Experience-dependent changes in cerebellar contributions to motor sequence learning
- PMID: 11805340
- PMCID: PMC117423
- DOI: 10.1073/pnas.022615199
Experience-dependent changes in cerebellar contributions to motor sequence learning
Abstract
Studies in experimental animals and humans have stressed the role of the cerebellum in motor skill learning. Yet, the relative importance of the cerebellar cortex and deep nuclei, as well as the nature of the dynamic functional changes occurring between these and other motor-related structures during learning, remains in dispute. Using functional magnetic resonance imaging and a motor sequence learning paradigm in humans, we found evidence of an experience-dependent shift of activation from the cerebellar cortex to the dentate nucleus during early learning, and from a cerebellar-cortical to a striatal-cortical network with extended practice. The results indicate that intrinsic modulation within the cerebellum, in concert with activation of motor-related cortical regions, serves to set up a procedurally acquired sequence of movements that is then maintained elsewhere in the brain.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/117423/bin/pq0226151001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/117423/bin/pq0226151002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/117423/bin/pq0226151003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/117423/bin/pq0226151004.gif)
Similar articles
-
Upregulation of cortico-cerebellar functional connectivity after motor learning.Neuroimage. 2016 Mar;128:252-263. doi: 10.1016/j.neuroimage.2015.12.052. Epub 2016 Jan 6. Neuroimage. 2016. PMID: 26767943
-
The multifaceted nature of the relationship between performance and brain activity in motor sequence learning.Neuroimage. 2010 Jan 1;49(1):694-702. doi: 10.1016/j.neuroimage.2009.08.055. Epub 2009 Sep 2. Neuroimage. 2010. PMID: 19732838
-
Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning.Neuropsychologia. 2003;41(3):252-62. doi: 10.1016/s0028-3932(02)00158-6. Neuropsychologia. 2003. PMID: 12457751 Review.
-
Cerebellum activation associated with performance change but not motor learning.Science. 2002 Jun 14;296(5575):2043-6. doi: 10.1126/science.1068524. Science. 2002. PMID: 12065841
-
The cerebellum: a neuronal learning machine?Science. 1996 May 24;272(5265):1126-31. doi: 10.1126/science.272.5265.1126. Science. 1996. PMID: 8638157 Review.
Cited by
-
Progressive increase of brain gray matter volume in individuals with regular soccer training.Sci Rep. 2024 Mar 25;14(1):7023. doi: 10.1038/s41598-024-57501-4. Sci Rep. 2024. PMID: 38528027 Free PMC article.
-
Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.Biomedicines. 2024 Jan 10;12(1):147. doi: 10.3390/biomedicines12010147. Biomedicines. 2024. PMID: 38255252 Free PMC article.
-
Neck Muscle Vibration Alters Cerebellar Processing Associated with Motor Skill Acquisition of a Proprioceptive-Based Task.Brain Sci. 2023 Oct 4;13(10):1412. doi: 10.3390/brainsci13101412. Brain Sci. 2023. PMID: 37891781 Free PMC article.
-
Plasticity-stability dynamics during post-training processing of learning.Trends Cogn Sci. 2024 Jan;28(1):72-83. doi: 10.1016/j.tics.2023.09.002. Epub 2023 Oct 17. Trends Cogn Sci. 2024. PMID: 37858389 Review.
-
Role of cerebellum in sleep-dependent memory processes.Front Syst Neurosci. 2023 Apr 18;17:1154489. doi: 10.3389/fnsys.2023.1154489. eCollection 2023. Front Syst Neurosci. 2023. PMID: 37143709 Free PMC article. Review.
References
-
- Bloedel J R. Behav Brain Sci. 1992;15:666–678.
-
- Bloedel J R, Bracha V, Milak M, Shimansky Y. Prog Brain Res. 1997;114:499–509. - PubMed
-
- King D A, Krupa D J, Foy M R, Thompson R F. Int Rev Neurobiol. 2001;45:313–337. - PubMed
-
- Doyon J. In: The Cerebellum and Cognition. Schmahmann J D, editor. San Diego: Academic; 1997. pp. 273–294.
-
- Thach W T. Trends Cogn Sci. 1998;2:331–337. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources