Rapid emergence does not explain agitation following sevoflurane anaesthesia in infants and children: a comparison with propofol
- PMID: 12535042
- DOI: 10.1046/j.1460-9592.2003.00948.x
Rapid emergence does not explain agitation following sevoflurane anaesthesia in infants and children: a comparison with propofol
Abstract
Background: Emergence agitation in children is frequently associated with the use of the new highly insoluble volatile anaesthetics. Rapid emergence has been cited as one of the possible causes. Propofol also permits rapid emergence from general anaesthesia but is not associated with agitation.
Methods: The emergence characteristics of children receiving sevoflurane and propofol anaesthesia were examined. After induction with sevoflurane, 53 children, aged 2-36 months, who were undergoing ambulatory surgery, were randomized to receive maintenance anaesthesia with either sevoflurane or propofol. Introperative analgesia with either 2 micro g x kg-1 of intravenous fentanyl or a caudal block with 0.25% bupivacaine was supplied according to surgical procedure. An observer blinded to anaesthetic technique recorded the time to achieve extubation and recovery and assessed emergence behaviour. Data were analysed using Wilcoxon scores, Kruskal-Wallis test, chi-square and multiple regression analysis.
Results: The results showed that the time to extubation and recovery were similar between the two study groups, but that emergence agitation was significantly higher in the sevoflurane group compared with the propofol group. No relationship between analgesic technique and agitation scores was found.
Conclusions: Although both sevoflurane and propofol allow for rapid emergence from general anaesthesia, only sevoflurane is associated with a high incidence of emergence agitation in infants and young children. Rapid emergence does not fully explain this phenomena.
Similar articles
-
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.Cochrane Database Syst Rev. 2014 Sep 12;2014(9):CD007084. doi: 10.1002/14651858.CD007084.pub2. Cochrane Database Syst Rev. 2014. PMID: 25212274 Free PMC article. Review.
-
[Predisposing factors and prevention of emergence agitation].Masui. 2011 Apr;60(4):425-35. Masui. 2011. PMID: 21520589 Review. Japanese.
-
The effect of sub-Tenon lidocaine injection on emergence agitation after general anaesthesia in paediatric strabismus surgery.Eur J Anaesthesiol. 2011 May;28(5):334-9. doi: 10.1097/EJA.0b013e3283426ed6. Eur J Anaesthesiol. 2011. PMID: 21206277 Clinical Trial.
-
Effects of fentanyl on the incidence of emergence agitation in children receiving desflurane or sevoflurane anaesthesia.Eur J Anaesthesiol. 2004 Jul;21(7):538-42. doi: 10.1017/s0265021504007069. Eur J Anaesthesiol. 2004. PMID: 15318465 Clinical Trial.
-
Emergence agitation after sevoflurane versus propofol in pediatric patients.Anesth Analg. 2000 Sep;91(3):563-6. doi: 10.1097/00000539-200009000-00012. Anesth Analg. 2000. PMID: 10960377 Clinical Trial.
Cited by
-
Remimazolam-Based Anesthesia in Patients with Heart Failure Due to Mitral Regurgitation and Low Left Ventricular Function: A Case Series.Medicina (Kaunas). 2023 Dec 8;59(12):2136. doi: 10.3390/medicina59122136. Medicina (Kaunas). 2023. PMID: 38138239 Free PMC article.
-
Prevalence and risk factors of emergence agitation among pediatric patients undergo ophthalmic and ENT Surgery: a cross-sectional study.BMC Pediatr. 2023 Nov 24;23(1):598. doi: 10.1186/s12887-023-04434-y. BMC Pediatr. 2023. PMID: 37996779 Free PMC article.
-
The Topics and Publication Trends in Emergence Deliri-Um: A Bibliometric Analysis from 2002 to 2022.J Pain Res. 2023 Aug 7;16:2729-2745. doi: 10.2147/JPR.S419677. eCollection 2023. J Pain Res. 2023. PMID: 37577158 Free PMC article. Review.
-
Incidence of Emergence Delirium in the Pediatric PACU: Prospective Observational Trial.Children (Basel). 2022 Oct 21;9(10):1591. doi: 10.3390/children9101591. Children (Basel). 2022. PMID: 36291527 Free PMC article.
-
A systematic review and meta-analysis on the efficacy and safety of dexmedetomidine combined with sevoflurane anesthesia on emergence agitation in children.Transl Pediatr. 2022 Jul;11(7):1156-1170. doi: 10.21037/tp-22-172. Transl Pediatr. 2022. PMID: 35957999 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources