Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Sep 25;98(20):10983-5.
doi: 10.1073/pnas.211430998.

AKT plays a central role in tumorigenesis

J R Testa  1 , A Bellacosa
Affiliations
Review

AKT plays a central role in tumorigenesis

J R Testa et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Phosphorylation by AKT regulates compartmentalization of multiple substrates involved in cell cycle progression and inhibition of apoptosis. (A) In serum-starved cells, the pro-apoptotic transcription factors of the forkhead family and cell cycle inhibitors p21 and p27 localize in the nucleus, whereas the oncoprotein Mdm2 is restrained in the cytoplasm. (B) After growth factor (GF) stimulation and phosphorylation by AKT, the subcellular localization of these AKT substrates is diametrically changed, contributing to cell cycle progression and inhibition of apoptosis. Cytoplasmic p21 can bind to the apoptosis signal-regulating kinase (ASK1), inhibiting apoptosis. In the absence of p19/p14ARF induction, the Mdm2-p53 complex shuttles into the cytoplasm where p53 is ubiquitinated (Ub) and targeted for degradation.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mayo L D, Donner D B. Proc Natl Acad Sci USA. 2001;98:11598–11603. . (First Published August 14, 2001; 10.1073/pnas.181181198) - PMC - PubMed
    1. Staal S P, Hartley J W, Rowe W P. Proc Natl Acad Sci USA. 1977;74:3065–3067. - PMC - PubMed
    1. Staal S P. Proc Natl Acad Sci USA. 1987;84:5034–5037. - PMC - PubMed
    1. Bellacosa A, Testa J R, Staal S P, Tsichlis P N. Science. 1991;254:274–277. - PubMed
    1. Ahmed N N, Franke T F, Bellacosa A, Datta K, Gonzalez-Portal M E, Taguchi T, Testa J R, Tsichlis P N. Oncogene. 1993;8:1957–1963. - PubMed

Substances

LinkOut - more resources

-