Radical scavenging activity of tea catechins and their related compounds
- PMID: 10610125
- DOI: 10.1271/bbb.63.1621
Radical scavenging activity of tea catechins and their related compounds
Abstract
(-)-Epigallocatechin gallate was found to be the most effective scavenger among tea catechins for the superoxide anion, hydroxyl radical, and 1,1-diphenyl-3-picrylhydrazyl radical. Examination of the scavenging effects of tea catechins and their glucosides on superoxide anion showed that the presence of at least an ortho-dihydroxyl group in the B ring and a galloyl moiety at the 3 position was important in maintaining the effectiveness of the radical scavenging ability. Stoichiometric factors of tea catechins were estimated to be 2 for (+)-catechin and (-)-epicatechin, 5 for (-)-epigallocatechin, 7 for (-)-epicatechin gallate, and 10 for (-)-epigallocatechin gallate.
Similar articles
-
Beneficial Properties of Green Tea Catechins.Int J Mol Sci. 2020 Mar 4;21(5):1744. doi: 10.3390/ijms21051744. Int J Mol Sci. 2020. PMID: 32143309 Free PMC article. Review.
-
Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway.Neurosignals. 2005;14(1-2):46-60. doi: 10.1159/000085385. Neurosignals. 2005. PMID: 15956814 Review.
-
Chemical studies on antioxidant mechanism of tea catechins: analysis of radical reaction products of catechin and epicatechin with 2,2-diphenyl-1-picrylhydrazyl.Bioorg Med Chem. 2002 Jul;10(7):2233-7. doi: 10.1016/s0968-0896(02)00089-5. Bioorg Med Chem. 2002. PMID: 11983520
-
ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers.Biochim Biophys Acta. 1999 Mar 14;1427(1):13-23. doi: 10.1016/s0304-4165(98)00168-8. Biochim Biophys Acta. 1999. PMID: 10082983
-
Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical.Free Radic Biol Med. 1996;21(6):895-902. doi: 10.1016/0891-5849(96)00237-7. Free Radic Biol Med. 1996. PMID: 8902534
Cited by
-
EGCG Attenuates CA1 Neuronal Death by Regulating GPx1, NF-κB S536 Phosphorylation and Mitochondrial Dynamics in the Rat Hippocampus following Status Epilepticus.Antioxidants (Basel). 2023 Apr 20;12(4):966. doi: 10.3390/antiox12040966. Antioxidants (Basel). 2023. PMID: 37107343 Free PMC article.
-
Catechins: Protective mechanism of antioxidant stress in atherosclerosis.Front Pharmacol. 2023 Mar 24;14:1144878. doi: 10.3389/fphar.2023.1144878. eCollection 2023. Front Pharmacol. 2023. PMID: 37033663 Free PMC article. Review.
-
Effect of epigallocatechin gallate in green tea on preventing lens opacity and αB-crystallin aggregation in rat model of diabetes.Int J Ophthalmol. 2023 Mar 18;16(3):342-347. doi: 10.18240/ijo.2023.03.02. eCollection 2023. Int J Ophthalmol. 2023. PMID: 36935798 Free PMC article.
-
Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches.Antioxidants (Basel). 2023 Feb 3;12(2):373. doi: 10.3390/antiox12020373. Antioxidants (Basel). 2023. PMID: 36829932 Free PMC article. Review.
-
Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis.Int J Mol Sci. 2022 Dec 25;24(1):340. doi: 10.3390/ijms24010340. Int J Mol Sci. 2022. PMID: 36613784 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources