building, Room 442SeattleWA 98109USASearch for other works by this author on:Kelly R. StevensKelly R. StevensDepartment of Bioengineering, University of Washington850 Republican Street, Brotman Building, Room 442SeattleWA 98109USAksteve@uw.eduDepartment of Pathology, University of Washington850 Republican Street, Brotman Building, Room 442SeattleWA 98109USAInstitute for Stem Cell and Regenerative Medicine, University of Washington850 Republican Street, Brotman Building, Room 442SeattleWA 98109USASearch for other works by this author on:
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Chapter 13: Microphysiological Models of the Respiratory Systemp279-293ByDongeun HuhDongeun HuhSearch for other works by this author on:
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Chapter 14: 3D Tissue Model of Cancersp294-311BySeok ChungSeok ChungKU-KIST Graduate School of Converging Science and Technology, Korea UniversitySeoulKoreaSearch for other works by this author on:
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Chapter 15: 3D Tissue Models for Toxicologyp312-328ByGregor Skeldon;Gregor SkeldonSchool of Engineering and Physical Sciences, Heriot-Watt UniversityEdinburghUKSearch for other works by this author on:David C. Hay;David C. HayMRC Centre for Regenerative Medicine, University of EdinburghEdinburghUKSearch for other works by this author on:Wenmiao ShuWenmiao ShuSearch for other works by this author on:
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Chapter 16: Ethics of Using Human Cells/Tissues for 3D Tissue Modelsp329-344ByJung Yeon Lim;Jung Yeon LimThe Catholic University of Korea, Department of Biomedical Science, College of MedicineBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of Koreakswent@catholic.ac.krThe Catholic University of Korea, Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's HospitalBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of KoreaSearch for other works by this author on:Do Hyun Kim;Do Hyun KimThe Catholic University of Korea, Department of Biomedical Science, College of MedicineBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of Koreakswent@catholic.ac.krThe Catholic University of Korea, Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's HospitalBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of KoreaSearch for other works by this author on:Sun Hwa Park;Sun Hwa ParkThe Catholic University of Korea, Department of Biomedical Science, College of MedicineBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of Koreakswent@catholic.ac.krThe Catholic University of Korea, Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's HospitalBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of KoreaSearch for other works by this author on:Sung Won KimSung Won KimThe Catholic University of Korea, Department of Biomedical Science, College of MedicineBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of Koreakswent@catholic.ac.krThe Catholic University of Korea, Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's HospitalBanpo-Daero, Seocho-gu, Seoul, 137-701Republic of KoreaSearch for other works by this author on:
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