Differing mechanisms of cold-induced changes in capillary supply in m. tibialis anterior of rats and hamsters
- PMID: 11914391
- DOI: 10.1242/jeb.205.6.829
Differing mechanisms of cold-induced changes in capillary supply in m. tibialis anterior of rats and hamsters
Abstract
The physiological, metabolic and anatomical adaptations of skeletal muscle to chronic cold exposure were investigated in Wistar rats (Rattus norvegicus), a species that defends core temperature, and Syrian hamsters (Mesocricetus auratus), which may adopt a lower set point under unfavourable conditions. Animals were exposed to a simulated onset of winter in an environmental chamber, progressively shortening photoperiod and reducing temperature from 12 h:12 h L:D and 22 degrees C to 1 h:23 h L:D and 5 degrees C over 4 weeks. The animals were left at 4 degrees C for a further 4 weeks to complete the process of cold-acclimation. M. tibialis anterior from control (euthermic) and cold-acclimated animals of similar mass showed a significant hyperactivity-induced hypertrophy in the rat, but a small disuse atrophy in the hamster. Little evidence was found for interconversion among fibre types in skeletal muscle on cold-acclimation, and only modest differences were seen in activity of oxidative or glycolytic enzymes in either species. However, adjustments in Type II fibre size paralleled the muscle hypertrophy in rat and atrophy in hamster. Cold-induced angiogenesis was present in the rat, averaging a 28 % increase in capillary-to-fibre ratio (C:F) but, as this was balanced by fibre hypertrophy across the whole muscle, there was no change in capillary density (CD). In contrast, the C:F was similar in both groups of hamsters, whereas CD rose by 33 % in line with fibre atrophy. Within distinct regions of the m. tibialis anterior, there was a correlation between angiogenesis and fibre size in rats, in which oxygen diffusion distance increased, but not in hamsters, in which there was a reduced oxygen diffusion distance. Consequently, the change in C:F was greatest (39 %) in the glycolytic cortex region of the m. tibialis anterior in rats. We conclude that non-hibernator and hibernator rodents improve peripheral oxygen transport following cold-acclimation by different mechanisms. In rats, an increase in fibre girth was accompanied by a true angiogenesis, while the improved apparent capillary supply in hamsters was due to smaller fibre diameters. These responses are consistent with the strategies of resisting and accommodating, respectively, an annual fall in environmental temperature.
Similar articles
-
The role of the microcirculation in muscle function and plasticity.J Muscle Res Cell Motil. 2019 Jun;40(2):127-140. doi: 10.1007/s10974-019-09520-2. Epub 2019 Jun 5. J Muscle Res Cell Motil. 2019. PMID: 31165949 Free PMC article. Review.
-
Cold exposure differentially stimulates angiogenesis in glycolytic and oxidative muscles of rats and hamsters.Exp Physiol. 2003 Nov;88(6):741-6. doi: 10.1113/eph8802630. Exp Physiol. 2003. PMID: 14603372
-
Temperature and angiogenesis: the possible role of mechanical factors in capillary growth.Comp Biochem Physiol A Mol Integr Physiol. 2002 Aug;132(4):773-87. doi: 10.1016/s1095-6433(02)00047-8. Comp Biochem Physiol A Mol Integr Physiol. 2002. PMID: 12095862 Review.
-
Differential effects of cold exposure on muscle fibre composition and capillary supply in hibernator and non-hibernator rodents.Exp Physiol. 2001 Sep;86(5):629-39. doi: 10.1113/eph8602260. Exp Physiol. 2001. PMID: 11571492
-
The metabolic characteristics of the locomotory muscles of grey seals (Halichoerus grypus), harbour seals (Phoca vitulina) and Antarctic fur seals (Arctocephalus gazella).J Exp Biol. 1994 Sep;194:33-46. doi: 10.1242/jeb.194.1.33. J Exp Biol. 1994. PMID: 7964404
Cited by
-
Distinct Transcriptional Responses of Skeletal Muscle to Short-Term Cold Exposure in Tibetan Pigs and Bama Pigs.Int J Mol Sci. 2023 Apr 18;24(8):7431. doi: 10.3390/ijms24087431. Int J Mol Sci. 2023. PMID: 37108597 Free PMC article.
-
Skeletal muscle adaptation to indirect electrical stimulation: divergence between microvascular and metabolic adaptations.Exp Physiol. 2023 Jun;108(6):891-911. doi: 10.1113/EP091134. Epub 2023 Apr 7. Exp Physiol. 2023. PMID: 37026596 Free PMC article.
-
Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity.Front Physiol. 2022 Oct 17;13:975652. doi: 10.3389/fphys.2022.975652. eCollection 2022. Front Physiol. 2022. PMID: 36324307 Free PMC article.
-
Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats.Front Physiol. 2021 May 31;12:673095. doi: 10.3389/fphys.2021.673095. eCollection 2021. Front Physiol. 2021. PMID: 34135770 Free PMC article.
-
Long-Term Evaluation of Functional Outcomes Following Rat Volumetric Muscle Loss Injury and Repair.Tissue Eng Part A. 2020 Feb;26(3-4):140-156. doi: 10.1089/ten.TEA.2019.0126. Epub 2020 Jan 23. Tissue Eng Part A. 2020. PMID: 31578935 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources