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. 2001 Dec;3(6):1131-7.
doi: 10.1089/152308601317203639.

Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes

J Vider  1 , D E Laaksonen, A Kilk, M Atalay, J Lehtmaa, M Zilmer, C K Sen
Affiliations

Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes

J Vider et al. Antioxid Redox Signal. 2001 Dec.

Abstract

Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.

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