Sibling rivalry in the E2F family
- PMID: 11823794
- DOI: 10.1038/nrm714
Sibling rivalry in the E2F family
Abstract
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
Similar articles
-
Differential regulation of apoptotic genes by Rb in human versus mouse cells.Oncogene. 2004 Apr 8;23(15):2587-99. doi: 10.1038/sj.onc.1207330. Oncogene. 2004. PMID: 15048095
-
Evolving intricacies and implications of E2F1 regulation.FASEB J. 2003 Apr;17(6):569-74. doi: 10.1096/fj.02-0431rev. FASEB J. 2003. PMID: 12665469 Review.
-
Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferation.Cytokine. 2002 Jan 21;17(2):91-7. doi: 10.1006/cyto.2001.0992. Cytokine. 2002. PMID: 11886176
-
Expression of the E2F family of transcription factors during murine development.Int J Dev Biol. 2000 Apr;44(3):267-77. Int J Dev Biol. 2000. PMID: 10853823
-
Toward an understanding of the functional complexity of the E2F and retinoblastoma families.Cell Growth Differ. 1998 Aug;9(8):585-93. Cell Growth Differ. 1998. PMID: 9716176 Review. No abstract available.
Cited by
-
Molecular and Therapeutic Roles of Non-Coding RNAs in Oral Cancer-A Review.Molecules. 2024 May 20;29(10):2402. doi: 10.3390/molecules29102402. Molecules. 2024. PMID: 38792263 Free PMC article. Review.
-
Selective Occupation by E2F and RB of Loci Expressed by RNA Polymerase III.Cancers (Basel). 2024 Jan 23;16(3):481. doi: 10.3390/cancers16030481. Cancers (Basel). 2024. PMID: 38339234 Free PMC article.
-
DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.Anal Cell Pathol (Amst). 2023 Dec 20;2023:1477658. doi: 10.1155/2023/1477658. eCollection 2023. Anal Cell Pathol (Amst). 2023. PMID: 38152068 Free PMC article.
-
Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression.Biology (Basel). 2023 Dec 11;12(12):1511. doi: 10.3390/biology12121511. Biology (Basel). 2023. PMID: 38132337 Free PMC article. Review.
-
E2F5 Targeted by Let-7d-5p Facilitates Cell Proliferation, Metastasis and Immune Escape in Gallbladder Cancer.Dig Dis Sci. 2024 Feb;69(2):463-475. doi: 10.1007/s10620-023-08209-4. Epub 2023 Dec 12. Dig Dis Sci. 2024. PMID: 38087129
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources