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J W L HOOTON, H F PABST, D W SPADY, V PAETKAU, Human colostrum contains an activity that inhibits the production of IL-2, Clinical and Experimental Immunology, Volume 86, Issue 3, December 1991, Pages 520–524, https://doi.org/10.1111/j.1365-2249.1991.tb02963.x
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SUMMARY
The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor β.