Nutrient intakes and adenocarcinoma of the esophagus and distal stomach
- PMID: 12235648
- DOI: 10.1207/S15327914NC421_5
Nutrient intakes and adenocarcinoma of the esophagus and distal stomach
Abstract
We studied the relationship between nutrient intakes and adenocarcinoma of the esophagus and distal stomach among 124 esophageal adenocarcinoma cases, 124 distal stomach cancer cases, and 449 controls in a population-based case-control study in eastern Nebraska. The residual method was used to adjust nutrient intake quartiles or tertiles for energy intake. We observed significant inverse associations with risk of esophageal adenocarcinoma for dietary intakes of total vitamin A [highest vs. lowest quartile, multivariate odds ratio (OR) = 0.5, P for trend = 0.05], beta-cryptoxanthin (OR = 0.5, P = 0.05), riboflavin (OR = 0.5, P = 0.01), folate (OR = 0.5, P = 0.03), zinc (OR = 0.5, P = 0.05), dietary fiber (OR = 0.5, P = 0.05), protein (OR = 0.5, P = 0.02), and carbohydrate (OR = 0.4, P = 0.02). For distal stomach cancer, only vitamin C (OR = 0.6, P = 0.04), dietary fiber (OR = 0.4, P = 0.007), and carbohydrate (OR = 0.4, P = 0.004) were inversely associated with risk. Our analyses showed significant interaction between dietary fat intake, but not intakes of other nutrients, and respondent type for both cancer sites. Subgroup analyses among self-respondents revealed positive associations between saturated fat intake and risk of esophageal adenocarcinoma (OR = 1.0, 4.1, and 4.6 for intake tertiles, P for trend = 0.02) and risk of distal stomach cancer (OR = 1.0, 1.2, and 3.6, P = 0.03). However, no such associations were found among proxy respondents. Our data suggest that greater intake of dietary fiber, certain carotenoids, and vitamins may decrease the risk of esophageal adenocarcinoma, whereas greater intake of saturated fat may increase the risk of esophageal adenocarcinoma and distal stomach cancer.
Similar articles
-
Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma.Cancer Causes Control. 2009 Apr;20(3):279-88. doi: 10.1007/s10552-008-9242-6. Epub 2008 Oct 7. Cancer Causes Control. 2009. PMID: 18839322
-
Fiber intake and risk of adenocarcinomas of the esophagus and stomach.Cancer Causes Control. 2007 Sep;18(7):713-22. doi: 10.1007/s10552-007-9014-8. Epub 2007 Jun 12. Cancer Causes Control. 2007. PMID: 17562192
-
Nutrient intake and risk of subtypes of esophageal and gastric cancer.Cancer Epidemiol Biomarkers Prev. 2001 Oct;10(10):1055-62. Cancer Epidemiol Biomarkers Prev. 2001. PMID: 11588131
-
Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up.Cancer. 2000 Feb 15;88(4):737-48. Cancer. 2000. PMID: 10679641
-
Adenocarcinomas of the esophagus and gastric cardia: the role of diet.Nutr Cancer. 1997;27(3):298-309. doi: 10.1080/01635589709514541. Nutr Cancer. 1997. PMID: 9101561
Cited by
-
Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.Signal Transduct Target Ther. 2024 Jan 3;9(1):6. doi: 10.1038/s41392-023-01679-y. Signal Transduct Target Ther. 2024. PMID: 38169461 Free PMC article. Review.
-
Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis.BMC Cancer. 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. BMC Cancer. 2023. PMID: 37612616 Free PMC article.
-
Macronutrients Intake and Risk of Stomach Cancer: Findings from Case-Control Study.Nutrients. 2022 Jun 8;14(12):2373. doi: 10.3390/nu14122373. Nutrients. 2022. PMID: 35745103 Free PMC article.
-
Lifestyle, WCRF/AICR Recommendations, and Esophageal Adenocarcinoma Risk: A Systematic Review of the Literature.Nutrients. 2021 Oct 8;13(10):3525. doi: 10.3390/nu13103525. Nutrients. 2021. PMID: 34684526 Free PMC article.
-
Dietary carbohydrate intake and the risk of esophageal cancer: a meta-analysis.Biosci Rep. 2020 Feb 28;40(2):BSR20192576. doi: 10.1042/BSR20192576. Biosci Rep. 2020. PMID: 32027364 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical