Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia
- PMID: 11237807
- DOI: 10.1086/319258
Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia
Abstract
Outbreaks of Mycoplasma pneumoniae (MP) in closed communities can have a high attack rate and can last several months. Azithromycin chemoprophylaxis has not been evaluated as a means of limiting transmission. This randomized, double-blinded placebo-controlled trial of azithromycin was conducted among asymptomatic hospital employees during an MP outbreak. Oropharyngeal swabs were obtained for detection of MP by polymerase chain reaction, and questionnaires were administered to assess clinical illness. Of the 147 employees who were enrolled, 73 received azithromycin and 74 received placebo. Carriage was similar within and between groups at weeks 1 and 6 (9.6% vs. 6.7% and 10.3% vs. 13.2%, respectively). Four episodes of clinically significant respiratory illness occurred in the azithromycin group versus 16 episodes in the placebo group (protective efficacy, 75%; 95% confidence interval, 28%-91%). Use of azithromycin prophylaxis in asymptomatic persons during an MP outbreak in a closed setting may be of value in reducing clinical illness.
Comment in
-
Azithromycin chemoprophylaxis.J Infect Dis. 2001 Sep 1;184(5):657. doi: 10.1086/322797. J Infect Dis. 2001. PMID: 11494171 No abstract available.
Similar articles
-
Mycoplasma Pneumonia in Children and Adolescents.Pediatr Rev. 2020 Jan;41(1):12-19. doi: 10.1542/pir.2018-0016. Pediatr Rev. 2020. PMID: 31894069 Review. No abstract available.
-
Randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population.Clin Infect Dis. 2001 Oct 1;33(7):983-9. doi: 10.1086/322626. Epub 2001 Sep 5. Clin Infect Dis. 2001. PMID: 11528569 Clinical Trial.
-
[Control of a school outbreak of serogroup B meningococcal disease by chemoprophylaxis with azithromycin and ciprofloxacin].An Esp Pediatr. 2000 Nov;53(5):412-7. An Esp Pediatr. 2000. PMID: 11521657 Spanish.
-
Enhanced control of an outbreak of Mycoplasma pneumoniae pneumonia with azithromycin prophylaxis.J Infect Dis. 1998 Jan;177(1):161-6. doi: 10.1086/513818. J Infect Dis. 1998. PMID: 9419183
-
[Mycoplasma pneumoniae respiratory infections in hospitalized patients].Rev Mal Respir. 1994;11(5):473-7. Rev Mal Respir. 1994. PMID: 7816990 Review. French.
Cited by
-
Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection.Front Cell Infect Microbiol. 2023 Apr 11;13:1052020. doi: 10.3389/fcimb.2023.1052020. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37113130 Free PMC article. Review.
-
Use of Azithromycin in Pregnancy: More Doubts than Certainties.Clin Drug Investig. 2022 Nov;42(11):921-935. doi: 10.1007/s40261-022-01203-0. Epub 2022 Sep 24. Clin Drug Investig. 2022. PMID: 36152269 Free PMC article. Review.
-
Case Report and Literature Review: Clinical Characteristics of 10 Children With Mycoplasma pneumoniae-Induced Rash and Mucositis.Front Pediatr. 2022 Mar 3;10:823376. doi: 10.3389/fped.2022.823376. eCollection 2022. Front Pediatr. 2022. PMID: 35311047 Free PMC article.
-
Shuanghuanglian oral preparations combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: A systematic review and meta-analysis of randomized controlled trials.PLoS One. 2021 Jul 13;16(7):e0254405. doi: 10.1371/journal.pone.0254405. eCollection 2021. PLoS One. 2021. PMID: 34255785 Free PMC article.
-
Adverse events in people taking macrolide antibiotics versus placebo for any indication.Cochrane Database Syst Rev. 2019 Jan 18;1(1):CD011825. doi: 10.1002/14651858.CD011825.pub2. Cochrane Database Syst Rev. 2019. PMID: 30656650 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical