Molecular epidemiology, pathogenesis and prevention of gastric cancer
- PMID: 10590210
- DOI: 10.1093/carcin/20.12.2195
Molecular epidemiology, pathogenesis and prevention of gastric cancer
Abstract
Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the world, the reasons for this decline are not well understood and its etiology remains unclear. Several factors are suspected to play a role in gastric carcinogenesis, including the effects of diet, exogenous chemicals, intragastric synthesis of carcinogens, genetic factors, infectious agents and pathological conditions in the stomach (such as gastritis). A new look at the results of epidemiological and experimental studies is important for the establishment of strategies for control. Since cancer of the stomach has a very poor prognosis in its more advanced stages, such a control program must have its main focus on primary prevention. This review describes our knowledge about cancer of the stomach regarding epidemiology, pathogenesis and prevention.
Similar articles
-
Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention.Cancer Epidemiol Biomarkers Prev. 2014 May;23(5):700-13. doi: 10.1158/1055-9965.EPI-13-1057. Epub 2014 Mar 11. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 24618998 Free PMC article. Review.
-
Epidemiology of stomach cancer.Methods Mol Biol. 2009;472:467-77. doi: 10.1007/978-1-60327-492-0_23. Methods Mol Biol. 2009. PMID: 19107449 Review.
-
Epidemiology of premalignant gastric lesions: implications for the development of screening and surveillance strategies.Helicobacter. 2007 Nov;12 Suppl 2:22-31. doi: 10.1111/j.1523-5378.2007.00562.x. Helicobacter. 2007. PMID: 17991173 Review.
-
Molecular basis of gastric cancer development and progression.Gastric Cancer. 2004;7(2):61-77. doi: 10.1007/s10120-004-0277-4. Gastric Cancer. 2004. PMID: 15224192 Review.
-
Dietary habits and epidemiology of gastric carcinoma.Hepatogastroenterology. 2001 Nov-Dec;48(42):1537-43. Hepatogastroenterology. 2001. PMID: 11813567
Cited by
-
Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis.BMC Gastroenterol. 2022 Aug 2;22(1):370. doi: 10.1186/s12876-022-02390-y. BMC Gastroenterol. 2022. PMID: 35918654 Free PMC article.
-
Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium.Cancers (Basel). 2021 Jul 30;13(15):3844. doi: 10.3390/cancers13153844. Cancers (Basel). 2021. PMID: 34359744 Free PMC article.
-
Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis.Turk J Gastroenterol. 2020 Dec;31(12):853-859. doi: 10.5152/tjg.2020.19699. Turk J Gastroenterol. 2020. PMID: 33625997 Free PMC article.
-
Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Pooling Project (StoP).Cancers (Basel). 2020 Oct 20;12(10):3064. doi: 10.3390/cancers12103064. Cancers (Basel). 2020. PMID: 33092262 Free PMC article.
-
Interactions between Helicobacter pylori and gastroesophageal reflux disease.Esophagus. 2019 Jan;16(1):52-62. doi: 10.1007/s10388-018-0637-5. Epub 2018 Aug 27. Esophagus. 2019. PMID: 30151653 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
