Differential involvement of dopamine in mediating the discriminative stimulus effects of low and high doses of caffeine in rats
- PMID: 10780285
- DOI: 10.1097/00008877-199912000-00001
Differential involvement of dopamine in mediating the discriminative stimulus effects of low and high doses of caffeine in rats
Abstract
The hypothesis that low and high doses of caffeine produce effects that are differentially mediated by dopamine (DA) receptor mechanisms was investigated in rats trained to discriminate either 10 or 56 mg/kg of caffeine from saline. Rats trained to discriminate 56 mg/kg of caffeine acquired the discrimination in an average of 74 sessions, whereas rats trained to discriminate 10 mg/kg of caffeine required an average of 108 sessions. The DA D1 receptor agonist SKF 81297 and the DA D2 receptor agonist R(-)-propylnorapomorphine (NPA) generalized partially (50-75%) in rats trained to discriminate 10 mg/kg of caffeine, but produced predominantly saline-appropriate responding (< 40%) in rats trained to discriminate 56 mg/kg of caffeine. When SKF 81297 and NPA were combined, stimulus generalization was no greater than it was when either agonist was tested alone. The DA uptake inhibitors cocaine and GBR 12909 produced predominantly saline-appropriate responding in both groups of rats. Neither the DA D1 receptors antagonists SCH 23390 and SCH 31966, nor the DA D2 receptor antagonists eticlopride and sulpiride, generalized in rats trained to discriminate 10 or 56 mg/kg of caffeine. When administered in combination with caffeine, both the DA D1 and DA D2 antagonists antagonized completely the discriminative stimulus effects of the low training dose of caffeine, but did not alter the discriminative stimulus effects of the high training dose. These results suggest that the discriminative stimulus effects of 10 mg/kg of caffeine, but not 56 mg/kg of caffeine, are dependent on, but not limited to, DA D1 and D2 receptor mechanisms.
Similar articles
-
Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.Psychopharmacology (Berl). 2016 May;233(10):1963-79. doi: 10.1007/s00213-016-4212-2. Epub 2016 Jan 20. Psychopharmacology (Berl). 2016. PMID: 26786412 Free PMC article. Review.
-
Dopaminergic involvement in the discriminative-stimulus effects of methamphetamine in rats.Psychopharmacology (Berl). 2000 Feb;148(2):209-16. doi: 10.1007/s002130050044. Psychopharmacology (Berl). 2000. PMID: 10663437
-
Analysis of D2 and D3 receptor-selective ligands in rats trained to discriminate cocaine from saline.Pharmacol Biochem Behav. 1999 Oct;64(2):373-8. doi: 10.1016/s0091-3057(99)00064-7. Pharmacol Biochem Behav. 1999. PMID: 10515316
-
Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems.Pharmacol Biochem Behav. 1997 Jul;57(3):601-7. doi: 10.1016/s0091-3057(96)00434-0. Pharmacol Biochem Behav. 1997. PMID: 9218282 Review.
-
Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus.Pharmacol Biochem Behav. 1994 Jul;48(3):817-20. doi: 10.1016/0091-3057(94)90353-0. Pharmacol Biochem Behav. 1994. PMID: 7938142
Cited by
-
Discriminative Stimulus Effects of Binary Drug Mixtures: Studies with Cocaine, MDPV, and Caffeine.J Pharmacol Exp Ther. 2016 Oct;359(1):1-10. doi: 10.1124/jpet.116.234252. Epub 2016 Aug 4. J Pharmacol Exp Ther. 2016. PMID: 27493274 Free PMC article.
-
Comparison of Caffeine and d-amphetamine in Cocaine-Dependent Subjects: Differential Outcomes on Subjective and Cardiovascular Effects, Reward Learning, and Salivary Paraxanthine.J Addict Res Ther. 2014;5(2):176. doi: 10.4172/2155-6105.1000176. J Addict Res Ther. 2014. PMID: 25414797 Free PMC article.
-
Caffeine's Attenuation of Cocaine-Induced Dopamine Release by Inhibition of Adenosine.J Caffeine Res. 2014 Jun 1;4(2):35-40. doi: 10.1089/jcr.2014.0004. J Caffeine Res. 2014. PMID: 25054079 Free PMC article.
-
Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.PLoS One. 2012;7(6):e39709. doi: 10.1371/journal.pone.0039709. Epub 2012 Jun 22. PLoS One. 2012. PMID: 22745815 Free PMC article.
-
ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex.Neuropsychopharmacology. 2012 Feb;37(3):759-69. doi: 10.1038/npp.2011.253. Epub 2011 Oct 19. Neuropsychopharmacology. 2012. PMID: 22012471 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous