Review
doi: 10.1006/scdb.1999.0311.
Plasticity of cell fate: insights from heterokaryons
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- PMID: 10441538
- DOI: 10.1006/scdb.1999.0311
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Review
Plasticity of cell fate: insights from heterokaryons
Semin Cell Dev Biol.
1999 Jun.
Free article
Abstract
Experiments with somatic cell hybrids and stable heterokaryons have demonstrated that differentiated cells exhibit a remarkable capacity to change. Heterokaryons have been particularly useful in determining the extent to which the differentiated state of a cell is plastic. Cell fate can be altered by a change in the balance of positive and negative trans-acting regulators. Although a single regulator may be sufficient in certain environments to trigger a change in cell fate, that regulator may be ineffective in other cell contexts where it encounters a different composition of regulators.
Copyright 1999 Academic Press.
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