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. 2002 Feb;167(2 Pt 1):753-6.
doi: 10.1016/S0022-5347(01)69139-0.

Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome

Lauri J Miller  1 , Kateri A Fischer, Sandra J Goralnick, Mark Litt, Joseph A Burleson, Peter Albertsen, Donald L Kreutzer
Affiliations

Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome

Lauri J Miller et al. J Urol. 2002 Feb.

Abstract

Purpose: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-gamma and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment.

Materials and methods: We measured levels of IL-8, interferon-gamma, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score.

Results: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-gamma, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p <0.01) and pain severity (r = 0.53, p <0 0.01), and inversely with spousal support (r = -0.39, p <0.04).

Conclusions: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome.

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