Synthesis and function of 3-phosphorylated inositol lipids
- PMID: 11395417
- DOI: 10.1146/annurev.biochem.70.1.535
Synthesis and function of 3-phosphorylated inositol lipids
Abstract
The 3-phosphorylated inositol lipids fulfill roles as second messengers by interacting with the lipid binding domains of a variety of cellular proteins. Such interactions can affect the subcellular localization and aggregation of target proteins, and through allosteric effects, their activity. Generation of 3-phosphoinositides has been documented to influence diverse cellular pathways and hence alter a spectrum of fundamental cellular activities. This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles. Much knowledge has recently been gained through structural insights into the lipid kinases, their interaction with inhibitors, and the way their 3-phosphoinositide products interact with protein targets. This field is now moving toward a genetic dissection of 3-phosphoinositide action in a variety of model organisms. Such approaches will reveal the true role of the 3-phosphoinositides at the organismal level in health and disease.
Similar articles
-
p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring.J Biol Chem. 1999 Jul 30;274(31):22019-24. doi: 10.1074/jbc.274.31.22019. J Biol Chem. 1999. PMID: 10419527
-
Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases.Trends Biochem Sci. 2002 Aug;27(8):426-32. doi: 10.1016/s0968-0004(02)02136-9. Trends Biochem Sci. 2002. PMID: 12151228 Review.
-
PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench.Curr Opin Cell Biol. 2001 Apr;13(2):172-81. doi: 10.1016/s0955-0674(00)00195-2. Curr Opin Cell Biol. 2001. PMID: 11248551 Review.
-
Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.Cell Signal. 2007 Dec;19(12):2444-57. doi: 10.1016/j.cellsig.2007.07.020. Epub 2007 Aug 3. Cell Signal. 2007. PMID: 17826953
-
Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling.Semin Immunol. 2002 Feb;14(1):1-6. doi: 10.1006/smim.2001.0336. Semin Immunol. 2002. PMID: 11884225 Review. No abstract available.
Cited by
-
Understanding Developmental Cell Death Using Drosophila as a Model System.Cells. 2024 Feb 16;13(4):347. doi: 10.3390/cells13040347. Cells. 2024. PMID: 38391960 Free PMC article. Review.
-
Application of Quercetin and its Novel Formulations in the Treatment of Malignancies of Central Nervous System: An Updated Review of Current Evidence based on Molecular Mechanisms.Curr Med Chem. 2024;31(26):4180-4198. doi: 10.2174/0109298673266672231121173432. Curr Med Chem. 2024. PMID: 38265392 Review.
-
Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas.World J Gastroenterol. 2023 Dec 28;29(48):6179-6197. doi: 10.3748/wjg.v29.i48.6179. World J Gastroenterol. 2023. PMID: 38186866 Free PMC article. Review.
-
Serotonin Strengthens a Developing Glutamatergic Synapse through a PI3K-Dependent Mechanism.J Neurosci. 2024 Feb 7;44(6):e1260232023. doi: 10.1523/JNEUROSCI.1260-23.2023. J Neurosci. 2024. PMID: 38169457 Free PMC article.
-
Phosphoinositide Signaling in Immune Cell Migration.Biomolecules. 2023 Nov 24;13(12):1705. doi: 10.3390/biom13121705. Biomolecules. 2023. PMID: 38136577 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials