Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation Sanna, Maria D.; Stark, Holger; Lucarini, Laura; More Sanna, Maria D.; Stark, Holger; Lucarini, Laura; Ghelardini, Carla; Masini, Emanuela; Galeotti, Nicoletta Less PAIN. 156(12):2492-2504, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Histamine H4 receptor modulation might have a broader role in pain states than those secondary to inflammation. Histamine H4 receptor agonists could be a promising treatment of neuropathic pain. Buy SDC
Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia Miletic, Gordana; Hermes, Jessie L.; Bosscher, Georgia L.; More Miletic, Gordana; Hermes, Jessie L.; Bosscher, Georgia L.; Meier, Brenton M.; Miletic, Vjekoslav Less PAIN. 156(12):2514-2520, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Protein kinase C gamma-mediated persistent phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid receptors in the postsynaptic density of spinal dorsal horn neurons may elicit neuropathic pain because of the loss of calcineurin dephosphorylating activity. Buy
Inhibition of the primary sensorimotor cortex by topical anesthesia of the forearm in patients with complex regional pain syndrome Strauss, Sebastian; Grothe, Matthias; Usichenko, Taras; More Strauss, Sebastian; Grothe, Matthias; Usichenko, Taras; Neumann, Nicola; Byblow, Winston D.; Lotze, Martin Less PAIN. 156(12):2556-2561, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Cutaneous anesthesia of the forearm in patients with complex regional pain syndrome was used to increase intracortical inhibition and decrease impaired spatial tactile resolution of the affected limb. Buy SDC
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats Dalm, Brian D.; Reddy, Chandan G.; Howard, Matthew A.; More Dalm, Brian D.; Reddy, Chandan G.; Howard, Matthew A.; Kang, Sinyoung; Brennan, Timothy J. Less PAIN. 156(12):2562-2571, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Spontaneous nociception, tested by conditioned place preference, and spontaneous dorsal horn neuron activity were not evident in the rat model of chronic constriction injury to the sciatic nerve. Buy
Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats Liu, Su; Liu, Yue-Peng; Huang, Zhi-Jiang; More Liu, Su; Liu, Yue-Peng; Huang, Zhi-Jiang; Zhang, Yan-Kai; Song, Angela A.; Ma, Ping-Chuan; Song, Xue-Jun Less PAIN. 156(12):2572-2584, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Ryk receptor-mediated Wnt signaling pathway is critical to sensitization of the peripheral sensory neurons and spinal dorsal horn neurons after nerve injury. Buy
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness Cohen, Steven P.; Peterlin, B. Lee; Fulton, Larry; More Cohen, Steven P.; Peterlin, B. Lee; Fulton, Larry; Neely, Edward T.; Kurihara, Connie; Gupta, Anita; Mali, Jimmy; Fu, Diana C.; Jacobs, Michael B.; Plunkett, Anthony R.; Verdun, Aubrey J.; Stojanovic, Milan P.; Hanling, Steven; Constantinescu, Octav; White, Ronald L.; McLean, Brian C.; Pasquina, Paul F.; Zhao, Zirong Less PAIN. 156(12):2585-2594, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: In this double-blind, multicenter, comparative-effectiveness study, we found that pulsed radiofrequency provided better pain relief than steroid injections in patients with occipital neuralgia. Buy
Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice Bobinski, Franciane; Ferreira, Tamara A.A.; Córdova, Marina M.; More Bobinski, Franciane; Ferreira, Tamara A.A.; Córdova, Marina M.; Dombrowski, Patrícia A.; da Cunha, Cláudio; Santo, Caroline C. do Espírito; Poli, Anicleto; Pires, Rita G.W.; Martins-Silva, Cristina; Sluka, Kathleen A.; Santos, Adair R.S. Less PAIN. 156(12):2595-2606, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: This study shows that analgesia produced by 2 weeks of low-intensity exercise after peripheral nerve injury in mice is dependent on serotonergic neurotransmission on brainstem. Buy
Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer Stinson, Jennifer N.; Jibb, Lindsay A.; Nguyen, Cynthia; More Stinson, Jennifer N.; Jibb, Lindsay A.; Nguyen, Cynthia; Nathan, Paul C.; Maloney, Anne Marie; Dupuis, L. Lee; Gerstle, J. Ted; Hopyan, Sevan; Alman, Benjamin A.; Strahlendorf, Caron; Portwine, Carol; Johnston, Donna L. Less PAIN. 156(12):2607-2615, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: The construct validity and internal consistency reliability of a real-time data capture app to assess pain in children and adolescents with cancer has been demonstrated. Go to Full Text of this Article Open SDC
Increasing placebo responses over time in U.S. clinical trials of neuropathic pain Tuttle, Alexander H.; Tohyama, Sarasa; Ramsay, Tim; More Tuttle, Alexander H.; Tohyama, Sarasa; Ramsay, Tim; Kimmelman, Jonathan; Schweinhardt, Petra; Bennett, Gary J.; Mogil, Jeffrey S. Less PAIN. 156(12):2616-2626, December 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Placebo responses in clinical trials of neuropathic pain have increased considerably over 1990 to 2013. This trend has been driven by studies conducted in the United States. Buy SDC
Clinical, histological, and biochemical predictors of postsurgical neuropathic pain Martinez, Valéria; Üçeyler, Nurcan; Ben Ammar, Skander; More Martinez, Valéria; Üçeyler, Nurcan; Ben Ammar, Skander; Alvarez, Jean-Claude; Gaudot, Fabrice; Sommer, Claudia; Bouhassira, Didier; Fletcher, Dominique Less PAIN. 156(11):2390-2398, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Neuropathic pain severity is inversely correlated with small nerve fiber loss, but not with TNF-α and NGF gene expression, after iliac crest bone harvest. Buy
Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations van Hecke, Oliver; Kamerman, Peter R.; Attal, Nadine; More van Hecke, Oliver; Kamerman, Peter R.; Attal, Nadine; Baron, Ralf; Bjornsdottir, Gyda; Bennett, David L.H.; Bennett, Michael I.; Bouhassira, Didier; Diatchenko, Luda; Freeman, Roy; Freynhagen, Rainer; Haanpää, Maija; Jensen, Troels S.; Raja, Srinivasa N.; Rice, Andrew S.C.; Seltzer, Ze'ev; Thorgeirsson, Thorgeir E.; Yarnitsky, David; Smith, Blair H. Less PAIN. 156(11):2337-2353, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: NeuPSIG proposes a consensus-based standardised approach to phenotyping neuropathic pain for genetic studies in humans and guidelines for reporting the phenotyping of cases and controls. Go to Full Text of this Article Open SDC
Nerve growth factor–induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain Cheng, Chau-Fu; Cheng, Jen-Kun; Chen, Chih-Yang; More Cheng, Chau-Fu; Cheng, Jen-Kun; Chen, Chih-Yang; Rau, Ruey-Horng; Chang, Yu-Cheng; Tsaur, Meei-Ling Less PAIN. 156(11):2295-2309, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Elevated nerve growth factor after peripheral nerve injury induces neurite sprouting and the formation of synapse-like structures within the contralateral dorsal root ganglion, leading to the development of chronic mirror-image pain. Buy SDC
Pain relief with lidocaine 5% patch in localized peripheral neuropathic pain in relation to pain phenotype: a randomised, double-blind, and placebo-controlled, phenotype panel study Demant, Dyveke T.; Lund, Karen; Finnerup, Nanna B.; More Demant, Dyveke T.; Lund, Karen; Finnerup, Nanna B.; Vollert, Jan; Maier, Christoph; Segerdahl, Märtha S.; Jensen, Troels S.; Sindrup, Søren H. Less PAIN. 156(11):2234-2244, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Lidocaine 5% patch is shown to have significant effect on peripheral neuropathic pain and some data point at better effect in the “irritable nociceptor” phenotype. Buy
Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ Krukowski, Karen; Nijboer, Cora H.; Huo, XiaoJiao; More Krukowski, Karen; Nijboer, Cora H.; Huo, XiaoJiao; Kavelaars, Annemieke; Heijnen, Cobi J. Less PAIN. 156(11):2184-2192, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Chemotherapy-induced peripheral neuropathy is a problem for individuals with cancer. This study demonstrates that pifithrin-μ is a highly promising candidate for prevention of chemotherapy-induced peripheral neuropathy. Buy
Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial Serra, Jordi; Duan, W. Rachel; Locke, Charles; More Serra, Jordi; Duan, W. Rachel; Locke, Charles; Solà, Romà; Liu, Wei; Nothaft, Wolfram Less PAIN. 156(11):2175-2183, November 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: A randomized study evaluated the effects of ABT-639, compared with placebo, on abnormal spontaneous activity in peripheral C-nociceptors using microneurography in patients with diabetic neuropathy. Buy
Mechanism-based therapy for neuropathic pain—a concept in danger? Binder, Andreas; Baron, Ralf Binder, Andreas; Baron, Ralf Less PAIN. 156(11):2113-2114, November 2015. Favorite PDF Permissions Buy
Neuropathic pain as part of chronic widespread pain: environmental and genetic influences Momi, Sukhleen K.; Fabiane, Stella Maris; Lachance, Genevieve; More Momi, Sukhleen K.; Fabiane, Stella Maris; Lachance, Genevieve; Livshits, Gregory; Williams, Frances M. K. Less PAIN. 156(10):2100-2106, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: The prevalence of neuropathic pain within chronic widespread pain is 16%. Neuropathic pain is 37% heritable and shares underlying genetic factors with chronic widespread pain. Buy SDC
A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain Ziegler, Dan; Duan, W. Rachel; An, Guohua; More Ziegler, Dan; Duan, W. Rachel; An, Guohua; Thomas, James W.; Nothaft, Wolfram Less PAIN. 156(10):2013-2020, October 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Treatment with ABT-639 100 mg for 6 weeks did not significantly reduce pain in patients with diabetic peripheral neuropathy. Buy SDC
Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury López-Álvarez, Víctor M.; Modol, Laura; Navarro, Xavier; More López-Álvarez, Víctor M.; Modol, Laura; Navarro, Xavier; Cobianchi, Stefano Less PAIN. 156(9):1812-1825, September 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Specific treadmill exercise reduces neuropathic pain by modulating neurotrophin expression that induces collateral sprouting and disruption of NKCC1 and KCC2 homeostasis after sciatic nerve injury. Buy
Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations Bannister, Kirsty; Patel, Ryan; Goncalves, Leonor; More Bannister, Kirsty; Patel, Ryan; Goncalves, Leonor; Townson, Louisa; Dickenson, Anthony H. Less PAIN. 156(9):1803-1811, September 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Diffuse noxious inhibitory controls (DNICs) are reduced after neuropathy. α2 adrenoceptor- and 5-HT3 receptor-mediated mechanisms underlie DNIC because drugs that modulate these receptors restore DNIC-mediated inhibition after neuropathy. Buy
