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. 2001 Aug 8;12(11):2595-9.
doi: 10.1097/00001756-200108080-00060.

Addiction changes orbitofrontal gyrus function: involvement in response inhibition

R Z Goldstein  1 , N D Volkow, G J Wang, J S Fowler, S Rajaram
Affiliations

Addiction changes orbitofrontal gyrus function: involvement in response inhibition

R Z Goldstein et al. Neuroreport. .

Abstract

We used the Stroop task as a measure of the ability to inhibit a prepotent response tendency and examined its association with relative glucose metabolism in selected prefrontal brain regions in cocaine addicts, alcoholics, and controls (17 per group). Results revealed that for the substance abusers, higher orbitofrontal gyrus (OFG) activation was associated with lower conflict (higher score; r = 0.32, p < 0.05). For the controls, higher OFG activation was associated with higher conflict (lower score; r = -0.42, p < 0.05). Thus, at baseline, increased relative activation of the OFG is associated with worse performance in controls and better performance in substance abusers on the Stroop task, suggesting reversal of the role of the OFG as a function of addiction.

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Figures

Fig. 1
Fig. 1
Association between Stroop interference and relative orbital gyrus metabolism in right-handed male 17 control subjects, 17 alcoholics, and 17 cocaine addicts matched for age, education, and estimates of IQ.
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