Apoptosis as a therapeutic tool in rheumatoid arthritis
- PMID: 12094227
- DOI: 10.1038/nri846
Apoptosis as a therapeutic tool in rheumatoid arthritis
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory synovitis that is dominated by the presence of macrophages, lymphocytes and synovial fibroblasts, which leads to the destruction of bone and cartilage. The effectiveness of therapies that are directed against tumour-necrosis factor and interleukin-1 has identified macrophages as a crucial target for therapeutic intervention. However, not all patients respond to these therapies, and the benefits of this form of treatment are short lived. Recent work indicates that the insufficient apoptosis of inflammatory cells in the RA joint might contribute to pathogenesis. In this article, I characterize the mechanisms that prevent the apoptosis of chronic inflammatory cells in the RA joint, to identify potential new targets for the treatment of RA.
Similar articles
-
Cell death in rheumatoid arthritis.Apoptosis. 2009 Apr;14(4):447-54. doi: 10.1007/s10495-009-0317-y. Apoptosis. 2009. PMID: 19199037 Review.
-
Apoptosis in rheumatoid arthritis: friend or foe.Rheum Dis Clin North Am. 2004 Aug;30(3):603-25, x. doi: 10.1016/j.rdc.2004.04.010. Rheum Dis Clin North Am. 2004. PMID: 15261344 Review.
-
Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3.Arthritis Rheum. 2003 Nov;48(11):3096-101. doi: 10.1002/art.11302. Arthritis Rheum. 2003. PMID: 14613271
-
The SCID mouse model: novel therapeutic targets - lessons from gene transfer.Springer Semin Immunopathol. 2003 Aug;25(1):65-78. doi: 10.1007/s00281-003-0126-2. Springer Semin Immunopathol. 2003. PMID: 12904892 Review.
-
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis.Arthritis Rheum. 2002 Jun;46(6):1512-8. doi: 10.1002/art.10309. Arthritis Rheum. 2002. PMID: 12115181
Cited by
-
Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1.Cell Commun Signal. 2024 May 15;22(1):271. doi: 10.1186/s12964-024-01571-4. Cell Commun Signal. 2024. PMID: 38750493 Free PMC article.
-
Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation.Int J Mol Sci. 2024 Mar 12;25(6):3228. doi: 10.3390/ijms25063228. Int J Mol Sci. 2024. PMID: 38542202 Free PMC article. Review.
-
m6A-mediated lncRNA MAPKAPK5-AS1 induces apoptosis and suppresses inflammation via regulating miR-146a-3p/SIRT1/NF-κB axis in rheumatoid arthritis.Cell Cycle. 2023 Dec-Dec;22(23-24):2602-2621. doi: 10.1080/15384101.2024.2302281. Epub 2024 Jan 16. Cell Cycle. 2023. PMID: 38225924
-
Oridonin Promotes Apoptosis in Rheumatoid Arthritis Fibroblast-like Synoviocytes Through PERK/eIF2α/CHOP of Endoplasmic Reticulum Stress Pathway.DNA Cell Biol. 2023 Dec;42(12):711-719. doi: 10.1089/dna.2023.0244. Epub 2023 Oct 20. DNA Cell Biol. 2023. PMID: 37862122
-
The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review.Int J Mol Sci. 2023 Sep 19;24(18):14293. doi: 10.3390/ijms241814293. Int J Mol Sci. 2023. PMID: 37762594 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical