Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults
- PMID: 12038947
- DOI: 10.1001/archinte.162.11.1286
Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults
Abstract
Background: Physical activity has been associated with a reduced risk of coronary heart disease, but the mechanism underlying this association is unclear. Because coronary heart disease is increasingly seen as an inflammatory process, it might be reasonable to hypothesize that physical activity reduces risk of coronary heart disease by reducing or preventing inflammation.
Methods: The study examined the relationship between physical activity and elevated inflammation as indicated by a high C-reactive protein level, white blood cell count, or fibrinogen level. Study subjects were 3638 apparently healthy US men and women 40 years and older who participated in the Third National Health and Nutrition Examination Survey.
Results: More frequent physical activity was independently associated with a lower odds of having an elevated C-reactive protein level. Compared with those engaging in physical activity 0 to 3 times per month, the odds of having an elevated C-reactive protein level was reduced among those engaging in physical activity 4 to 21 times per month (odds ratio, 0.77; 95% confidence interval, 0.58-1.02) and 22 or more times per month (odds ratio, 0.63; 95% confidence interval, 0.43-0.93) (P for trend,.02). Similar associations were seen for white blood cell count and fibrinogen levels.
Conclusions: More frequent physical activity is independently associated with a lower odds of having elevated inflammation levels among apparently healthy US adults 40 years and older, independent of several confounding factors. The results suggest that the association between physical activity and reduced coronary heart disease risk may be mediated by anti-inflammatory effects of regular physical activity.
Similar articles
-
Association between leisure time physical activity and markers of chronic inflammation related to coronary heart disease.Atherosclerosis. 2004 Oct;176(2):303-10. doi: 10.1016/j.atherosclerosis.2004.05.007. Atherosclerosis. 2004. PMID: 15380453
-
Physical activity and coronary heart disease: prevention and effect on risk factors.Cardiol Rev. 2003 Jan-Feb;11(1):21-5. doi: 10.1097/00045415-200301000-00005. Cardiol Rev. 2003. PMID: 12493132 Review.
-
Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults.Epidemiology. 2002 Sep;13(5):561-8. doi: 10.1097/00001648-200209000-00012. Epidemiology. 2002. PMID: 12192226
-
Association between pulse pressure and C-reactive protein among apparently healthy US adults.Hypertension. 2002 Feb;39(2):197-202. doi: 10.1161/hy0202.104270. Hypertension. 2002. PMID: 11847183
-
The association of c-reactive protein, serum amyloid a and fibrinogen with prevalent coronary heart disease--baseline findings of the PAIS project.Atherosclerosis. 2001 Jun;156(2):451-6. doi: 10.1016/s0021-9150(00)00681-x. Atherosclerosis. 2001. PMID: 11395043
Cited by
-
Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein.Nutrients. 2024 Mar 19;16(6):888. doi: 10.3390/nu16060888. Nutrients. 2024. PMID: 38542799 Free PMC article.
-
Associations Between Leisure-Time Physical Activity Level and Peripheral Immune Cell Populations in the US General Population, Analysis of the National Health and Nutrition Examination Survey Data, 1999-2018.Sports Med Open. 2023 Oct 28;9(1):101. doi: 10.1186/s40798-023-00643-y. Sports Med Open. 2023. PMID: 37897560 Free PMC article.
-
"Does Physical Exercise Promote Health Benefits for Diabetic Patients during the COVID-19 Pandemic?": A Systematic Review.Sports (Basel). 2023 Oct 3;11(10):192. doi: 10.3390/sports11100192. Sports (Basel). 2023. PMID: 37888519 Free PMC article. Review.
-
Association between subjective social status and physical frailty in older adults in India: perceived discrimination and III-treatment as mediators and moderators.Aging Clin Exp Res. 2023 Nov;35(11):2517-2530. doi: 10.1007/s40520-023-02531-7. Epub 2023 Aug 29. Aging Clin Exp Res. 2023. PMID: 37642931
-
Difference of cardiac rehabilitation in the morning or evening on indexes of left ventricular and N-terminal pro-brain natriuretic peptide: a randomized controlled trial.Ann Med Surg (Lond). 2023 Jun 9;85(7):3482-3490. doi: 10.1097/MS9.0000000000000580. eCollection 2023 Jul. Ann Med Surg (Lond). 2023. PMID: 37427217 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials